Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 Neutralization

entry_id	9sbb
deposition_date	2025-08-08
title	Monoclonal Antibodies from COVID-19 Convalescent Patients Target Cryptic Epitopes for Universal SARS-CoV-2 Neutralization
keywords	Immune complex, SARS-CoV-2, receptor binding domain, neutralizing antibody, VIRAL PROTEIN; VIRAL PROTEIN
method	X-RAY DIFFRACTION

rg_guinier	30.41 Å
rg_electron	30.12 Å
i0	74703000.00
molecular_weight	67767.0 kDa
excluded_volume	84535 ų
envelope_volume	108190 ų
shell_volume	31724 ų
envelope_diameter	107.8 Å
shell_rg	35.58 Å
envelope_rg	30.11 Å
shape_rg	30.10 Å
total_rg	30.68 Å
total_atoms	4777
n_residues	624
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	103.1 Å
rg_real	30.61 Å
rg_real_error	0.82 Å
i0_real	7.4700e+07
i0_real_error	1.2230e+06
rg_reciprocal	30.53 Å
i0_reciprocal	74700000.0000
total_estimate	0.8581
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	31.7 Å
skewness	0.521
kurtosis	-0.259
angular_range	— – 0.2600 Å−1
current_alpha	0.0000
highest_alpha	8665000.0000
n_real_points	53
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.794; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.886; Smooth: 0.885

Unit Cell

length_a	111.797 Å
length_b	87.975 Å
length_c	95.763 Å
angle_alpha	90.00 °
angle_beta	108.25 °
angle_gamma	90.00 °
z_pdb	4

Symmetry

space_group	C 1 2 1
int_tables_number	5
crystal_system	—

Refinement

resolution	2.120 Å
resolution_low	60.420 Å
r_factor	0.1988
r_work	0.1968
r_free	0.2302

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/sb/9sbb/pr_distribution.json
• pr_output /app/data/pr_computation/sb/9sbb/9sbb.pr.out
• pr_plot /app/data/visualization/pr_computation/sb/9sbb/9sbb_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/sb/9sbb/9sbb.dat
• saxs_fit /app/data/saxs_computation/sb/9sbb/9sbb.fit
• saxs_log /app/data/saxs_computation/sb/9sbb/9sbb.log
• saxs_plot /app/data/visualization/saxs_computation/sb/9sbb/9sbb_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/sb/9sbb/9sbb.fit
pddf	/app/data/pr_computation/sb/9sbb/9sbb.pr.out
profile	/app/data/saxs_computation/sb/9sbb/9sbb.dat