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11hw

;SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (Fab local refinement) ;

Method: ELECTRON MICROSCOPY D_max: 154.1 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	11hw
deposition_date	2026-02-25
title	;SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (Fab local refinement) ;
keywords	;S2prime, coronavirus, SARS-CoV-2, spike, fusion, entry, antiviral, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, SSGCID, VIRAL PROTEIN complex, C77G12, VIRAL PROTEIN ;; VIRAL PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	45.46 Å
rg_electron	45.27 Å
i0	359919000.00
molecular_weight	155610.0 kDa
excluded_volume	194250 Å³
envelope_volume	277660 Å³
shell_volume	53783 Å³
envelope_diameter	158.1 Å
shell_rg	45.71 Å
envelope_rg	46.12 Å
shape_rg	45.32 Å
total_rg	45.13 Å
total_atoms	11043
n_residues	1542
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	154.1 Å
rg_real	45.52 Å
rg_real_error	2.06 Å
i0_real	3.5990e+08
i0_real_error	7.2130e+06
rg_reciprocal	45.46 Å
i0_reciprocal	359900000.0000
total_estimate	0.6744
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	48.4 Å
skewness	0.271
kurtosis	-0.562
angular_range	— – 0.1750 Å⁻¹
current_alpha	0.0000
highest_alpha	26470000.0000
n_real_points	36
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.907; Stabil: 1.000; Sysdev: 0.062; Positv: 1.000; Valcen: 0.931; Smooth: 0.925

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	E-FICs-v3
formula_weight	67787.2 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	A,B,G
atom_count	11136

MTRLTVLALLAGLLASSRASMSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHRENDDDDKTGTGSQSNAESVQNHTFEVLNNTIRALELILRKLEILYEMILQLHEEVEAIQKAINVLYENQKLIANQFNSAIGKIQDSLSSTASALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLAKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQSAPHGVVFLHVTYVPAQEKNFTTAPAICHDGKAHFPREGVFVSNGTHWFVTQRNFYEPQIITTDNTFVSGNCDVVIGTNSVAYSNNSIAIPTNFTISVTTEILPVSMTKTSVDCTMYICGDSTECSNLLLQYGSFCTQLNRALTGIAVEQDKNTQEVFAQVKQIYKTPPIKDFGGFNFSQILPDPSKPSKRSFIEDLLFNKVTLADAGFTIDKEKWKEWRKEMENLTKEIKETLEEARKTLKQAEETFKTPSSGGTDDDDKTGSLNDIFEAQKIEWHEQGSHHHHHHHH

Source

organism	Severe acute respiratory syndrome coronavirus 2
ncbi_taxonomy_id	2697049
host_organism	Homo sapiens

Entity 2 polymer

description	Heavy chain Fab C77G12
formula_weight	24069.9 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	C,E,H

EVQLVESGGGVVQPGRSLRISCAVSGFTFGSYAMHWVRQAPGKGLEWVGVMSSDGHNEYYADSVKGRFTISRDNSRNKLYLEMNNLRVDDTAVFYCARGSDYVDDSPPLHYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	Light chain Fab C77G12
formula_weight	23175.7 kDa
src_method	man
entity_count	3

Polymer

type	polypeptide(L)
strand_id	D,F,I

DIQLTQSPSSLSASIGDRVTITCRASQDIANKLAWFQQAPGKAPKSLIYAASRLQSGVPSQFSGSGSGTDFTLTIESLQAGDFATYFCQQYDSFPFTFGPGTKVDVKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 non-polymer

description	2-acetamido-2-deoxy-beta-D-glucopyranose
formula_weight	221.2 kDa
src_method	syn
entity_count	6

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	93

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.80 Å
resolution_method	—
num_particles	225859

fit	/app/data/saxs_computation/1h/11hw/11hw.fit
pddf	/app/data/pr_computation/1h/11hw/11hw.pr.out
profile	/app/data/saxs_computation/1h/11hw/11hw.dat

;SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (Fab local refinement) ;

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 non-polymer

Entity 5 water

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)