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9t3q

Crystal structure of D1228V c-MET bound by cabozantinib.

Method: X-RAY DIFFRACTION Dmax: 67.2 Å Quality: GOOD

SAXS Profile

SAXS profile for 9t3q

P(r) Distribution

P(r) distribution for 9t3q
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1. Structure Basics

entry_id9t3q
deposition_date2025-10-28
titleCrystal structure of D1228V c-MET bound by cabozantinib.
keywordsKinase, c-met, drug discovery, cancer, NSCLC, TRANSFERASE; TRANSFERASE
methodX-RAY DIFFRACTION
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Download Data

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2. SAXS Parameters (CRYSOL)

rg_guinier20.24 Å
rg_electron19.46 Å
i032613500.00
molecular_weight30058.0 kDa
excluded_volume29446 ų
envelope_volume46949 ų
shell_volume20183 ų
envelope_diameter66.9 Å
shell_rg25.82 Å
envelope_rg19.80 Å
shape_rg19.45 Å
total_rg20.14 Å
total_atoms2283
n_residues289
n_harmonics20
q_range— – 0.5000 Å−1
n_points101
shell_typedirectional
solvent_density0.3340 e/ų
contrast_shell0.0300 e/ų
crysol_version4.1.3
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3. P(r) Analysis (GNOM)

dmax67.2 Å
rg_real20.19 Å
rg_real_error0.34 Å
i0_real3.2610e+07
i0_real_error3.8670e+05
rg_reciprocal20.20 Å
i0_reciprocal32610000.0000
total_estimate0.8837
solution_quality GOOD a GOOD solution
n_peaks2
r_peak_primary24.0 Å
skewness0.309
kurtosis-0.358
angular_range— – 0.3950 Å−1
current_alpha0.0000
highest_alpha8130000.0000
n_real_points71
gnom_version4.1.3
quality_criteria AN1: 0.000; Oscil: 0.829; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.999; Smooth: 0.997
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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

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6. Citations (1)

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7. Files & Curves (10)