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9uuj

Crystal structure of the mu2 subunit of the clathrin-adaptor protein 2 (AP2) bound to HPV16 E7(residues 22-39)

Method: X-RAY DIFFRACTION D_max: 87.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uuj
deposition_date	2025-05-07
last_revision	2025-09-10
title	Crystal structure of the mu2 subunit of the clathrin-adaptor protein 2 (AP2) bound to HPV16 E7(residues 22-39)
keywords	mu2, clathrin-adaptor protein 2, AP2, HPV16, E7, CR2, ENDOCYTOSIS; ENDOCYTOSIS
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	24.18 Å
rg_electron	23.59 Å
i0	13412100.00
molecular_weight	28333.0 kDa
excluded_volume	35861 Å³
envelope_volume	44679 Å³
shell_volume	17437 Å³
envelope_diameter	87.0 Å
shell_rg	28.40 Å
envelope_rg	24.01 Å
shape_rg	23.60 Å
total_rg	24.25 Å
total_atoms	1989
n_residues	254
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	87.1 Å
rg_real	24.52 Å
rg_real_error	0.83 Å
i0_real	1.3410e+07
i0_real_error	1.9180e+05
rg_reciprocal	24.44 Å
i0_reciprocal	13410000.0000
total_estimate	0.7685
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	20.4 Å
skewness	0.610
kurtosis	-0.229
angular_range	— – 0.3300 Å⁻¹
current_alpha	0.0000
highest_alpha	5390000.0000
n_real_points	65
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.555; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.402; Smooth: 0.920

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

Entity 1 polymer

description	AP-2 complex subunit mu
formula_weight	32124.7 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	1989

GHMQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRSGIYETRC

Source

organism	Rattus norvegicus
common_name	Norway rat
ncbi_taxonomy_id	10116
host_organism	Escherichia coli

Entity 2 polymer

description	Protein E7
formula_weight	2194.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

LYCYEQLNDSSEEEDEID

Source

organism	Human papillomavirus 16
ncbi_taxonomy_id	333760
host_organism	synthetic construct

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6. Citations (1)

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length_a	125.094 Å
length_b	125.094 Å
length_c	73.588 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	120.00 °
z_pdb	6

space_group	P 64
int_tables_number	172
crystal_system	—

resolution	3.703 Å
resolution_low	40.947 Å
r_factor	0.2098
r_work	0.2070
r_free	0.2336

fit	/app/data/saxs_computation/uu/9uuj/9uuj.fit
pddf	/app/data/pr_computation/uu/9uuj/9uuj.pr.out
profile	/app/data/saxs_computation/uu/9uuj/9uuj.dat

Crystal structure of the mu2 subunit of the clathrin-adaptor protein 2 (AP2) bound to HPV16 E7(residues 22-39)

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)