SAXSdb — 9uxv

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

Danio rerio

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count
2	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	GSDME_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 7–251； UniProt 1–245 Author chain B； PDBConstruct 7–251； UniProt 1–245

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

Danio rerio

UniProt Q6J2R6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count
2	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q6J2R6_DANRE
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 267–474； UniProt 265–472 Author chain B； PDBConstruct 267–474； UniProt 265–472

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

Danio rerio

UniProt Q9D8T2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count
2	Insufficient information	Monomer	Protein 1	No other associated polymer	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	GSDMD_MOUSE
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 252–256； UniProt 243–247 Author chain A； PDBConstruct 257–266； UniProt 274–283 Author chain B； PDBConstruct 252–256； UniProt 243–247 Author chain B； PDBConstruct 257–266； UniProt 274–283

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9uxv
Deposition date deposition_date	2025-05-14
Last revision last_revision	2026-05-27
Structure title title	Crystal structure of GSDME
Keywords keywords	Cell Death, GSDME, Pyroptosis, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9uxv__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9uxv__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9uxv__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	25.10 Å
Rg (electron density)	24.23 Å
Total Rg	25.04 Å
Atom count	3082
Residues	400
Excluded volume	55651 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9uxv__assembly_1__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`9uxv__assembly_2__model_1`	monomeric （1）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (1)

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Unit-cell length a length_a	78.450 Å
Unit-cell length b length_b	78.450 Å
Unit-cell length c length_c	353.800 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	16

Space group space_group	P 43 21 2
Space-group number int_tables_number	96
Crystal system crystal_system	tetragonal

Resolution resolution	2.950 Å
Low-resolution limit resolution_low	46.990 Å
R factor r_factor	0.2379
R_work r_work	0.2359
R_free r_free	0.2743

Description description	Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5
Molecular weight formula_weight	51882.4 kDa
Source method src_method	man
Copy count entity_count	2

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B
Atom count atom_count	5881

Crystal structure of GSDME

1. Protein Identity and Related Structures Protein Identity & Related Structures

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

9uxv__assembly_1__model_1

9uxv__assembly_1__model_1 | I(q)

9uxv__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)

Source organism organism	Danio rerio
Common name common_name	zebrafish
NCBI taxonomy ID ncbi_taxonomy_id	7955
Host organism host_organism	Escherichia coli

Crystal structure of GSDME

1. Protein Identity and Related Structures Protein Identity & Related Structures

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Gasdermin-E, N-terminal,Gasdermin-D, N-terminal,Gasdermin-D, p40,Deafness, autosomal dominant 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

9uxv__assembly_1__model_1

9uxv__assembly_1__model_1 | I(q)

9uxv__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (1)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

7. Citations (1)