9w2z

Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A

Method: ELECTRON MICROSCOPY

▼

1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytochrome c oxidase subunit 1

Bos taurus

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX1_BOVIN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–514； UniProt 1–514

Cytochrome c oxidase subunit 2

Bos taurus

UniProt P68553

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX2_BOSIN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain B； PDBConstruct 1–226； UniProt 2–227

Cytochrome c oxidase subunit 3

Bos taurus

UniProt P00415

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX3_BOVIN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain C； PDBConstruct 1–256； UniProt 4–259

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Bos taurus

UniProt P00423

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX41_BOVIN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain D； PDBConstruct 1–136； UniProt 33–168

Cytochrome c oxidase subunit 5A, mitochondrial

Bos taurus

UniProt P00426

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX5A_BOVIN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain E； PDBConstruct 1–102； UniProt 50–151

Cytochrome c oxidase subunit 5B, mitochondrial

Bos taurus

UniProt P00428

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX5B_BOVIN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain F； PDBConstruct 1–91； UniProt 34–124

Cytochrome c oxidase subunit 6A2, mitochondrial

Bos taurus

UniProt P07471

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CX6A2_BOVIN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain G； PDBConstruct 1–72； UniProt 24–95

Cytochrome c oxidase subunit 6B1

Bos taurus

UniProt P00429

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CX6B1_BOVIN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain H； PDBConstruct 1–81； UniProt 6–86

Cytochrome c oxidase subunit 6C

Bos taurus

UniProt P04038

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX6C_BOVIN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain I； PDBConstruct 1–70； UniProt 4–73

Cytochrome c oxidase subunit 7A1, mitochondrial

Bos taurus

UniProt P07470

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CX7A1_BOVIN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain J； PDBConstruct 1–55； UniProt 22–76

Cytochrome c oxidase subunit 7B, mitochondrial

Bos taurus

UniProt P13183

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX7B_BOVIN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain K； PDBConstruct 1–49； UniProt 30–78

Cytochrome c oxidase subunit 7C, mitochondrial

Bos taurus

UniProt P00430

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX7C_BOVIN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain L； PDBConstruct 1–44； UniProt 19–62

Cytochrome c oxidase subunit 8B, mitochondrial

Bos taurus

UniProt P10175

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit NDUFA4 × 1 （Q01321） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	COX8B_BOVIN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain M； PDBConstruct 1–40； UniProt 25–64

Cytochrome c oxidase subunit NDUFA4

Bos taurus

UniProt Q01321

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 14	Cytochrome c oxidase subunit 1 × 1 （P00396） Cytochrome c oxidase subunit 2 × 1 （P68553） Cytochrome c oxidase subunit 3 × 1 （P00415） Cytochrome c oxidase subunit 4 isoform 1, mitochondrial × 1 （P00423） Cytochrome c oxidase subunit 5A, mitochondrial × 1 （P00426） Cytochrome c oxidase subunit 5B, mitochondrial × 1 （P00428） Cytochrome c oxidase subunit 6A2, mitochondrial × 1 （P07471） Cytochrome c oxidase subunit 6B1 × 1 （P00429） Cytochrome c oxidase subunit 6C × 1 （P04038） Cytochrome c oxidase subunit 7A1, mitochondrial × 1 （P07470） Cytochrome c oxidase subunit 7B, mitochondrial × 1 （P13183） Cytochrome c oxidase subunit 7C, mitochondrial × 1 （P00430） Cytochrome c oxidase subunit 8B, mitochondrial × 1 （P10175） HEME-A × 2 COPPER (II) ION × 1 MAGNESIUM ION × 1 PEROXIDE ION × 1 (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE × 2 DINUCLEAR COPPER ION × 1 SODIUM ION × 1 ZINC ION × 1 (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE × 1	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	NDUA4_BOVIN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain N； PDBConstruct 1–81； UniProt 2–82

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

▼

2. Structure Basics 2. Structure Basics

Entry ID entry_id	9w2z
Deposition date deposition_date	2025-07-28
Structure title title	Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A
Keywords keywords	respiratory chain complex, supercomplex, submitochondrial particles, MOTOR PROTEIN, OXIDOREDUCTASE; OXIDOREDUCTASE
Experimental Method method	ELECTRON MICROSCOPY

▼

3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9w2z__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9w2z__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9w2z__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	39.78 Å
Rg (electron density)	38.60 Å
Total Rg	39.07 Å
Atom count	14825
Residues	1816
Excluded volume	267980 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9w2z__assembly_1__model_1`	14-meric （14）	Success	4.1.3-1-20251215 (887e7ef)	View Download

▶

4. Crystallography and Experiment 4. Crystallography & Experiment

▶

5. Entities and Polymers Entities & Polymers (23)

Entity 1 Entity 1 polymer

Description description	Cytochrome c oxidase subunit 1
Molecular weight formula_weight	57093.9 kDa
EC 编号 ec_number	7.1.1.9
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A
Atom count atom_count	14825

MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSLLIRAELGQPGTLLGDDQIYNVVVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVMITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMMWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLNDTWAKIHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTISSMGSFISLTAVMLMVFIIWEAFASKREVLTVDLTTTNLEWLNGCPPPYHTFEEPTYVNLK

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 2 Entity 2 polymer

Description description	Cytochrome c oxidase subunit 2
Molecular weight formula_weight	25909.2 kDa
EC 编号 ec_number	7.1.1.9
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

AYPMQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLSFDSYMIPTSELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMSSRPGLYYGQCSEICGSNHSFMPIVLELVPLKYFEKWSASML

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 3 Entity 3 polymer

Description description	Cytochrome c oxidase subunit 3
Molecular weight formula_weight	29443.1 kDa
EC 编号 ec_number	7.1.1.9
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

QTHAYHMVNPSPWPLTGALSALLMTSGLTMWFHFNSMTLLMIGLTTNMLTMYQWWRDVIRESTFQGHHTPAVQKGLRYGMILFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGIHPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGDRKHMLQALFITITLGVYFTLLQASEYYEAPFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFFRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYVSIYWW

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 4 Entity 4 polymer

Description description	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Molecular weight formula_weight	16038.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

YALPSYVDRRDYPLPDVAHVKNLSASQKALKEKEKASWSSLSIDEKVELYRLKFKESFAEMNRSTNEWKTVVGAAMFFIGFTALLLIWEKHYVYGPIPHTFEEEWVAKQTKRMLDMKVAPIQGFSAKWDYDKNEWK

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 5 Entity 5 polymer

Description description	Cytochrome c oxidase subunit 5A, mitochondrial
Molecular weight formula_weight	11717.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

TDEEFDARWVTYFNKPDIDAWELRKGMNTLVGYDLVPEPKIIDAALRACRRLNDFASAVRILEVVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDK

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 6 Entity 6 polymer

Description description	Cytochrome c oxidase subunit 5B, mitochondrial
Molecular weight formula_weight	9937.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

GGGVPTDEEQATGLEREVMLAARKGQDPYNILAPKATSGTKEDPNLVPSITNKRIVGCICEEDNSTVIWFWLHKGEAQRCPSCGTHYKLVP

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 7 Entity 7 polymer

Description description	Cytochrome c oxidase subunit 6A2, mitochondrial
Molecular weight formula_weight	8368.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

GARTWRFLTFGLALPSVALCTLNSWLHSGHRERPAFIPYHHLRIRTKPFSWGDGNHTFFHNPRVNPLPTGYE

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 8 Entity 8 polymer

Description description	Cytochrome c oxidase subunit 6B1
Molecular weight formula_weight	9610.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

QAKIKNYQTAPFDSRFPNQNQTRNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRVYKSLCPISWVSTWDDRRAEGTFPGKI

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 9 Entity 9 polymer

Description description	Cytochrome c oxidase subunit 6C
Molecular weight formula_weight	8177.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

ALAKPQMRGLLARRLRFHIVGAFMVSLGFATFYKFAVAEKRKKAYADFYRNYDSMKDFEEMRKAGIFQSA

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 10 Entity 10 polymer

Description description	Cytochrome c oxidase subunit 7A1, mitochondrial
Molecular weight formula_weight	6189.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

FENRVAEKQKLFQEDNGLPVHLKGGATDNILYRVTMTLCLGGTLYSLYCLGWASF

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 11 Entity 11 polymer

Description description	Cytochrome c oxidase subunit 7B, mitochondrial
Molecular weight formula_weight	5442.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

APDFHDKYGNAVLASGATFCVAVWVYMATQIGIEWNPSPVGRVTPKEWR

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 12 Entity 12 polymer

Description description	Cytochrome c oxidase subunit 7C, mitochondrial
Molecular weight formula_weight	5095.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

YEEGPGKNIPFSVENKWRLLAMMTLFFGSGFAAPFFIVRHQLLK

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 13 Entity 13 polymer

Description description	Cytochrome c oxidase subunit 8B, mitochondrial
Molecular weight formula_weight	4393.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

ITAKPAKTPTSPKEQAIGLSVTFLSFLLPAGWVLYHLDNY

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 14 Entity 14 polymer

Description description	Cytochrome c oxidase subunit NDUFA4
Molecular weight formula_weight	9205.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

LRQIIGQAKRHPSLIPLFIFIGAGGTGAALYVTRLALFNPDVSWDRKNNPEPWNKLGPNDQYKFYSVNVDYSKLKKEGPDF

Source Source

Source organism organism	Bos taurus
Common name common_name	domestic cattle
NCBI taxonomy ID ncbi_taxonomy_id	9913
Host organism host_organism	Bos taurus

Entity 15 Entity 15 non-polymer

Description description	HEME-A
Molecular weight formula_weight	852.8 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 16 Entity 16 non-polymer

Description description	COPPER (II) ION
Molecular weight formula_weight	63.5 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 17 Entity 17 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 18 Entity 18 non-polymer

Description description	PEROXIDE ION
Molecular weight formula_weight	32.0 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 19 Entity 19 non-polymer

Description description	(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE
Molecular weight formula_weight	749.0 kDa
Source method src_method	syn
Copy count entity_count	2

Entity 20 Entity 20 non-polymer

Description description	DINUCLEAR COPPER ION
Molecular weight formula_weight	127.1 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 21 Entity 21 non-polymer

Description description	SODIUM ION
Molecular weight formula_weight	23.0 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 22 Entity 22 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 23 Entity 23 non-polymer

Description description	(1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE
Molecular weight formula_weight	768.1 kDa
Source method src_method	syn
Copy count entity_count	1

▶

Resolution resolution	2.61 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	227858

Cryo-EM structure of complex IV on the bovine heart submitochondrial particles, IV-A

1. Protein Identity and Related Structures Protein Identity & Related Structures

Cytochrome c oxidase subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 5A, mitochondrial

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 5B, mitochondrial

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 6A2, mitochondrial

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 6B1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 6C

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cytochrome c oxidase subunit 7A1, mitochondrial

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer