Crystal structure of IL-33 and antibody Tozorakimab fab binary complex

entry_id	9wwh
deposition_date	2025-09-23
last_revision	2026-03-18
title	Crystal structure of IL-33 and antibody Tozorakimab fab binary complex
keywords	IL-33, Antibody, Tozorakimab, CYTOKINE/IMMUNE SYSTEM, CYTOKINE-IMMUNE SYSTEM complex; CYTOKINE/IMMUNE SYSTEM
method	X-RAY DIFFRACTION

rg_guinier	34.87 Å
rg_electron	34.45 Å
i0	232899000.00
molecular_weight	122210.0 kDa
excluded_volume	152790 ų
envelope_volume	201250 ų
shell_volume	49643 ų
envelope_diameter	129.4 Å
shell_rg	40.40 Å
envelope_rg	33.94 Å
shape_rg	34.43 Å
total_rg	34.97 Å
total_atoms	8601
n_residues	1128
n_harmonics	20
q_range	— – 0.5000 Å−1
n_points	101
shell_type	directional
solvent_density	0.3340 e/ų
contrast_shell	0.0300 e/ų
crysol_version	4.1.3

dmax	118.7 Å
rg_real	34.82 Å
rg_real_error	0.88 Å
i0_real	2.3290e+08
i0_real_error	3.5720e+06
rg_reciprocal	34.86 Å
i0_reciprocal	232900000.0000
total_estimate	0.8783
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	42.2 Å
skewness	0.318
kurtosis	-0.257
angular_range	— – 0.2250 Å−1
current_alpha	0.0000
highest_alpha	26160000.0000
n_real_points	46
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.810; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.985

Unit Cell

length_a	52.442 Å
length_b	162.561 Å
length_c	188.189 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

Symmetry

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

Refinement

resolution	3.510 Å
resolution_low	45.190 Å
r_factor	0.2311
r_work	0.2295
r_free	0.2593

Diffraction

temperature

100.0 K

Files (7)

• pr_distribution /app/data/pr_computation/ww/9wwh/pr_distribution.json
• pr_output /app/data/pr_computation/ww/9wwh/9wwh.pr.out
• pr_plot /app/data/visualization/pr_computation/ww/9wwh/9wwh_pr_distribution.png
• saxs_curve_dat /app/data/saxs_computation/ww/9wwh/9wwh.dat
• saxs_fit /app/data/saxs_computation/ww/9wwh/9wwh.fit
• saxs_log /app/data/saxs_computation/ww/9wwh/9wwh.log
• saxs_plot /app/data/visualization/saxs_computation/ww/9wwh/9wwh_saxs_profile.png

Curves (3)

fit	/app/data/saxs_computation/ww/9wwh/9wwh.fit
pddf	/app/data/pr_computation/ww/9wwh/9wwh.pr.out
profile	/app/data/saxs_computation/ww/9wwh/9wwh.dat