SAXSdb — 9x0j

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1. Structure Basics

entry_id	9x0j
deposition_date	2025-09-30
title	IL-33 and Etokimab fab and Tozorakimab fab ternary complex structure
keywords	IL33, antibody Etokimab fab, antibody Tozorakimab fab, CYTOKINE/IMMUNE SYSTEM, CYTOKINE-IMMUNE SYSTEM complex; CYTOKINE/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	45.45 Å
rg_electron	46.04 Å
i0	149003000.00
molecular_weight	91875.0 kDa
excluded_volume	111550 Å³
envelope_volume	181000 Å³
shell_volume	35932 Å³
envelope_diameter	165.2 Å
shell_rg	44.02 Å
envelope_rg	46.21 Å
shape_rg	45.99 Å
total_rg	46.09 Å
total_atoms	6496
n_residues	995
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	171.1 Å
rg_real	46.29 Å
rg_real_error	2.63 Å
i0_real	1.4900e+08
i0_real_error	2.8260e+06
rg_reciprocal	45.45 Å
i0_reciprocal	148900000.0000
total_estimate	0.6306
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	34.2 Å
skewness	0.596
kurtosis	-0.440
angular_range	— – 0.1750 Å⁻¹
current_alpha	0.0000
highest_alpha	9274000.0000
n_real_points	36
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.357; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.123; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Interleukin-33 (109-270)
formula_weight	17912.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	6499

ITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLSTENILFKLSET

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Tozorakimab-L Chain
formula_weight	22409.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

SYVLTQPPSVSVSPGQTASITCSGEGMGDKYAAWYQQKPGQSPVLVIYRDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCGVIQDNTGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	Tozorakimab-H Chain
formula_weight	24224.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	F

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGISAIDQSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQKFMQLWGGGLRYPFGYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 polymer

description	Etokimab-H Chain
formula_weight	24016.1 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	E

QVQLMQSGAEVKKPGASVKVSCKASGYTFTSYWMHWVRQAPGQGLEWMGTIYPRNSNTDYNQKFKARVTMTRDTSTSTVYMELSSLRSEDTAVYYCARPLYYYLTSPPTLFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVE

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 5 polymer

description	Etokimab-K Chain
formula_weight	23407.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

DIQLTQSPSFLSASVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTRHTGVPSRFSGSGSGTEFTLTISSLQPEDFATYYCQQAKTYPFTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	2.57 Å
resolution_method	—
num_particles	297408

fit	/app/data/saxs_computation/x0/9x0j/9x0j.fit
pddf	/app/data/pr_computation/x0/9x0j/9x0j.pr.out
profile	/app/data/saxs_computation/x0/9x0j/9x0j.dat

IL-33 and Etokimab fab and Tozorakimab fab ternary complex structure

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)