SAXSdb — 9x05

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1. Structure Basics

entry_id	9x05
deposition_date	2025-09-29
title	IL-33 and Itepekimab fab and Tozorakimab fab ternary complex structure
keywords	IL33, antibody Itepekimab fab, antibody Tozorakimab fab, CYTOKINE/IMMUNE SYSTEM, CYTOKINE-IMMUNE SYSTEM complex; CYTOKINE/IMMUNE SYSTEM
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	44.96 Å
rg_electron	45.60 Å
i0	165038000.00
molecular_weight	99008.0 kDa
excluded_volume	121170 Å³
envelope_volume	187460 Å³
shell_volume	36851 Å³
envelope_diameter	162.6 Å
shell_rg	44.82 Å
envelope_rg	45.77 Å
shape_rg	45.54 Å
total_rg	45.76 Å
total_atoms	6988
n_residues	1010
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	164.1 Å
rg_real	45.69 Å
rg_real_error	2.35 Å
i0_real	1.6500e+08
i0_real_error	3.7860e+06
rg_reciprocal	44.97 Å
i0_reciprocal	164900000.0000
total_estimate	0.7165
solution_quality	REASONABLE a REASONABLE solution
n_peaks	1
r_peak_primary	32.8 Å
skewness	0.562
kurtosis	-0.497
angular_range	— – 0.1750 Å⁻¹
current_alpha	0.0000
highest_alpha	10670000.0000
n_real_points	36
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.453; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.204; Smooth: 0.746

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	Itepekimab-H chain
formula_weight	23336.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B
atom_count	6991

EVQLVESGGNLEQPGGSLRLSCTASGFTFSRSAMNWVRRAPGKGLEWVSGISGSGGRTYYADSVKGRFTISRDNSKNTLYLQMNSLSAEDTAAYYCAKDSYTTSWYGGMDVWGHGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVE

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Tozorakimab-L chain
formula_weight	22409.8 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

SYVLTQPPSVSVSPGQTASITCSGEGMGDKYAAWYQQKPGQSPVLVIYRDTKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCGVIQDNTGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 3 polymer

description	Itepekimab-K chain
formula_weight	23282.9 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	E

DIQMTQSPSSVSASVGDRVTITCRASQGIFSWLAWYQQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFAIYYCQQANSVPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 4 polymer

description	Interleukin-33 (109-270)
formula_weight	17912.0 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A

ITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLSTENILFKLSET

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 5 polymer

description	Tozorakimab-H chain
formula_weight	24224.2 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	D

EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSGISAIDQSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQKFMQLWGGGLRYPFGYWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK

Source

organism	Homo sapiens
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.64 Å
resolution_method	—
num_particles	193399

fit	/app/data/saxs_computation/x0/9x05/9x05.fit
pddf	/app/data/pr_computation/x0/9x05/9x05.pr.out
profile	/app/data/saxs_computation/x0/9x05/9x05.dat

IL-33 and Itepekimab fab and Tozorakimab fab ternary complex structure

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Source

Entity 4 polymer

Polymer

Source

Entity 5 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)