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9zlg

Crystal structure of DCAF1 in complex with SDIPTAC C9

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

DDB1- and CUL4-associated factor 1

Homo sapiens

UniProt Q9Y4B6

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 8 (4P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide × 4 ;(4P,4'P)-5,5'-[(1E,36E)-3,35-dioxo-7,10,13,16,19,22,25,28,31-nonaoxa-4,34-diazaheptatriaconta-1,36-diene-1,37-diyl]bis{N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-1H-pyrrole-3-carboxamide} ; × 2 water × 8 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4pxw 4pxw 7ufv 7ufv 8f8e 8f8e 8og5 8og6 8og7 8og8 8og9 8oga

31 assemblies; showing the first 12

Homodimer
7sse 9ply 9y4q

3 assemblies

Homotetramer

None

Other homooligomers
9zl9 9zle 9zlg 9zli

4 assemblies

Heteromeric or nucleic-acid complex
3wa0 3wa0 4cc9 4p7i 4p7i 4z8l 4z8l 5aja 5jk7 5jk7 6n45 6zue

23 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DCAF1_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–314； UniProt 1077–1390 Author chain B； PDBConstruct 1–314； UniProt 1077–1390 Author chain C； PDBConstruct 1–314； UniProt 1077–1390 Author chain D； PDBConstruct 1–314； UniProt 1077–1390 Author chain E； PDBConstruct 1–314； UniProt 1077–1390 Author chain F； PDBConstruct 1–314； UniProt 1077–1390 Author chain G； PDBConstruct 1–314； UniProt 1077–1390 Author chain H； PDBConstruct 1–314； UniProt 1077–1390

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9zlg
Deposition date deposition_date2025-12-08
Structure title titleCrystal structure of DCAF1 in complex with SDIPTAC C9
Keywords keywordsSDIPTAC, PROTAC, HIV, E3 ligase, inhibitor, PROTEIN BINDING; PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9zlg__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9zlg__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9zlg__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）47.01 Å
Rg (electron density)46.38 Å
Total Rg46.65 Å
Atom count19231
Residues2359
Excluded volume334960 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9zlg__assembly_1__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)