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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O14641 New Search
15PDB entries
15Biological assembly
28chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2REY Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh) Deposited 2007-09-27 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 260–354（95 aa） Fragment：PDZ domain: Residues 261-355
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；293 K；0.2M Ammonium acetate, 0.1M Bis-tris pH 5.5, 25% PEG 3350, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 1.55 Å R-free 0.240
3CBX The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide Deposited 2008-02-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Chain B 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Mutation：C341S Mutation：C341S MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.8；292 K；60% 2-Methyl-2,4-pentanediol, 0.1 M sodium acetate, pH 4.8, VAPOR DIFFUSION, SITTING DROP, temperature 292K
Resolution 1.70 Å R-free 0.227
3CBY The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide Deposited 2008-02-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Chain B 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Mutation：C341S Mutation：C341S EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；1.6 M tri-sodium citrate, VAPOR DIFFUSION, SITTING DROP, temperature 292K
Resolution 1.50 Å R-free 0.182
3CBZ The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide Deposited 2008-02-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Mutation：C341S PO4 PHOSPHATE ION × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；292 K；0.1 M HEPES, 0.8 M sodium phosphate, 0.8 M Potassium phosphate, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 292K
Resolution 1.38 Å R-free 0.166
3CC0 The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide Deposited 2008-02-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Chain B 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Chain C 264–354（91 aa） Fragment：PDZ domain (UNP residues 264-354)
Mutation：C341S Mutation：C341S Mutation：C341S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；292 K；1.0 M Ammonium citrate tribasic, 0.1 M BIS-TRIS propane, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 292K
Resolution 1.75 Å R-free 0.238
4WIP DIX domain of human Dvl2 Deposited 2014-09-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 12–106（95 aa） Fragment：UNP residues 13-105
Chain B 12–106（95 aa） Fragment：UNP residues 13-105
Chain C 12–106（95 aa） Fragment：UNP residues 13-105
Mutation：Y27D Mutation：Y27D Mutation：Y27D 1PE PENTAETHYLENE GLYCOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；292 K；grew in PEG400 (cryo condition) over night
Resolution 2.69 Å R-free 0.248
5LNP Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from monomeric fraction Deposited 2016-08-05 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 416–510（95 aa） Fragment：DEP domain, UNP residues 416-510
Chain B 416–510（95 aa） Fragment：DEP domain, UNP residues 416-510
Chain C 416–510（95 aa） Fragment：DEP domain, UNP residues 416-510
Chain D 416–510（95 aa） Fragment：DEP domain, UNP residues 416-510
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1 M MES, pH=6.5 0.1 M NaCl 0.1 M Li2SO4 23 % PEG400
Resolution 1.99 Å R-free 0.246
5SUY Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from dimeric fraction Deposited 2016-08-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 416–510（95 aa） Fragment：UNP residues 416-510
Chain B 416–510（95 aa） Fragment：UNP residues 416-510
Chain C 416–510（95 aa） Fragment：UNP residues 416-510
Chain D 416–510（95 aa） Fragment：UNP residues 416-510
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1 M MES 0.1 M NaCl 0.1 M Li2SO4 22-26% PEG400
Resolution 1.88 Å R-free 0.217
5SUZ Domain-swapped dimer of human Dishevelled2 DEP domain: C-centered monoclinic crystal form crystallised from monomeric fraction Deposited 2016-08-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 416–509（94 aa） Fragment：UNP residues 416-509
Chain B 416–509（94 aa） Fragment：UNP residues 416-509
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；298 K；0.1 M MES, pH=6.5 0.2 M CaCl2 23% PEG350 MME
Resolution 1.84 Å R-free 0.263
6IW3 High resolution structure of Dvl2-DIX Y27W/C80S mutant Deposited 2018-12-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 12–93（82 aa） Fragment：DIX-domain
Mutation：Y27W, C80S No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；20% (w/v) PEG 6000, Tris-HCl pH 8.0, 200 mM lithium chloride
Resolution 1.64 Å R-free 0.229
6JCK Complex structure of Axin-DIX and Dvl2-DIX Deposited 2019-01-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 12–93（82 aa）
Mutation：V67A,K68A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；277 K；25% (w/v) PEG1500, 0.1 M Malonate-Imidazole-Borate buffer pH 7.0
Resolution 3.09 Å R-free 0.290
8WM9 Fzd4/DEP complex Deposited 2023-10-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 1–736（736 aa）
Not recorded Y01 CHOLESTEROL HEMISUCCINATE × 10 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.53 Å
8WMA Fzd4/DEP complex (local refined) Deposited 2023-10-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–736（736 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.47 Å
8WWR Crystal structure of apo human dishevelled 2 (Dvl2) PDZ domain Deposited 2023-10-26 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 261–354（94 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.1M Tri-sodium citrate, pH 5.6 20% (v/v) Isopropanol 20%(w/v) PEG4000
Resolution 1.75 Å R-free 0.253
8YR7 Crystal structure of human dishevelled 2 (Dvl2) PDZ domain fused with WGEF internal peptide motif Deposited 2024-03-20 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 261–353（93 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；293 K；0.1M Sodium acetate (pH 4.5), 3M Sodium chloride
Resolution 3.00 Å R-free 0.335

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.