← Back to search

Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：O15519 New Search
16PDB entries
16Biological assembly
66chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2N5R NMR structure of cFLIP-derived calmodulin binding peptide Deposited 2015-07-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 62–73（12 aa） Fragment：DED 1 domain residues 62-73
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；288 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR sample composition 20 mM potassium phosphate, 150 mM sodium chloride, 1 mM calcium chloride, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3H11 Zymogen caspase-8:c-FLIPL protease domain complex Deposited 2009-04-10 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 209–480（272 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 10.5；293 K；0.9 M sodium dihydrogen phosphate, 0.8 M dipotassium hydrogen phosphate, 0.1 M N-cyclohexyl-3-aminopropanesulfonic acid (CAPS), 0.2 M lithium sulfate, pH 10.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.90 Å R-free 0.250
3H13 c-FLIPL protease-like domain Deposited 2009-04-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 209–480（272 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；290 K；0.1 M Mes, 18% PEG, 5000 monomethyl ether, 0.1 M ammonium sulfate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 290K
Resolution 2.20 Å R-free 0.220
6M6O NMR SOLUTION STRUCTURE OF A C-FLIPs Deposited 2020-03-16 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–173（172 aa）
Mutation：F114G No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.5；298 K；Ionic strength (raw mmCIF value) 110；Pressure 1
NMR sample composition 0.6 nM [U-99% 13C; U-99% 15N] c-FLIPS, 1.0 nM EDTA-Na2, 1.0 nM TCEP, 0.02 % NaN3, 60 nM sodium phosphate, 50 mM sodium chloride, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
7DEE Structural Basis of the regulation of DISC Assembly by the interaction of c-FLIPs with Procaspase-8 Deposited 2020-11-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2–173（172 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 110；Pressure 1
NMR measurement conditions pH 7.4；298 K；Ionic strength (raw mmCIF value) 60；Pressure 1
NMR sample composition 10 mM C8-H1a, 0.002 % v/v sodium azide, 110 mM sodium phosphate, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 04 mM C8-H1a, 0.002 % v/v sodium azide, 110 mM sodium phosphate, 0.6 mM [U-99% 13C; U-99% 15N] c-FLIPs, 95% H2O/5% D2O | 95% H2O/5% D2O
NMR sample composition 0.002 % v/v sodium azide, 110 mM sodium phosphate, 0.6 mM [U-99% 13C; U-99% 15N] c-FLIPs, 1 mM TCEP, 1 mM EDTA, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
8YBX Structure of the FADD/Caspase-8/cFLIP death effector domain assembly Deposited 2024-02-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.68 Å
8YD7 Structure of FADD/Caspase-8/cFLIP death effector domain assembly Deposited 2024-02-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain K 1–181（181 aa）
Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) SE SELENIUM ATOM × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；HEPES, TBG, PEG8000, TCEP, sodium chloride
Resolution 3.32 Å R-free 0.231
8YD8 Structure of FADD/Caspase-8/cFLIP death effector domain assembly Deposited 2024-02-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Mutation：H7G Mutation：H7G Mutation：H7G Mutation：H7G No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；HEPES, PEG 8000, TBG, TCEP, sodium chloride
Resolution 3.11 Å R-free 0.241
8YM4 Structure of Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain F 1–181（181 aa）
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) SE SELENIUM ATOM × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M MES pH 6.5, 0.08 M sodium chloride, 0.2 M Potassium Thiocyanate, 10 % PEG 4000, 0.01 M TCEP
Resolution 2.34 Å R-free 0.253
8YM5 Structure of Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count
Chain F 1–181（181 aa）
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H7G Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M MES pH 6.5, 0.08 M sodium chloride, 0.2 M Potassium Thiocyanate, 10 % PEG 4000, 0.01 M TCEP
Resolution 2.09 Å R-free 0.231
8YM6 Structure of Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-08 Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric（13） Consistent with protein count
Chain F 1–181（181 aa）
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Chain M 1–181（181 aa）
Chain N 1–181（181 aa）
Chain O 1–181（181 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；0.1 M HEPES pH 7.5, 0.2 M Lithium chloride, 20 % PEG 400, 0.1 M TBG pH 9.0
Resolution 3.30 Å R-free 0.264
8YNI Structure of the FADD/Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: 11-meric（11） Consistent with protein count
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
8YNK Structure of the Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.62 Å
8YNL Structure of the Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count
Chain F 1–181（181 aa）
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.55 Å
8YNM Structure of the Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 11 PDB declaration: undecameric（11） Consistent with protein count
Chain F 1–181（181 aa）
Chain G 1–181（181 aa）
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Chain N 1–181（181 aa）
Chain O 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.49 Å
8YNN Structure of the Caspase-8/cFLIP death effector domain assembly Deposited 2024-03-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count
Chain H 1–181（181 aa）
Chain I 1–181（181 aa）
Chain J 1–181（181 aa）
Chain K 1–181（181 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.97 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.