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8ynl

Structure of the Caspase-8/cFLIP death effector domain assembly

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Caspase-8 subunit p10

Homo sapiens

UniProt Q14790

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 CASP8 and FADD-like apoptosis regulator subunit p43 × 6 （O15519） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2k7z 7lvm

2 assemblies

Homodimer
4zbw 5h31 5h31 5h33 6agw 6px9 6px9 6px9

8 assemblies

Homotetramer
3kjn 3kjq

2 assemblies

Other homooligomers
5l08

1 assemblies

Heteromeric or nucleic-acid complex
1f9e 1f9e 1f9e 1i4e 1i4e 1qdu 1qdu 1qdu 1qtn 2c2z 2fun 2fun

33 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CASP8_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–479； UniProt 1–479 Author chain B； PDBConstruct 1–479； UniProt 1–479 Author chain C； PDBConstruct 1–479； UniProt 1–479

CASP8 and FADD-like apoptosis regulator subunit p43

Homo sapiens

UniProt O15519

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 9 Caspase-8 subunit p10 × 3 （Q14790） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2n5r 6m6o

2 assemblies

Homodimer
3h13

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
3h11 7dee 8ybx 8yd7 8yd8 8ym4 8ym5 8ym6 8yni 8ynk 8ynl 8ynm

13 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name CFLAR_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain F； PDBConstruct 1–181； UniProt 1–181 Author chain G； PDBConstruct 1–181； UniProt 1–181 Author chain H； PDBConstruct 1–181； UniProt 1–181 Author chain I； PDBConstruct 1–181； UniProt 1–181 Author chain J； PDBConstruct 1–181； UniProt 1–181 Author chain K； PDBConstruct 1–181； UniProt 1–181

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8ynl
Deposition date deposition_date2024-03-11
Last revision last_revision2024-10-30
Structure title titleStructure of the Caspase-8/cFLIP death effector domain assembly
Keywords keywordsFADD, caspase-8, cellular FLICE-like inhibitory protein, Death effector domain, APOPTOSIS; APOPTOSIS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8ynl__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8ynl__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8ynl__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）40.39 Å
Rg (electron density)39.65 Å
Total Rg40.07 Å
Atom count12977
Residues1583
Excluded volume234730 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8ynl__assembly_1__model_1 nonameric （9） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (2)

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7. Citations (1)