当前蛋白身份:O75311 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
5CFB Crystal Structure of Human Glycine Receptor alpha-3 Bound to Strychnine 提交 2015-07-08 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 A 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
未记录 SY9 STRYCHNINE × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4;277 K;30-33% PEG-400, 200 mM magnesium chloride, 100 mM potassium chloride, 25 mM sodium citrate
分辨率 3.04 Å R-free 0.283
5TIN Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607 提交 2016-10-03 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 A 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 ZN ZINC ION × 5 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;200 mM Calcium Chloride, 22.5-27.5% PEG-350MME, 100 mM MES
分辨率 2.61 Å R-free 0.214
5TIO Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607 提交 2016-10-03 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 A 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 B 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 C 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 D 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 34–342(309 aa) 片段:UNP residues 34-460, with 343-418 deleted
链 E 419–460(42 aa) 片段:UNP residues 34-460, with 343-418 deleted
未记录 7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 ZN ZINC ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;200 mM Calcium Chloride, 22.5-27.5% PEG-350MME, 100 mM MES
分辨率 3.25 Å R-free 0.254
5VDH Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin 提交 2017-04-03 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 A 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 B 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 B 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 C 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 C 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 D 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 D 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 E 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 E 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
未记录 7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 IVM (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside × 5 ZN ZINC ION × 5 CL CHLORIDE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;200 mM calcium chloride, 22.5-27.5% PEG350 MME, 100 mM MES, pH 6.5
分辨率 2.85 Å R-free 0.236
5VDI Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607, Glycine, and Ivermectin 提交 2017-04-03 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 A 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 B 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 B 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 C 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 C 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 D 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 D 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 E 34–342(309 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
链 E 419–460(42 aa) 片段:UNP residues 34-342, ATG linker, UNP residues 419-460
突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 突变:N38Q 7C6 (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one × 5 GLY GLYCINE × 5 IVM (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside × 5 ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;200 mM calcium chloride, 22.5-27.5% PEG350 MME, 100 mM MES, pH 6.5
分辨率 3.10 Å R-free 0.256
9BOY Cryo-EM structure of human Glycine Receptor apha3-beta heteromer with glycine in nanodisc 提交 2024-05-06 Assembly 1 信息不足 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–464(431 aa)
链 B 34–464(431 aa)
链 C 34–464(431 aa)
链 D 34–464(431 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.81 Å
9BOZ Cryo-EM structure of human Glycine Receptor alpha3-beta heteromer in presence of glycine 提交 2024-05-06 Assembly 1 信息不足 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–464(431 aa)
链 B 34–464(431 aa)
链 C 34–464(431 aa)
链 D 34–464(431 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.84 Å
9BP0 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta with glycine 提交 2024-05-06 Assembly 1 信息不足 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–464(431 aa)
链 B 34–464(431 aa)
链 C 34–464(431 aa)
链 D 34–464(431 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 4 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.67 Å
9BP7 Cryo-EM structure of human heteromeric Glycine Receptor alpha3S346E-beta in presence of glycine and 2,6-DTBP 提交 2024-05-07 Assembly 1 信息不足 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 34–464(431 aa)
链 B 34–464(431 aa)
链 C 34–464(431 aa)
链 D 34–464(431 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 GLY GLYCINE × 3 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.60 Å
9BU2 Homomeric alpha3 glycine receptor in the presence of 1 mM glycine at pH 6.4 in a desensitized state 提交 2024-05-16 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 6.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.87 Å
9BU3 Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine in a desensitized state 提交 2024-05-16 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.80 Å
9BVH Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine in an apo state. 提交 2024-05-20 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 20 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 CLR CHOLESTEROL × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.58 Å
9BVJ Homomeric alpha3 glycine receptor in the presence of 1 mM glycine in an desensitized state. 提交 2024-05-20 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.80 Å
9BWB Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in a desensitized state 提交 2024-05-21 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 6.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.21 Å
9BWC Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an apo state 提交 2024-05-21 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 25 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 5 GLY GLYCINE × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 6.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.19 Å
9BWE Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine at pH 6.4 in an intermediate state 提交 2024-05-21 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 30 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 GLY GLYCINE × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 6.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.07 Å
9BWG Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in a desensitized state 提交 2024-05-21 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 ZN ZINC ION × 10 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.59 Å
9BWJ Homomeric alpha3 glycine receptor in the presence of 0.1 mM glycine and 0.1 mM zinc in an apo state 提交 2024-05-21 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 ZN ZINC ION × 10 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 35 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.21 Å
9BZP Homomeric alpha3 glycine receptor in the presence of 0.1 millimolar glycine and 1 micromolar zinc in a desensitized state 提交 2024-05-24 Assembly 1 其他组合 同源多聚体;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 A 1–464(464 aa)
链 B 1–464(464 aa)
链 C 1–464(464 aa)
链 D 1–464(464 aa)
链 E 1–464(464 aa)
未记录 GLY GLYCINE × 5 ZN ZINC ION × 5 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 25 PX4 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 20 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.88 Å