Current Protein Identity：P01031
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1CFA SOLUTION STRUCTURE OF A SEMI-SYNTHETIC C5A RECEPTOR ANTAGONIST AT PH 5.2, 303K, NMR, 20 STRUCTURES Deposited 1996-09-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
679–747（69 aa）
Fragment：RESIDUES 1 - 71
|
Mutation：Q71C | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5.2；303 K
|
Resolution not provided |
| 1KJS NMR SOLUTION STRUCTURE OF C5A AT PH 5.2, 303K, 20 STRUCTURES Deposited 1997-01-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
679–751（73 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 5.2；303 K
|
Resolution not provided |
| 1XWE NMR Structure of C345C (NTR) domain of C5 of complement Deposited 2004-10-30 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1530–1676（147 aa）
Fragment：C345C domain
|
Mutation：F1613A | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6；303 K；Ionic strength (raw mmCIF value) 20mM Na phospahte; 100mM NaCl；Pressure ambient
NMR sample composition
0.5-1.0mM C5-C345C; U-15N,13C; 20mM Na phosphate buffer; 100mM NaCl; 5uM EDTA; pH 6 | 95% H2O/5% D2O
|
Resolution not provided |
| 3CU7 Human Complement Component 5 Deposited 2008-04-16 | Assembly 1 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CD CADMIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；100mM NaCl, 1.5-3mM MES pH 5.5, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.10 Å R-free 0.281 |
| 3CU7 Human Complement Component 5 Deposited 2008-04-16 | Assembly 2 Other combination Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 CD CADMIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；100mM NaCl, 1.5-3mM MES pH 5.5, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.10 Å R-free 0.281 |
| 3CU7 Human Complement Component 5 Deposited 2008-04-16 | Assembly 3 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–1676（1676 aa）
Chain B
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 CD CADMIUM ION × 9 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.8；277 K；100mM NaCl, 1.5-3mM MES pH 5.5, pH 6.8, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 3.10 Å R-free 0.281 |
| 3HQA Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.59 Å R-free 0.253 |
| 3HQA Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.59 Å R-free 0.253 |
| 3HQA Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
679–750（72 aa）
Chain B
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.59 Å R-free 0.253 |
| 3HQB Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.30 Å R-free 0.307 |
| 3HQB Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.30 Å R-free 0.307 |
| 3HQB Crystal structure of human desarg-C5A Deposited 2009-06-05 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
679–750（72 aa）
Chain B
679–750（72 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.8；298 K；2.4 M sodium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.30 Å R-free 0.307 |
| 3KLS Structure of complement C5 in complex with SSL7 Deposited 2009-11-09 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | CD CADMIUM ION × 5 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.2；277 K；Reservoir contains 50mM MgAc2, 50 mM MES pH 6.2, mixed 1:1 with protein, VAPOR DIFFUSION, temperature 277K
|
Resolution 3.60 Å R-free 0.263 |
| 3KLS Structure of complement C5 in complex with SSL7 Deposited 2009-11-09 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–1676（1676 aa）
|
Not recorded | CD CADMIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.2；277 K；Reservoir contains 50mM MgAc2, 50 mM MES pH 6.2, mixed 1:1 with protein, VAPOR DIFFUSION, temperature 277K
|
Resolution 3.60 Å R-free 0.263 |
| 3KM9 Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 Deposited 2009-11-10 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | CD CADMIUM ION × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.2；277 K；Reservoir contains 50mM MgAc2, 50mM MES pH 6.2. Mixed 1:1 with concentrated protein, VAPOR DIFFUSION, temperature 277K
|
Resolution 4.20 Å R-free 0.297 |
| 3KM9 Structure of complement C5 in complex with the C-terminal beta-grasp domain of SSL7 Deposited 2009-11-10 | Assembly 2 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1–1676（1676 aa）
|
Not recorded | CD CADMIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6.2；277 K；Reservoir contains 50mM MgAc2, 50mM MES pH 6.2. Mixed 1:1 with concentrated protein, VAPOR DIFFUSION, temperature 277K
|
Resolution 4.20 Å R-free 0.297 |
| 3PRX Structure of Complement C5 in Complex with CVF and SSL7 Deposited 2010-11-30 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.4；292 K；3 M sodium malonate, pH 7.4, VAPOR DIFFUSION, temperature 292K
|
Resolution 4.30 Å R-free 0.261 |
| 3PRX Structure of Complement C5 in Complex with CVF and SSL7 Deposited 2010-11-30 | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 7.4；292 K；3 M sodium malonate, pH 7.4, VAPOR DIFFUSION, temperature 292K
|
Resolution 4.30 Å R-free 0.261 |
| 3PVM Structure of Complement C5 in Complex with CVF Deposited 2010-12-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 4.30 Å R-free 0.262 |
| 3PVM Structure of Complement C5 in Complex with CVF Deposited 2010-12-07 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
1–1676（1676 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 4.30 Å R-free 0.262 |
| 4A5W Crystal structure of C5b6 Deposited 2011-10-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
19–673（655 aa）
Chain A
752–1676（925 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 CA CALCIUM ION × 1 FUC alpha-L-fucopyranose × 1 MAN alpha-D-mannopyranose × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.8；167 MM HEPES-NAOH PH7.8
|
Resolution 3.50 Å R-free 0.270 |
| 4E0S Crystal Structure of C5b-6 Deposited 2012-03-05 | Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | NA SODIUM ION × 1 CA CALCIUM ION × 1 MAN alpha-D-mannopyranose × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 7.6；298 K；0.08M lithium chloride, 0.01M imidazole-HCl, pH 7.6, SMALL TUBES, temperature 298K
|
Resolution 4.21 Å R-free 0.278 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 5 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
678–747（70 aa）
Fragment：UNP residues 678-743
Chain B
678–747（70 aa）
Fragment：UNP residues 678-743
Chain C
678–747（70 aa）
Fragment：UNP residues 678-743
Chain D
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R Mutation：C704R Mutation：C704R Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
678–747（70 aa）
Fragment：UNP residues 678-743
Chain D
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4P39 Crystal structure of the human C5aR antagonist C5a-A8 Deposited 2014-03-06 | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
678–747（70 aa）
Fragment：UNP residues 678-743
Chain C
678–747（70 aa）
Fragment：UNP residues 678-743
|
Mutation：C704R Mutation：C704R | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；277 K；20% 2-propanol, 20% PEG 4000, 0.1 M Na citrate pH 5.6
|
Resolution 2.40 Å R-free 0.238 |
| 4UU9 Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody Deposited 2014-07-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
678–751（74 aa）
Fragment：C5A
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20% PEG10K, 8% ETHYLENE GLYCOL, 100MM HEPES PH 7.5
|
Resolution 2.12 Å R-free 0.202 |
| 4UU9 Crystal structure of the human c5a in complex with MEDI7814 a neutralising antibody Deposited 2014-07-25 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain D
678–751（74 aa）
Fragment：C5A
|
Not recorded | SO4 SULFATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
20% PEG10K, 8% ETHYLENE GLYCOL, 100MM HEPES PH 7.5
|
Resolution 2.12 Å R-free 0.202 |
| 5B4P Complex structure of human C5a and its binding repebody Deposited 2016-04-12 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
678–751（74 aa）
|
Not recorded | 1PE PENTAETHYLENE GLYCOL × 2 SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；Sodium acetate, PEG 400, ammonium sulfate
|
Resolution 2.40 Å R-free 0.310 |
| 5B4P Complex structure of human C5a and its binding repebody Deposited 2016-04-12 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
678–751（74 aa）
|
Not recorded | SO4 SULFATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；Sodium acetate, PEG 400, ammonium sulfate
|
Resolution 2.40 Å R-free 0.310 |
| 5B71 Crystal structure of complement C5 in complex with SKY59 Deposited 2016-06-03 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain E
20–124（105 aa）
Fragment：UNP RESIDUES 20-124
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M magnesium formate dehydrate, 15.0% w/v polyethylene glycol 3350, 20% v/v glycerol as cryoprotectant
|
Resolution 2.11 Å R-free 0.285 |
| 5B71 Crystal structure of complement C5 in complex with SKY59 Deposited 2016-06-03 | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain F
20–124（105 aa）
Fragment：UNP RESIDUES 20-124
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.2M magnesium formate dehydrate, 15.0% w/v polyethylene glycol 3350, 20% v/v glycerol as cryoprotectant
|
Resolution 2.11 Å R-free 0.285 |
| 5HCC Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3. Deposited 2016-01-04 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
679–1676（998 aa）
Fragment：UNP Residues 679-1676
Chain B
19–674（656 aa）
Fragment：UNP Residues 19-674
|
Not recorded | EDO 1,2-ETHANEDIOL × 7 CYS CYSTEINE × 1 DIO 1,4-DIETHYLENE DIOXIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；294 K；10% PEG 20K, 2% v/v 1,4 Dioxane, 0.1 M Bicine pH 9.0
|
Resolution 2.59 Å R-free 0.267 |
| 5HCD Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2 Deposited 2016-01-04 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
679–1676（998 aa）
Fragment：UNP Residues 679-1676
Chain B
19–674（656 aa）
Fragment：UNP Residues 19-674
|
Not recorded | CYS CYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；294 K；10% (w/v) PEG 20K, 2%(v/v)1,4 Dioxane, 0.1M Bicine pH 9.0
|
Resolution 2.98 Å R-free 0.282 |
| 5HCE Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus appendiculatus RaCI1 Deposited 2016-01-04 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
679–1676（998 aa）
Fragment：UNP Residues 679-1676
Chain B
19–674（656 aa）
Fragment：UNP Residues 19-674
|
Not recorded | CYS CYSTEINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 9；294 K；10% PEG 6K, 0.1 M Bicine pH 9.0
|
Resolution 3.12 Å R-free 0.281 |
| 5I5K Structure of complement C5 in complex with eculizumab Deposited 2016-02-15 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain B
1–1676（1676 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；0.1 M Imidazole pH 6.2
4% v/v Tacsimate pH 7
8% PEG 3350
|
Resolution 4.20 Å R-free 0.244 |
| 5I5K Structure of complement C5 in complex with eculizumab Deposited 2016-02-15 | Assembly 2 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277.15 K；0.1 M Imidazole pH 6.2
4% v/v Tacsimate pH 7
8% PEG 3350
|
Resolution 4.20 Å R-free 0.244 |
| 6H03 OPEN CONFORMATION OF THE MEMBRANE ATTACK COMPLEX Deposited 2018-07-06 | Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain A
19–673（655 aa）
Chain A
752–1676（925 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 37 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.60 Å |
| 6H04 Closed conformation of the Membrane Attack Complex Deposited 2018-07-06 | Assembly 1 Other combination Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count |
Chain A
19–673（655 aa）
Chain A
752–1676（925 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 38 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.60 Å |
| 6RPT Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of human complement C5 Deposited 2019-05-14 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
348–460（113 aa）
|
Not recorded | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；284.15 K；0.02 M Na2PO4/K2PO4, 20 % w/v PEG3350
|
Resolution 2.70 Å R-free 0.272 |
| 6RPT Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of human complement C5 Deposited 2019-05-14 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
348–460（113 aa）
|
Not recorded | GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；284.15 K；0.02 M Na2PO4/K2PO4, 20 % w/v PEG3350
|
Resolution 2.70 Å R-free 0.272 |
| 6RPT Structure of tick complement inhibitor CirpT1 complexed with macroglobubulin domain 4 of human complement C5 Deposited 2019-05-14 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
348–460（113 aa）
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；284.15 K；0.02 M Na2PO4/K2PO4, 20 % w/v PEG3350
|
Resolution 2.70 Å R-free 0.272 |
| 6RQJ Structure of human complement C5 complexed with tick inhibitors OmCI, RaCI1 and CirpT1 Deposited 2019-05-15 | Assembly 1 Other combination Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
678–1676（999 aa）
Chain B
19–673（655 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 7AD6 Crystal structure of human complement C5 in complex with the K92 bovine knob domain peptide. Deposited 2020-09-14 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1676（1676 aa）
Chain B
1–1676（1676 aa）
|
Not recorded | EDO 1,2-ETHANEDIOL × 3 CYS CYSTEINE × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1 M bicine/Trizma (pH 8.5), 10 % (w/v) PEG 8000, 20 % (v/v) ethylene glycol, 30 mM sodium fluoride, 30 mM sodium bromide and 30 mM sodium iodide.
|
Resolution 2.75 Å R-free 0.254 |
| 7AD7 Crystal structure of human complement C5 in complex with the K8 bovine knob domain peptide. Deposited 2020-09-14 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
1–1676（1676 aa）
Chain B
1–1676（1676 aa）
|
Not recorded | EOH ETHANOL × 4 MHA (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 2 CYS CYSTEINE × 1 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；296 K；0.1M ADA, 14% ethanol.
|
Resolution 2.30 Å R-free 0.234 |
| 7NYC cryoEM structure of 3C9-sMAC Deposited 2021-03-22 | Assembly 1 Other combination Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain A
19–1676（1658 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 7 CA CALCIUM ION × 3 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FUC alpha-L-fucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.54 Å |
| 7NYD cryoEM structure of 2C9-sMAC Deposited 2021-03-22 | Assembly 1 Other combination Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
19–1676（1658 aa）
|
Not recorded | MAN alpha-D-mannopyranose × 6 CA CALCIUM ION × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 FUC alpha-L-fucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.27 Å |
| 7OP0 Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. Deposited 2021-05-28 | Assembly 1 Other combination Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
678–1676（999 aa）
Chain B
19–675（657 aa）
Fragment：beta chain, UNP residues 1-675
|
Not recorded | EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1 M bicine/Trizma (pH 8.5), 10 % (w/v) PEG 8000, 20 % (v/v) ethylene glycol, 30 mM sodium fluoride, 30 mM sodium bromide, 30 mM sodium iodide.
|
Resolution 2.57 Å R-free 0.264 |
| 7Y64 Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein Deposited 2022-06-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain E
678–751（74 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8AYH Structure of Complement C5 in Complex with small molecule inhibitor and CVF Deposited 2022-09-02 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
678–1676（999 aa）
Chain C
19–675（657 aa）
Fragment：beta chain, UNP residues 1-675
|
Not recorded | H1H 5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5；50mM HEPES pH 7.5
100mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 8B0F CryoEM structure of C5b8-CD59 Deposited 2022-09-07 | Assembly 1 Other combination Heteromer；Protein × 7 PDB declaration: heptameric（7） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | CA CALCIUM ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8B0G 2C9, C5b9-CD59 structure Deposited 2022-09-07 | Assembly 1 Other combination Heteromer；Protein × 10 PDB declaration: decameric（10） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；20 mM HEPES pH 7.4, 120 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8B0H 2C9, C5b9-CD59 cryoEM structure Deposited 2022-09-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 9 PDB declaration: nonameric（9） Consistent with protein count |
Chain A
1–1676（1676 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；20 mM HEPES pH 7.4, 120 mM NaCl
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.30 Å |
| 8CML Cryo-EM structure of complement C5 in complex with nanobodies UNbC5-1 and UNbC5-2 Deposited 2023-02-20 | Assembly 1 Other combination Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
678–1676（999 aa）
Chain E
19–673（655 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4；1x PBS
cryo-EM vitrification conditions
Cryogen ETHANE；Blot 4 seconds at blot force 1
|
Resolution 3.60 Å |
| 8COE complement C5 in complex with the LCP0195 nanobody Deposited 2023-02-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
678–1676（999 aa）
Chain C
19–673（655 aa）
|
Not recorded | NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；292 K；0.025 M succinic acid pH 7.0 and 3.75% w/v polyethylene glycol 3350.
|
Resolution 4.20 Å R-free 0.269 |
| 8HK5 C5aR1-Gi-C5a protein complex Deposited 2022-11-24 | Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain B
678–751（74 aa）
|
Not recorded | PLM PALMITIC ACID × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.2
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.00 Å |
| 8HQC Structure of a GPCR-G protein in complex with a natural peptide agonist Deposited 2022-12-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain D
678–751（74 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.89 Å |
| 8IA2 Structure of C5a bound human C5aR1 in complex with Go (Composite map) Deposited 2023-02-07 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain D
678–751（74 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 8JZZ Structure of human C5a-desArg bound human C5aR1 in complex with Go Deposited 2023-07-06 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain D
678–751（74 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.31 Å |
| 9KX6 Structure of human C5a-desArg bound mouse C5aR1 in complex with Go Deposited 2024-12-06 | Assembly 1 Insufficient information Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain D
678–750（73 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 9Y6C X-ray structure analysis of human Complement Component 5 TE domain in complex with the peptide Ra30303 Deposited 2025-09-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
982–1305（324 aa）
|
Not recorded | GOL GLYCEROL × 1 8VH 1,3-dimethylbenzene × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；277 K；Proteros
|
Resolution 2.00 Å R-free 0.253 |