Current Protein Identity：P06241
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 10DJ Fyn Kinase Domain-Saracatinib Complex Structure Deposited 2026-01-13 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
263–537（275 aa）
|
Not recorded | H8H N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；4.0 M ammonium acetate, 0.1 M sodium acetate trihydrate, pH 4.6
|
Resolution 2.22 Å R-free 0.268 |
| 10DJ Fyn Kinase Domain-Saracatinib Complex Structure Deposited 2026-01-13 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
263–537（275 aa）
|
Not recorded | H8H N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；4.0 M ammonium acetate, 0.1 M sodium acetate trihydrate, pH 4.6
|
Resolution 2.22 Å R-free 0.268 |
| 1A0N NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES Deposited 1997-12-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
79–147（69 aa）
Fragment：SH3 DOMAIN, RESIDUES 82 - 148
|
Mutation：N-TERMINAL GS FROM EXPRESSION SYSTEM | No recorded non-water small molecule | SOLUTION NMR | mmCIF provides none of the parsed conditions | Resolution not provided |
| 1AOT NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, MINIMIZED AVERAGE STRUCTURE Deposited 1997-07-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
142–247（106 aa）
Fragment：SH2 DOMAIN
|
Mutation：C97S, C98S, C104S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6；293 K
|
Resolution not provided |
| 1AOU NMR STRUCTURE OF THE FYN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PEPTIDE, 22 STRUCTURES Deposited 1997-07-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
142–247（106 aa）
Fragment：SH2 DOMAIN
|
Mutation：C97S, C98S, C104S | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6；293 K
|
Resolution not provided |
| 1AVZ V-1 NEF PROTEIN IN COMPLEX WITH WILD TYPE FYN SH3 DOMAIN Deposited 1997-09-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
84–140（57 aa）
Fragment：SRC-HOMOLOGY 3 DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8.9；pH 8.9
|
Resolution 3.00 Å R-free 0.270 |
| 1AZG NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE Deposited 1997-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
81–147（67 aa）
Fragment：SH3 DOMAIN, RESIDUES 82 - 148
|
Mutation：N-TERMINAL GS FROM EXPRESSION SYSTEM | No recorded non-water small molecule | SOLUTION NMR | mmCIF provides none of the parsed conditions | Resolution not provided |
| 1EFN HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN Deposited 1996-06-29 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
85–142（58 aa）
Fragment：SH3 DOMAIN, RESIDUES 85-141
Chain C
85–142（58 aa）
Fragment：SH3 DOMAIN, RESIDUES 85-141
|
Mutation：R96I Mutation：R96I | PBM TRIMETHYL LEAD ION × 2 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.50 Å R-free 0.282 |
| 1FYN PHOSPHOTRANSFERASE Deposited 1995-05-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
80–141（62 aa）
Fragment：SH3 DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.30 Å |
| 1G83 CRYSTAL STRUCTURE OF FYN SH3-SH2 Deposited 2000-11-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
81–245（165 aa）
Fragment：SH3 AND SH2 DOMAIN
|
Mutation：C238S, C239S, C245S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；295 K；PEG 8000, sodium tartrate, TRIS
, pH 6.0, VAPOR DIFFUSION, temperature 295.0K
|
Resolution 2.60 Å R-free 0.277 |
| 1G83 CRYSTAL STRUCTURE OF FYN SH3-SH2 Deposited 2000-11-16 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
81–245（165 aa）
Fragment：SH3 AND SH2 DOMAIN
|
Mutation：C238S, C239S, C245S | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 6；295 K；PEG 8000, sodium tartrate, TRIS
, pH 6.0, VAPOR DIFFUSION, temperature 295.0K
|
Resolution 2.60 Å R-free 0.277 |
| 1M27 Crystal structure of SAP/FynSH3/SLAM ternary complex Deposited 2002-06-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain C
83–143（61 aa）
Fragment：SH3 domain (residues 82-143)
|
Not recorded | FLC CITRATE ANION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.6；297 K；Tartrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.50 Å R-free 0.266 |
| 1NYF NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE Deposited 1996-04-22 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
81–147（67 aa）
Fragment：SH3 DOMAIN, RESIDUES 82 - 148
|
Mutation：INS(GS-T82) | No recorded non-water small molecule | SOLUTION NMR | mmCIF provides none of the parsed conditions | Resolution not provided |
| 1NYG NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES Deposited 1996-04-22 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
81–147（67 aa）
Fragment：SH3 DOMAIN, RESIDUES 82 - 148
|
Mutation：INS(GS-T82) | No recorded non-water small molecule | SOLUTION NMR | mmCIF provides none of the parsed conditions | Resolution not provided |
| 1SHF CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN Deposited 1993-05-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
83–141（59 aa）
Chain B
83–141（59 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 1.90 Å |
| 1ZBJ Inferential Structure Determination of the Fyn SH3 domain using NOESY data from a 15N,H2 enriched protein Deposited 2005-04-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–141（59 aa）
Fragment：SH3 domain, Residues 83-141
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR | mmCIF provides none of the parsed conditions | Resolution not provided |
| 2DQ7 Crystal Structure of Fyn kinase domain complexed with staurosporine Deposited 2006-05-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain X
261–537（277 aa）
Fragment：Fyn, Protein kinase
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | STU STAUROSPORINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 8；277 K；1.15M ammonium sulfate, 0.2M NaCl, 0.1M imidazole, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.80 Å R-free 0.281 |
| 2MQI human Fyn SH2 free state Deposited 2014-06-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
148–248（101 aa）
Fragment：UNP residues 149-248
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 50；Pressure ambient
NMR sample composition
0.8-1.4 mM [U-13C; U-15N] FynSH2, 50 mM sodium phosphate, 5 mM DTT, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2MRJ Structure of Fyn protein SH2 bound Deposited 2014-07-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
148–248（101 aa）
Fragment：UNP residues 149-248
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
1 mM [U-99% 13C; U-99% 15N] FynSH2 bound, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 2MRK Fyn SH2 domain in complex with the natural inhibitory phosphotyrosine peptide Deposited 2014-07-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
149–248（100 aa）
Fragment：UNP residues 149-248
Chain B
528–537（10 aa）
Fragment：UNP residues 528-537
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.5；298 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
0.93 mM [U-99% 13C; U-99% 15N] protein_1, 1.2 mM protein_2, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 3H0F Crystal structure of the human Fyn SH3 R96W mutant Deposited 2009-04-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
73–142（70 aa）
Fragment：SH3 domain, UNP residues 73-142
|
Mutation：R96W | PG5 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 9.1；277 K；2.0M ammonium sulphate, 2% PEG 400, 0.1M Tris, pH 9.1, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.61 Å R-free 0.282 |
| 3H0H human Fyn SH3 domain R96I mutant, crystal form I Deposited 2009-04-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
73–142（70 aa）
Fragment：SH3 domain, UNP residues 73-142
|
Mutation：R96I | PG4 TETRAETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.5M ammonium sulphate, 0.1M sodium citrate, 1.0M lithium sulphate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 1.76 Å R-free 0.222 |
| 3H0I human Fyn SH3 domain R96I mutant, crystal form II Deposited 2009-04-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
73–142（70 aa）
Fragment：SH3 domain, UNP residues 73-142
|
Mutation：R96I | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.2M ammonium acetate, 0.1M TRIS, 30% v/v MPD, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.20 Å R-free 0.243 |
| 3H0I human Fyn SH3 domain R96I mutant, crystal form II Deposited 2009-04-09 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
73–142（70 aa）
Fragment：SH3 domain, UNP residues 73-142
|
Mutation：R96I | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5.6；291 K；0.2M ammonium acetate, 0.1M TRIS, 30% v/v MPD, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
|
Resolution 2.20 Å R-free 0.243 |
| 3UA6 Crystal Structure of the Human Fyn SH3 domain Deposited 2011-10-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | GOL GLYCEROL × 2 FMT FORMIC ACID × 5 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.246 |
| 3UA6 Crystal Structure of the Human Fyn SH3 domain Deposited 2011-10-21 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | FMT FORMIC ACID × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.246 |
| 3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | GOL GLYCEROL × 1 CL CHLORIDE ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.231 |
| 3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | ZN ZINC ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.231 |
| 3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.231 |
| 3UA7 Crystal Structure of the Human Fyn SH3 domain in complex with a peptide from the Hepatitis C virus NS5A-protein Deposited 2011-10-21 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | ZN ZINC ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；4 M sodium formate, 10 mM zinc chloride, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.50 Å R-free 0.231 |
| 4D8D Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Deposited 2012-01-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
84–141（58 aa）
Fragment：SRC-HOMOLOGY 3 DOMAIN (UNP Residues 84-141)
|
Mutation：R96W | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.3 M sodium potassium tartrate, 0.5 M bicine buffer , 1cmc D-octylglucopyranoside, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.52 Å R-free 0.238 |
| 4D8D Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant Deposited 2012-01-10 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
84–141（58 aa）
Fragment：SRC-HOMOLOGY 3 DOMAIN (UNP Residues 84-141)
|
Mutation：R96W | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.3 M sodium potassium tartrate, 0.5 M bicine buffer , 1cmc D-octylglucopyranoside, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.52 Å R-free 0.238 |
| 4EIK Crystal Structure of the Human Fyn SH3 domain in complex with the synthetic peptide VSL12 Deposited 2012-04-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
81–143（63 aa）
Fragment：SH3 domain (UNP residues 81-143)
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；5.5 M sodium formate, 0.1 M MES, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.60 Å R-free 0.195 |
| 4U17 Swapped dimer of the human Fyn-SH2 domain Deposited 2014-07-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric（2） Consistent with protein count |
Chain A
148–248（101 aa）
Fragment：Fyn-SH2 domain (UNP residues 148-248)
Chain C
148–248（101 aa）
Fragment：Fyn-SH2 domain (UNP residues 148-248)
|
Not recorded | PO4 PHOSPHATE ION × 5 EDO 1,2-ETHANEDIOL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；50 mM sodium phosphate pH 6.5
|
Resolution 1.99 Å R-free 0.255 |
| 4U17 Swapped dimer of the human Fyn-SH2 domain Deposited 2014-07-15 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: Dimeric（2） Consistent with protein count |
Chain B
148–248（101 aa）
Fragment：Fyn-SH2 domain (UNP residues 148-248)
|
Not recorded | PO4 PHOSPHATE ION × 4 EDO 1,2-ETHANEDIOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；50 mM sodium phosphate pH 6.5
|
Resolution 1.99 Å R-free 0.255 |
| 4U1P Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide Deposited 2014-07-16 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: DIMERIC（2） Consistent with protein count |
Chain A
148–248（101 aa）
Fragment：Human Fyn-SH2 domain, RESIDUES 148-248
|
Not recorded | 15P POLYETHYLENE GLYCOL (N=34) × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M MOPS/Na HEPES pH 7.5, 0.12 M monosaccharide mixture, PEG 1000, 12.5%(w/v) PEG 3350 and 12.5%(v/v) MPD
|
Resolution 1.40 Å R-free 0.188 |
| 4ZNX Crystal structure of the Fyn-SH3 domain in complex with the high affinity peptide APP12 Deposited 2015-05-05 | Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count |
Chain A
84–141（58 aa）
Fragment：SH3 DOMAIN, UNP residues 84-141
Chain B
84–141（58 aa）
Fragment：SH3 DOMAIN, UNP residues 84-141
Chain C
84–141（58 aa）
Fragment：SH3 DOMAIN, UNP residues 84-141
Chain D
84–141（58 aa）
Fragment：SH3 DOMAIN, UNP residues 84-141
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4 M sodium formate, 0.1 M Hepes
|
Resolution 2.10 Å R-free 0.222 |
| 5ZAU Complex of the human FYN SH3 and monobody binder Deposited 2018-02-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–141（57 aa）
Fragment：UNP residues 85-141
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 8；298 K；Ionic strength (raw mmCIF value) 300；Pressure 1
NMR sample composition
1 mM [U-99% 13C; U-99% 15N] FYN SH3 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
1 mM [U-99% 13C; U-99% 15N] Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
1 mM [U-99% 15N; U-98% 2H] FYN SH3 domain, 1.5 mM Unlabeled Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.2 mM [U-99% 15N] FYN SH3 domain, 1 mM Unlabeled Monobody Binder, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
0.2 mM [U-99% 15N] Monobody Binder, 1 mM Unlabeled FYN SH3 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6IPY His-tagged Fyn SH3 domain R96I mutant Deposited 2018-11-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
82–144（63 aa）
Fragment：UNP residues 82-144
|
Mutation：R96I | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 3.5；295 K；0.1M Citric acid pH 3.5 and 25%(w/v) Polyethylene glycol 3,350
|
Resolution 1.34 Å R-free 0.201 |
| 6IPZ Fyn SH3 domain R96W mutant, crystallized with 18-crown-6 Deposited 2018-11-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain Z
82–144（63 aa）
Fragment：UNP residues 82-144
|
Mutation：R96W | O4B 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；295 K；0.08M Sodium acetate trihydrate pH 4.6, 1.6M Ammonium sulfate, 20%(v/v) Glycerol
|
Resolution 1.58 Å R-free 0.209 |
| 7A2J Crystal structure of the Fyn SH3 domain in space group C21 at pH 7.5 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.247 |
| 7A2J Crystal structure of the Fyn SH3 domain in space group C21 at pH 7.5 Deposited 2020-08-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
83–142（60 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.247 |
| 7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.236 |
| 7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
83–142（60 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.236 |
| 7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
83–142（60 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.236 |
| 7A2K Crystal structure of the Fyn SH3 domain in space group P1 at pH 7.5 Deposited 2020-08-18 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
83–142（60 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；4.5M sodium formate, 0.1M Hepes
|
Resolution 1.50 Å R-free 0.236 |
| 7A2L Crystal structure of the Fyn SH3 domain mutant E129Q in space group C21 at pH 4.0 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：E129Q | FMT FORMIC ACID × 2 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；3.5M sodium formate, 0.1M sodium acetate
|
Resolution 1.90 Å R-free 0.261 |
| 7A2L Crystal structure of the Fyn SH3 domain mutant E129Q in space group C21 at pH 4.0 Deposited 2020-08-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
83–142（60 aa）
|
Mutation：E129Q | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；3.5M sodium formate, 0.1M sodium acetate
|
Resolution 1.90 Å R-free 0.261 |
| 7A2M Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：A95S D99T | NA SODIUM ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.50 Å R-free 0.255 |
| 7A2M Crystal structure of the Fyn SH3 domain A95S-D99T mutant in C21 space group Deposited 2020-08-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
83–142（60 aa）
|
Mutation：A95S D99T | NA SODIUM ION × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.50 Å R-free 0.255 |
| 7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：A95S D99T | FMT FORMIC ACID × 1 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.40 Å R-free 0.203 |
| 7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
83–142（60 aa）
|
Mutation：A95S D99T | FMT FORMIC ACID × 2 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.40 Å R-free 0.203 |
| 7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
83–142（60 aa）
|
Mutation：A95S D99T | FMT FORMIC ACID × 3 NA SODIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.40 Å R-free 0.203 |
| 7A2N Crystal structure of the Fyn SH3 domain A95S-D99T mutant in space group P21 Deposited 2020-08-18 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
83–142（60 aa）
|
Mutation：A95S D99T | FMT FORMIC ACID × 3 NA SODIUM ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；4.5 M sodium formate, 0.1 sodium acetate
|
Resolution 1.40 Å R-free 0.203 |
| 7A2O Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.5 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：L112V S114N S115T E121L R123H | PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；5% PEG 300, 1.5 ammonium sulfate, 0.1M sodium acetate
|
Resolution 0.94 Å R-free 0.175 |
| 7A2P Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 with PEG Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–143（61 aa）
|
Mutation：L112V S114N S115T E121L R123H | PGE TRIETHYLENE GLYCOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；5% PEG 300, 2.0 ammonium sulfate, 0.1M sodium acetate
|
Resolution 0.90 Å R-free 0.150 |
| 7A2Q Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 3.0 with PEG Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–143（61 aa）
|
Mutation：L112V S114N S115T E121L R123H | PG4 TETRAETHYLENE GLYCOL × 1 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；5% PEG 300, 5 mM beta-cyclodextrin, 2.0 ammonium sulfate, 0.1M sodium citrate
|
Resolution 0.94 Å R-free 0.161 |
| 7A2R Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 6.0 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–143（61 aa）
|
Mutation：L112V S114N S115T E121L R123H | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1.5 ammonium sulfate, 0.1M MES
|
Resolution 1.05 Å R-free 0.173 |
| 7A2S Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 5.0 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–143（61 aa）
|
Mutation：L112V S114N S115T E121L R123H | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；2.0 ammonium sulfate, 0.1M sodium acetate
|
Resolution 1.02 Å R-free 0.175 |
| 7A2T Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant at pH 4.0 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–143（61 aa）
|
Mutation：L112V S114N S115T E121L R123H | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；1 ammonium sulfate, 0.1M sodium acetate
|
Resolution 1.22 Å R-free 0.203 |
| 7A2U Crystal structure of the Fyn SH3 domain L112V-S114N-S115T at pH 4.5 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：L112V S114N S115T | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；298 K；1.5 M ammonium sulfate, 0.1 sodium acetate
|
Resolution 1.70 Å R-free 0.200 |
| 7A2V Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E129Q at pH 4.0 Deposited 2020-08-18 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
83–142（60 aa）
|
Mutation：L112V S114N S115T E129Q | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；1.5 M ammonium sulfate, 0.1 sodium acetate
|
Resolution 1.81 Å R-free 0.220 |
| 7A2W Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 3.0 Deposited 2020-08-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
83–142（60 aa）
Fragment：SH3 domain
|
Mutation：L112V S114N S115T E121L R123H | CIT CITRIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 3；298 K；0.5 M ammonium sulfate, 0.1 sodium citrate
|
Resolution 0.99 Å R-free 0.151 |
| 7A2X Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 5.0 Deposited 2020-08-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
83–142（60 aa）
Fragment：SH3 domain
|
Mutation：L112V S114N S115T E121L R123H | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 5；298 K；0.5 M ammonium sulfate, 0.1 sodium acetate
|
Resolution 0.92 Å R-free 0.148 |
| 7A2Y Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 4.0 Deposited 2020-08-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
83–142（60 aa）
Fragment：SH3 domain
|
Mutation：L112V S114N S115T E121L R123H | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；298 K；0.5 M ammonium sulfate, 0.1 sodium acetate
|
Resolution 0.97 Å R-free 0.146 |
| 7A2Z Crystal structure of the Fyn SH3 domain L112V-S114N-S115T-E121L-R123H mutant in complex with VSL12 at pH 6.0 Deposited 2020-08-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
83–142（60 aa）
Fragment：SH3 domain
|
Mutation：L112V S114N S115T E121L R123H | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1 M ammonium sulfate, 0.1 sodium acetate
|
Resolution 1.14 Å R-free 0.195 |
| 8KDX Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current Deposited 2023-08-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
85–142（58 aa）
Fragment：FynSH3 domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293.15 K；1.2 M Sodium citrate tribasic dehydrated, 0.1 M Tris buffer pH8.5
|
Resolution 1.01 Å R-free 0.185 |
| 9GHK Crystal structure of Fyn SH3 domain/tau 214-220 peptide complex Deposited 2024-08-15 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
80–143（64 aa）
Chain B
80–143（64 aa）
|
Not recorded | NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M NaCl, 0.4 M NaH2PO4, 1.5 M K2HPO4, 0.1 M imidazole pH 7.5
|
Resolution 1.42 Å R-free 0.218 |
| 9PGZ X-ray crystal structure of SRD42 Deposited 2025-07-08 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
87–141（55 aa）
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；279 K；0.5 M Sodium chloride, 0.01 M Hexadecyltrimethylammonium bromide
|
Resolution 2.60 Å R-free 0.247 |