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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P0DP25 New Search
23PDB entries
23Biological assembly
81chain/assembly records
Main Difference Dimensions in This Set
Different construct Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
7BYL Cryo-EM structure of human KCNQ4 Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
7BYM Cryo-EM structure of human KCNQ4 with retigabine Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 FBX ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7BYN Cryo-EM structure of human KCNQ4 with linopirdine Deposited 2020-04-23 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 4 K POTASSIUM ION × 3 FCC 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indol-2-one × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.30 Å
7CR3 human KCNQ2-CaM in apo state Deposited 2020-08-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.60 Å
7CR4 human KCNQ2-CaM in complex with ztz240 Deposited 2020-08-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded GB9 N-(6-chloranylpyridin-3-yl)-4-fluoranyl-benzamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.90 Å
7CR7 human KCNQ2-CaM in complex with retigabine Deposited 2020-08-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded FBX ethyl N-[2-azanyl-4-[(4-fluorophenyl)methylamino]phenyl]carbamate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.70 Å
7VNP Structure of human KCNQ4-ML213 complex with PIP2 Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PT5 [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate × 8 K POTASSIUM ION × 4 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.79 Å
7VNQ Structure of human KCNQ4-ML213 complex in nanodisc Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.96 Å
7VNR Structure of human KCNQ4-ML213 complex in digitonin Deposited 2021-10-11 Assembly 1 Insufficient information Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 7YV (1S,2S,4R)-N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-2-carboxamid × 4 K POTASSIUM ION × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.80 Å
7XNI human KCNQ1-CaM in apo state Deposited 2022-04-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
7XNK human KCNQ1-CaM in complex with ML277 Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
7XNL human KCNQ1-CaM-ML277-PIP2 complex in state A Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain B 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
7XNN human KCNQ1-CaM-ML277-PIP2 complex in state B Deposited 2022-04-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain A 1–149（149 aa）
Chain D 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded K POTASSIUM ION × 4 I0S (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.50 Å
8BD2 Calcium-bound Calmodulin variant G113R Deposited 2022-10-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–149（148 aa）
Not recorded CA CALCIUM ION × 2 SOLUTION NMR
NMR measurement conditions pH 6.69；298.1 K；Ionic strength (raw mmCIF value) 127；Pressure 1
NMR sample composition 100 mM potassium chloride, 5 mM calcium chloride, 2 mM sodium azide, 20 mM HEPES, 0.1 mM 2,2,3,3-tetradeutero TSP-d4, 1 mM (Ser81-Lys148-U-15N,13C) Calmodulin G113R, 95% H2O/5% D2O | 95% H2O/5% D2O
Resolution not provided
8Z5M human phosphorylase kinase alpha/gamma/delta subcomplex - inactive state Deposited 2024-04-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.66 Å
8Z5P human phosphorylase kinase - inactive state Deposited 2024-04-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain D 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.41 Å
8Z5Q human phosphorylase kinase - inactive state Deposited 2024-04-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain D 1–149（149 aa）
Chain H 1–149（149 aa）
Chain L 1–149（149 aa）
Chain P 1–149（149 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 4.24 Å
8Z5R human phosphorylase kinase alpha/gamma/delta subcomplex - phosphorylation and Ca2+ bound state Deposited 2024-04-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 1–149（149 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.52 Å
8Z5T human phosphorylase kinase - phosphorylation and Ca2+ bound state Deposited 2024-04-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 16 PDB declaration: hexadecameric（16） Consistent with protein count
Chain D 1–149（149 aa）
Chain H 1–149（149 aa）
Chain L 1–149（149 aa）
Chain P 1–149（149 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 8 ELECTRON MICROSCOPY
cryo-EM buffer pH 6.8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.74 Å
9IXY Human KCNQ2-CaM-Ebio2 Complex in the Presence of PIP2 Deposited 2024-07-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain G 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded A1L3C ~{N}-[7-[bis(fluoranyl)methoxy]-1-prop-2-ynyl-indazol-3-yl]-3,3-dimethyl-butanamide × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9LIZ Human KCNQ5-CaM in complex with PIP2 Deposited 2025-01-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å
9LJ1 Human KCNQ5-CaM-PIP2-HN37 complex in a closed conformation. Deposited 2025-01-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 4 PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
9LJ5 Human KCNQ5-CaM-PIP2-HN37 complex in an open conformation. Deposited 2025-01-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 8 PDB declaration: octameric（8） Consistent with protein count
Chain C 1–149（149 aa）
Chain E 1–149（149 aa）
Chain F 1–149（149 aa）
Chain H 1–149（149 aa）
Not recorded PIO [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate × 8 9MF methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.90 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.