当前蛋白身份:P14921 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1GVJ ETS-1 DNA BINDING AND AUTOINHIBITORY DOMAINS 提交 2002-02-14 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 297–441(145 aa) 片段:RESIDUES 297-441
链 B 297–441(145 aa) 片段:RESIDUES 297-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 5.6;297 K;0.2 M AMMONIUM ACETATE, 30% W/V PEG 4000, 0.1 M SODIUM CITRATE PH 5.6, PROTEIN CONCENTRATION 15 MG/ML PLUS 10 MM DTT, TEMPERATURE 297 K, FOR CRYOPROTECTION 10% OF PEG 400 WAS ADDED.
分辨率 1.53 Å R-free 0.235
2NNY Crystal structure of the Ets1 dimer DNA complex. 提交 2006-10-24 Assembly 1 蛋白–DNA 同源多聚体;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 280–441(162 aa) 片段:residues 280-441
链 B 280–441(162 aa) 片段:residues 280-441
突变:C350S , C416S 突变:C350S , C416S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;0.2 M ammonium acetate 28% PEG 2000 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, SITTING DROP, temperature 100K, temperature 298K
分辨率 2.58 Å R-free 0.271
2STT SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, 25 STRUCTURES 提交 1996-08-05 Assembly 1 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 A 320–415(96 aa)
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 6.8;305 K
分辨率未提供
2STW SOLUTION NMR STRUCTURE OF THE HUMAN ETS1/DNA COMPLEX, RESTRAINED REGULARIZED MEAN STRUCTURE 提交 1996-08-05 Assembly 1 蛋白–DNA 单体;蛋白 × 1 PDB 声明:trimeric(3) 与全部聚合物一致
链 A 320–415(96 aa)
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 6.8;305 K
分辨率未提供
3MFK Ets1 complex with stromelysin-1 promoter DNA 提交 2010-04-02 Assembly 1 蛋白–DNA 同源多聚体;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 280–441(162 aa) 片段:UNP residues 280-441
链 B 280–441(162 aa) 片段:UNP residues 280-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;15 mM ammonium chloride, 15 mM magnesium chloride, 0.7 M NDSB-195, 40 mM MES buffer (pH 6.5) and 11.5% v/v 2-Propanol, VAPOR DIFFUSION, SITTING DROP, temperature 295 K
分辨率 3.00 Å R-free 0.289
3RI4 Ets1 cooperative binding to widely separated sites on promoter DNA 提交 2011-04-12 Assembly 1 蛋白–DNA 同源多聚体;蛋白 × 2 PDB 声明:hexameric(6) 与全部聚合物一致
链 A 64–225(162 aa) 片段:UNP residues 280-441
链 D 64–225(162 aa) 片段:UNP residues 280-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 sitting drop vapor diffusion and macroseeding;pH 8.5;295 K;200 mM ammonium chloride, 10 mM calcium chloride, 50 mM Tris-HCl buffer (pH 8.5), 18.5% v/v PEG MME 2000, 3% v/v glycerol, sitting drop vapor diffusion and macroseeding, temperature 295K
分辨率 3.00 Å R-free 0.284
3WTS Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;10% PEG 4000, 0.1M AMMONIUM ACETATE, 0.05M TRIS HCL, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.279
3WTS Crystal structure of the complex comprised of ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;10% PEG 4000, 0.1M AMMONIUM ACETATE, 0.05M TRIS HCL, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.279
3WTT Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.277
3WTT Crystal structure of the complex comprised of phosphorylated ETS1, RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.35 Å R-free 0.277
3WTU Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.282
3WTU Crystal structure of the complex comprised of ETS1 (V170A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.282
3WTV Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.284
3WTV Crystal structure of the complex comprised of ETS1(V170G), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;4% PEG 8000, 0.1M AMMONIUM ACETATE, 0.02M MAGNESIUM CHLORIDE, 0.05M HEPES, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.284
3WTW Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;12% ISOPROPANOL, 0.02M MAGNESIUM CHLORIDE, 0.05M MES, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.90 Å R-free 0.264
3WTW Crystal structure of the complex comprised of ETS1(K167A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;12% ISOPROPANOL, 0.02M MAGNESIUM CHLORIDE, 0.05M MES, pH 6.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.90 Å R-free 0.264
3WTX Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
突变:Y329A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE PH5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.80 Å R-free 0.271
3WTX Crystal structure of the complex comprised of ETS1(Y329A), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
突变:Y329A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;10% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE PH5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.80 Å R-free 0.271
3WTY Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 C 276–441(166 aa) 片段:UNP RESIDUES 276-441
突变:G333P 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;4% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.268
3WTY Crystal structure of the complex comprised of ETS1(G333P), RUNX1, CBFBETA, and the tcralpha gene enhancer DNA 提交 2014-04-21 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 3 PDB 声明:pentameric(5) 与全部聚合物一致
链 H 276–441(166 aa) 片段:UNP RESIDUES 276-441
突变:G333P 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.8;298 K;4% PEG 4000, 0.25M AMMONIUM ACETATE, 0.05M SODIUM ACETATE, pH 5.8, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.268
3WTZ Crystal structure of ETS-1 DNA binding and autoinhibitory domains (276-441) 提交 2014-04-21 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 276–441(166 aa) 片段:UNP RESIDUES 276-441
链 B 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.8;9% MPD, 6% PEG 6000, 0.1M HEPES, pH 7.8, VAPOR DIFFUSION, SITTING DROP
分辨率 2.61 Å R-free 0.252
3WU0 Crystal structure of phosphorylated ETS-1 DNA binding and autoinhibitory domains (276-441) 提交 2014-04-21 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 276–441(166 aa) 片段:UNP RESIDUES 276-441
链 B 276–441(166 aa) 片段:UNP RESIDUES 276-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;5% PEG 3000, 25% MPD, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP
分辨率 2.60 Å R-free 0.277
3WU1 Crystal structure of the ETS1-RUNX1-DNA ternary complex 提交 2014-04-21 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 333–441(109 aa) 片段:UNP RESIDUES 333-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 7.5;298 K;11% PEG MME 550, 0.1M KCL, 0.015M MGCL2, 0.05M TRIS, pH 7.5, VAPOR DIFFUSION, temperature 298K
分辨率 2.40 Å R-free 0.249
4L0Y Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 1) 提交 2013-06-01 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 296–441(146 aa) 片段:UNP residues 296-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.6;298 K;Plate-shaped crystals grown from 100 mM potassium chloride, 15 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 14% v/v PEG550 MME, 6% v/v glycerol, crystal size improved by macroseeding, VAPOR DIFFUSION, temperature 298K
分辨率 2.50 Å R-free 0.245
4L0Z Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 2) 提交 2013-06-01 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 296–441(146 aa) 片段:UNP residues 296-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;Square bipyramid-shaped crystals grown from 100 mM potassium chloride, 15 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 14% v/v PEG550 MME, 6% v/v glycerol, crystal size improved by macroseeding, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.70 Å R-free 0.272
4L18 Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) 提交 2013-06-02 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 296–441(146 aa) 片段:UNP residues 296-441
未记录 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;2.5% w/v PEG4000, 5 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 5% v/v glycerol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.30 Å R-free 0.280
4L18 Crystal structure of Runx1 and Ets1 bound to TCR alpha promoter (crystal form 3) 提交 2013-06-02 Assembly 2 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 F 296–441(146 aa) 片段:UNP residues 296-441
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;298 K;2.5% w/v PEG4000, 5 mM magnesium chloride hexahydrate, 25 mM MES, pH 5.6, 5% v/v glycerol, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.30 Å R-free 0.280
4LG0 Structure of a ternary FOXO1-ETS1 DNA complex 提交 2013-06-27 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 331–440(110 aa) 片段:DNA binding domain, UNP residues 331-440
未记录 CA CALCIUM ION × 1 PG4 TETRAETHYLENE GLYCOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;30% PEG 400, 0.05M 2-Amino-2-hydroxymethyl-propane-1,3-diol, 0.1M potassium chloride, 0.01M magnesium chloride, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.19 Å R-free 0.243
5ZMC Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2 提交 2018-04-02 Assembly 1 蛋白–DNA 异源复合物;蛋白 × 2 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 331–441(111 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;290 K;0.1 M HEPES pH 7.0 and 2.0 M Ammonium sulphate
分辨率 2.99 Å R-free 0.288