Current Protein Identity：P21333
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2AAV Solution NMR structure of Filamin A domain 17 Deposited 2005-07-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1862–1955（94 aa）
Fragment：Filamin A domain 17
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.7；293 K；Ionic strength (raw mmCIF value) 50mM；Pressure 1
NMR sample composition
GAMV(1863-1956FLNA), U-13C, U-15N, NMR sample 0.3mM; 50mM sodium phosphate, 10mM dithiothreitol; 95% H2O, 5% D2O | 95% H2O/5% D2O
|
Resolution not provided |
| 2BP3 Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex Deposited 2005-04-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1863–1956（94 aa）
Fragment：ROD DOMAIN, RESIDUES 1863-1956
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8.2；1.75M AMMONIUM PHOSPHATE, PH 8.2, AFTER MICROSEEDING: 1.25M AMMONIUM SULFATE PH 8.2
|
Resolution 2.32 Å R-free 0.256 |
| 2BP3 Crystal structure of Filamin A domain 17 and GPIb alpha cytoplasmic domain complex Deposited 2005-04-18 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
1863–1956（94 aa）
Fragment：ROD DOMAIN, RESIDUES 1863-1956
|
Not recorded | GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8.2；1.75M AMMONIUM PHOSPHATE, PH 8.2, AFTER MICROSEEDING: 1.25M AMMONIUM SULFATE PH 8.2
|
Resolution 2.32 Å R-free 0.256 |
| 2BRQ Crystal structure of the filamin A repeat 21 complexed with the integrin beta7 cytoplasmic tail peptide Deposited 2005-05-11 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
2236–2329（94 aa）
Fragment：ROD DOMAIN, RESIDUES 2236-2329
Chain B
2236–2329（94 aa）
Fragment：ROD DOMAIN, RESIDUES 2236-2329
|
Not recorded | GSH Glutathione × 2 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 5.5；1.26 M SODIUM CITRATE, 0.1 M CITRIC ACID PH 5.5
|
Resolution 2.10 Å R-free 0.243 |
| 2J3S Crystal structure of the human filamin A Ig domains 19 to 21 Deposited 2006-08-23 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2045–2329（285 aa）
Fragment：IMMUNOGLOBULIN-LIKE DOMAINS 19 TO 21, RESIDUES 2045-2329
|
Not recorded | BR BROMIDE ION × 1 DIO 1,4-DIETHYLENE DIOXIDE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.1；PROTEIN WAS CRYSTALLIZED FROM 1.6M AMMONIUM SULPHATE, 0.1M CITRIC ACID PH 6.1, 10% DIOXANE.
|
Resolution 2.50 Å R-free 0.297 |
| 2J3S Crystal structure of the human filamin A Ig domains 19 to 21 Deposited 2006-08-23 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2045–2329（285 aa）
Fragment：IMMUNOGLOBULIN-LIKE DOMAINS 19 TO 21, RESIDUES 2045-2329
|
Not recorded | BR BROMIDE ION × 1 DIO 1,4-DIETHYLENE DIOXIDE × 2 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 6.1；PROTEIN WAS CRYSTALLIZED FROM 1.6M AMMONIUM SULPHATE, 0.1M CITRIC ACID PH 6.1, 10% DIOXANE.
|
Resolution 2.50 Å R-free 0.297 |
| 2JF1 CRYSTAL STRUCTURE OF THE FILAMIN A REPEAT 21 COMPLEXED WITH THE INTEGRIN BETA2 CYTOPLASMIC TAIL PEPTIDE Deposited 2007-01-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
2236–2329（94 aa）
Fragment：IG 21, RESIDUES 2236-2329
|
Not recorded | GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 4.6；1.6-1.58 M AMMONIUM SULPHATE, 0.1 M NA-ACETATE PH 4.6
|
Resolution 2.20 Å R-free 0.278 |
| 2K3T Solution Structure of IG-Like Domain 23 from Human Filamin A Deposited 2008-05-16 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2427–2522（96 aa）
Fragment：Ig-like domain 23 of Filamin A (UNP residues 2427-2522)
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 150；Pressure ambient
NMR sample composition
1 mM [U-13C; U-15N] FLNA23, 20 mM Sodium phosphate, 150 mM Sodium chloride, 1 mM DTT, 2 mM Sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 2K7P Filamin A Ig-like domains 16-17 Deposited 2008-08-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1772–1956（185 aa）
Fragment：Filamin 16-17, UNP residues 1772-1956
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；303 K；Ionic strength (raw mmCIF value) 100；Pressure ambient
NMR sample composition
1mM [U-13C; U-15N] FLNa16-17, 50mM sodium phosphate, 100mM potassium chloride, 1mM DTT, 2mM sodium azide, 2mM EDTA, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 2K7Q Filamin A Ig-like domains 18-19 Deposited 2008-08-19 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1954–2141（188 aa）
Fragment：Filamin 18-19, UNP residues 1954-2141
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；303 K；Ionic strength (raw mmCIF value) 100；Pressure ambient
NMR sample composition
0.8mM [U-13C; U-15N] FLNa18-19, 50mM sodium phosphate, 100mM potassium chloride, 1mM DTT, 2mM sodium azide, 93% H2O/7% D2O | 93% H2O/7% D2O
|
Resolution not provided |
| 2MTP The structure of Filamin repeat 21 bound to integrin Deposited 2014-08-28 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
2236–2330（95 aa）
Fragment：UNP residues 2236-2330
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.4；298 K；Ionic strength (raw mmCIF value) 25；Pressure ambient
NMR sample composition
1 mM [U-100% 13C; U-100% 15N; U-80% 2H] protein, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2W0P Crystal structure of the filamin A repeat 21 complexed with the migfilin peptide Deposited 2008-08-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
2236–2329（94 aa）
Fragment：IG-21, RESIDUES 2236-2329
Chain B
2236–2329（94 aa）
Fragment：IG-21, RESIDUES 2236-2329
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
1.7M (NH4)2SO4, 5% 2-PROPANOL
|
Resolution 1.90 Å R-free 0.239 |
| 2WFN Filamin A actin binding domain Deposited 2009-04-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
1–278（278 aa）
Fragment：ACTIN BINDING DOMAIN, RESIDUES 1-278
Chain B
1–278（278 aa）
Fragment：ACTIN BINDING DOMAIN, RESIDUES 1-278
|
Not recorded | SO4 SULFATE ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
1.7 M LITHIUM SULFATE, 0.1 M HEPES PH 7.5
|
Resolution 3.20 Å R-free 0.243 |
| 3CNK Crystal Structure of the dimerization domain of human filamin A Deposited 2008-03-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2559–2647（89 aa）
Fragment：Filamin 24, repeat 24
Chain B
2559–2647（89 aa）
Fragment：Filamin 24, repeat 24
|
Not recorded | SO4 SULFATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
pH 8.2；293 K；0.1M Tris, 30% PEG 3350, 0.2M Lithium Sulfate, pH 8.2, VAPOR DIFFUSION, HANGING DROP, temperature 293K, pH 8.20
|
Resolution 1.65 Å R-free 0.219 |
| 3HOC Structure of the actin-binding domain of human filamin A mutant E254K Deposited 2009-06-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–269（268 aa）
Fragment：Actin-binding domain
|
Mutation：E254K | PO4 PHOSPHATE ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.8；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, 5mM DTT, pH 8.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.263 |
| 3HOC Structure of the actin-binding domain of human filamin A mutant E254K Deposited 2009-06-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–269（268 aa）
Fragment：Actin-binding domain
|
Mutation：E254K | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.8；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, 5mM DTT, pH 8.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.263 |
| 3HOC Structure of the actin-binding domain of human filamin A mutant E254K Deposited 2009-06-02 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2–269（268 aa）
Fragment：Actin-binding domain
Chain B
2–269（268 aa）
Fragment：Actin-binding domain
|
Mutation：E254K Mutation：E254K | PO4 PHOSPHATE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.8；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, 5mM DTT, pH 8.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.263 |
| 3HOP Structure of the actin-binding domain of human filamin A Deposited 2009-06-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–269（268 aa）
Fragment：Actin-binding domain
|
Not recorded | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.288 |
| 3HOP Structure of the actin-binding domain of human filamin A Deposited 2009-06-03 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–269（268 aa）
Fragment：Actin-binding domain
|
Not recorded | PO4 PHOSPHATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.30 Å R-free 0.288 |
| 3HOR Structure of the actin-binding domain of human filamin A (reduced) Deposited 2009-06-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2–269（268 aa）
Fragment：Actin-binding domain
|
Not recorded | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, 5mM DTT, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.70 Å R-free 0.294 |
| 3HOR Structure of the actin-binding domain of human filamin A (reduced) Deposited 2009-06-03 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2–269（268 aa）
Fragment：Actin-binding domain
|
Not recorded | PO4 PHOSPHATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；20% PEG 4000, 0.2M lithium sulfate, 0.1M Tris HCl, 5mM DTT, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.70 Å R-free 0.294 |
| 3ISW Crystal structure of filamin-A immunoglobulin-like repeat 21 bound to an N-terminal peptide of CFTR Deposited 2009-08-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count |
Chain A
2236–2329（94 aa）
Fragment：UNP residues 2236-2329
Chain B
2236–2329（94 aa）
Fragment：UNP residues 2236-2329
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1M Bis-Tris Propane pH 7.0, 60% Tacsimate, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.80 Å R-free 0.298 |
| 3RGH Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens Deposited 2011-04-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
1158–1252（95 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；0.2 M ammonium acetate, 25%(w/v) PEG 3350, 0.1 M Bis-tris, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.44 Å R-free 0.279 |
| 3RGH Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens Deposited 2011-04-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
1158–1252（95 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | ACT ACETATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；0.2 M ammonium acetate, 25%(w/v) PEG 3350, 0.1 M Bis-tris, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.44 Å R-free 0.279 |
| 4M9P Crystal structure of the human filamin A Ig-like domains 3-5 Deposited 2013-08-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
478–766（289 aa）
Fragment：domains 3-5 (UNP residues 478-766)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；0.1 M sodium malonate, 12% w/v PEG3350, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.72 Å R-free 0.243 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | SO4 SULFATE ION × 1 PR PRASEODYMIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain B
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | SO4 SULFATE ION × 1 PR PRASEODYMIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | SO4 SULFATE ION × 1 PR PRASEODYMIUM ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain F
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain D
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | PR PRASEODYMIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 4P3W Crystal structure of the human filamin A Ig-like domains 20-21 in complex with migfilin peptide Deposited 2014-03-10 | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
2152–2329（178 aa）
Fragment：Filamin repeats 20 and 21, residues 2152-2329
|
Not recorded | SO4 SULFATE ION × 1 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；295 K；0.1 M MES pH 6, 1.9 M (NH4)2SO4, 0.1 M (CH3CO2)3Pr
|
Resolution 2.00 Å R-free 0.226 |
| 5XR1 Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2 Deposited 2017-06-07 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2228–2321（94 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.2；298 K；Ionic strength (raw mmCIF value) 150；Pressure 1
NMR sample composition
300 uM [U-13C; U-15N] FLN IG21 domain, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 6D8C Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin Deposited 2018-04-26 | Assembly 1 Protein heterocomplex Heteromer；Protein × 13 PDB declaration: tridecameric（13） Consistent with protein count |
Chain A
1–278（278 aa）
Fragment：UNP residues 1-278
Chain B
1–278（278 aa）
Fragment：UNP residues 1-278
Chain C
1–278（278 aa）
Fragment：UNP residues 1-278
Chain D
1–278（278 aa）
Fragment：UNP residues 1-278
Chain E
1–278（278 aa）
Fragment：UNP residues 1-278
|
Mutation：E254K Mutation：E254K Mutation：E254K Mutation：E254K Mutation：E254K | ADP ADENOSINE-5'-DIPHOSPHATE × 5 MG MAGNESIUM ION × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.54 Å |
| 6EW1 Crystal structure of the Filamin A Ig-like domains 3-5 mutant P637Q Deposited 2017-11-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
478–766（289 aa）
|
Mutation：P637Q | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.05 M ammonium citrate, 18 % PEG 3350
|
Resolution 2.31 Å R-free 0.273 |
| 7SC4 filamin complex-1 Deposited 2021-09-27 | Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2236–2329（94 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；2 M Ammonium Sulfate, 5% 2-propanol
|
Resolution 1.85 Å R-free 0.261 |
| 7SC4 filamin complex-1 Deposited 2021-09-27 | Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2236–2329（94 aa）
|
Not recorded | SO4 SULFATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；289.15 K；2 M Ammonium Sulfate, 5% 2-propanol
|
Resolution 1.85 Å R-free 0.261 |
| 7SFT Filamin complex-2 Deposited 2021-10-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2236–2330（95 aa）
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.4；298 K；Ionic strength (raw mmCIF value) 61；Pressure 1
NMR sample composition
1 mM [U-100% 13C; U-100% 15N] filamin Ig21, 2 mM Integrin alpha-IIb light chain, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
1 mM [U-15N; U-2H] filamin Ig21, 2 mM Integrin alpha-IIb light chain, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition
2 mM Integrin alpha-IIb light chain, 0.05 mM GST-filamin-Ig21, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 9LWX Crystal structure of the Filamin A repeat 21 Deposited 2025-02-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain D
2236–2329（94 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Sodium acetate trihydrate, 0.1 M Sodium cacodylate trihydrate, pH 6.5, 30% w/ Polyethylene glycol (PEG) 8,000
|
Resolution 2.29 Å R-free 0.268 |
| 9LWX Crystal structure of the Filamin A repeat 21 Deposited 2025-02-17 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
2236–2329（94 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Sodium acetate trihydrate, 0.1 M Sodium cacodylate trihydrate, pH 6.5, 30% w/ Polyethylene glycol (PEG) 8,000
|
Resolution 2.29 Å R-free 0.268 |
| 9LWX Crystal structure of the Filamin A repeat 21 Deposited 2025-02-17 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
2236–2329（94 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Sodium acetate trihydrate, 0.1 M Sodium cacodylate trihydrate, pH 6.5, 30% w/ Polyethylene glycol (PEG) 8,000
|
Resolution 2.29 Å R-free 0.268 |
| 9LWX Crystal structure of the Filamin A repeat 21 Deposited 2025-02-17 | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
2236–2329（94 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Sodium acetate trihydrate, 0.1 M Sodium cacodylate trihydrate, pH 6.5, 30% w/ Polyethylene glycol (PEG) 8,000
|
Resolution 2.29 Å R-free 0.268 |
| 9LXG Filamin A repeat 21 in complex with LARP4 Ala269-Asn281 peptide Deposited 2025-02-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
2236–2330（95 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.0 M Lithium sulfate, 0.1 M Sodium citrate pH 5.6, 0.5 M Ammonium sulfate
|
Resolution 2.46 Å R-free 0.259 |