当前蛋白身份:P25942 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1CZZ STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 17-RESIDUE CD40 PEPTIDE 提交 1999-09-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 D 250–258(9 aa) 片段:TRAF2-BINDING REGION
链 E 250–258(9 aa) 片段:TRAF2-BINDING REGION
非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.6;293 K;PEG4K, MES, PH 5.6, VAPOR DIFFUSION, temperature 293K
分辨率 2.70 Å R-free 0.267
1D00 STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE 提交 1999-09-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 I 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;293 K;PEG4K, MES, Ph6.0, VAPOR DIFFUSION, temperature 20K
分辨率 2.00 Å R-free 0.254
1D00 STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE 提交 1999-09-07 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 K 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
链 L 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
链 M 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;293 K;PEG4K, MES, Ph6.0, VAPOR DIFFUSION, temperature 20K
分辨率 2.00 Å R-free 0.254
1D00 STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE 提交 1999-09-07 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 N 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
链 O 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
链 P 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;293 K;PEG4K, MES, Ph6.0, VAPOR DIFFUSION, temperature 20K
分辨率 2.00 Å R-free 0.254
1D00 STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE 提交 1999-09-07 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 J 250–254(5 aa) 片段:ACETYLATED 5-RESIDUE PEPTIDE
非标准单体:是(mmCIF未提供具体位点) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;293 K;PEG4K, MES, Ph6.0, VAPOR DIFFUSION, temperature 20K
分辨率 2.00 Å R-free 0.254
1FLL MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 提交 2000-08-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 X 246–266(21 aa) 片段:CD40 (246-266) PEPTIDE
突变:N246K, C258S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;METHANOL, SODIUM CHLORIDE, TRIS BUFFER, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 3.50 Å R-free 0.312
1FLL MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 提交 2000-08-14 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 Y 246–266(21 aa) 片段:CD40 (246-266) PEPTIDE
突变:N246K, C258S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;METHANOL, SODIUM CHLORIDE, TRIS BUFFER, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 3.50 Å R-free 0.312
1FLL MOLECULAR BASIS FOR CD40 SIGNALING MEDIATED BY TRAF3 提交 2000-08-14 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 Y 246–266(21 aa) 片段:CD40 (246-266) PEPTIDE
突变:N246K, C258S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;METHANOL, SODIUM CHLORIDE, TRIS BUFFER, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 3.50 Å R-free 0.312
1LB6 TRAF6-CD40 Complex 提交 2002-04-02 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 230–238(9 aa) 片段:residues 230-238
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;PEG8000, Tris, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 1.80 Å R-free 0.258
3QD6 Crystal structure of the CD40 and CD154 (CD40L) complex 提交 2011-01-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 R 21–190(170 aa) 片段:extracellular domain
链 S 21–190(170 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;295 K;12% PEG6000, 0.1M MOPS, 10% isopropanol, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
分辨率 3.50 Å R-free 0.298
3QD6 Crystal structure of the CD40 and CD154 (CD40L) complex 提交 2011-01-18 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 T 21–190(170 aa) 片段:extracellular domain
链 U 21–190(170 aa) 片段:extracellular domain
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;295 K;12% PEG6000, 0.1M MOPS, 10% isopropanol, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
分辨率 3.50 Å R-free 0.298
5DMI Structure of the extracellular domain of the CD40 in complex with CHI220 FAB 提交 2015-09-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 23–193(171 aa) 片段:Extracellular domain residues 23-193
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.6;293 K;80mM sodiym acetate, pH 4.6, 1.6 M ammonium sulfate, 20% (v/v) glycerol
分辨率 3.69 Å R-free 0.207
5DMJ Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB 提交 2015-09-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 23–193(171 aa)
突变:D153, D180 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;100mM Citric Acid, pH 3.5, 20% (w/v) PEG 4000, 200 mM potassium formate
分辨率 2.79 Å R-free 0.258
5DMJ Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB 提交 2015-09-08 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 23–193(171 aa)
突变:D153, D180 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;100mM Citric Acid, pH 3.5, 20% (w/v) PEG 4000, 200 mM potassium formate
分辨率 2.79 Å R-free 0.258
5DMJ Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB 提交 2015-09-08 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 F 23–193(171 aa)
突变:D153, D180 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;100mM Citric Acid, pH 3.5, 20% (w/v) PEG 4000, 200 mM potassium formate
分辨率 2.79 Å R-free 0.258
5IHL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB 提交 2016-02-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 23–193(171 aa) 片段:Extra Cellular Domain (UNP residues 23-193)
突变:Protein produced with Asn 153 & Asn 180, but deglycosylated with PNGase F, which leaves Asp at those positions SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;80mM Tris-HCl, pH 8.5, 1.6M Ammonium dihydrogen phosphate, 20% (v/v) Glycerol
分辨率 3.30 Å R-free 0.298
5IHL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB 提交 2016-02-29 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 23–193(171 aa) 片段:Extra Cellular Domain (UNP residues 23-193)
突变:Protein produced with Asn 153 & Asn 180, but deglycosylated with PNGase F, which leaves Asp at those positions 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;80mM Tris-HCl, pH 8.5, 1.6M Ammonium dihydrogen phosphate, 20% (v/v) Glycerol
分辨率 3.30 Å R-free 0.298
5IHL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB 提交 2016-02-29 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 F 23–193(171 aa) 片段:Extra Cellular Domain (UNP residues 23-193)
突变:Protein produced with Asn 153 & Asn 180, but deglycosylated with PNGase F, which leaves Asp at those positions SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;80mM Tris-HCl, pH 8.5, 1.6M Ammonium dihydrogen phosphate, 20% (v/v) Glycerol
分辨率 3.30 Å R-free 0.298
5IHL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB 提交 2016-02-29 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 H 23–193(171 aa) 片段:Extra Cellular Domain (UNP residues 23-193)
突变:Protein produced with Asn 153 & Asn 180, but deglycosylated with PNGase F, which leaves Asp at those positions 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 3.5;293 K;80mM Tris-HCl, pH 8.5, 1.6M Ammonium dihydrogen phosphate, 20% (v/v) Glycerol
分辨率 3.30 Å R-free 0.298
6FAX Complex of Human CD40 Ectodomain with Lob 7.4 Fab 提交 2017-12-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 R 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;NA
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;293 K;NA
分辨率 2.99 Å R-free 0.231
6PE8 Crystal structure of CD40/ABBV-323 FAB complex 提交 2019-06-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 U 21–193(173 aa)
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;2M ammonium sulfate, 0.1M phosphate-citrate pH 4.2
分辨率 2.84 Å R-free 0.265
6PE8 Crystal structure of CD40/ABBV-323 FAB complex 提交 2019-06-20 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 T 21–193(173 aa)
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;2M ammonium sulfate, 0.1M phosphate-citrate pH 4.2
分辨率 2.84 Å R-free 0.265
6PE9 Crystal Structure of CD40 complexed to FAB516 提交 2019-06-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 I 21–193(173 aa)
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;1.6M Ammonium Sulfate 2% w/v PEG1000, 100 mM HEPES Sodium Salt pH 7.5
分辨率 3.13 Å R-free 0.255
6PE9 Crystal Structure of CD40 complexed to FAB516 提交 2019-06-20 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 G 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;1.6M Ammonium Sulfate 2% w/v PEG1000, 100 mM HEPES Sodium Salt pH 7.5
分辨率 3.13 Å R-free 0.255
6PE9 Crystal Structure of CD40 complexed to FAB516 提交 2019-06-20 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 U 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;1.6M Ammonium Sulfate 2% w/v PEG1000, 100 mM HEPES Sodium Salt pH 7.5
分辨率 3.13 Å R-free 0.255
6PE9 Crystal Structure of CD40 complexed to FAB516 提交 2019-06-20 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 V 21–193(173 aa)
未记录 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;1.6M Ammonium Sulfate 2% w/v PEG1000, 100 mM HEPES Sodium Salt pH 7.5
分辨率 3.13 Å R-free 0.255
6PE9 Crystal Structure of CD40 complexed to FAB516 提交 2019-06-20 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 J 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;296.15 K;1.6M Ammonium Sulfate 2% w/v PEG1000, 100 mM HEPES Sodium Salt pH 7.5
分辨率 3.13 Å R-free 0.255
7P3I Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein 提交 2021-07-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 21–193(173 aa) 片段:>FRAGMENT<
未记录 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;277 K;29.9999 %w/v PEG 4K, 0.24 M LiSO4, 0.0999 M TRIS, 0.35 M NaBr
分辨率 2.29 Å R-free 0.253
7P3I Crystal structure of human CD40/TNFRSF5 in complex with the anti-CD40 DARPin protein 提交 2021-07-07 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 21–193(173 aa) 片段:>FRAGMENT<
未记录 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;277 K;29.9999 %w/v PEG 4K, 0.24 M LiSO4, 0.0999 M TRIS, 0.35 M NaBr
分辨率 2.29 Å R-free 0.253
8YX1 CD40 in complex with Bleselumab Fab 提交 2024-04-01 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 R 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium chloride 20% w/v Polyethylene glycol 3,350
分辨率 2.70 Å R-free 0.265
8YX1 CD40 in complex with Bleselumab Fab 提交 2024-04-01 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 21–193(173 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium chloride 20% w/v Polyethylene glycol 3,350
分辨率 2.70 Å R-free 0.265
8YX9 CD40 in complex with Dacetuzumab Fab 提交 2024-04-02 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 21–193(173 aa)
未记录 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium citrate tribasic pH 7.0 20% w/v Polyethylene glycol 3,350
分辨率 2.80 Å R-free 0.262
8YX9 CD40 in complex with Dacetuzumab Fab 提交 2024-04-02 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 J 21–193(173 aa)
未记录 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium citrate tribasic pH 7.0 20% w/v Polyethylene glycol 3,350
分辨率 2.80 Å R-free 0.262
8YX9 CD40 in complex with Dacetuzumab Fab 提交 2024-04-02 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 21–193(173 aa)
未记录 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium citrate tribasic pH 7.0 20% w/v Polyethylene glycol 3,350
分辨率 2.80 Å R-free 0.262
8YX9 CD40 in complex with Dacetuzumab Fab 提交 2024-04-02 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 K 21–193(173 aa)
未记录 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293.15 K;0.2 M Ammonium citrate tribasic pH 7.0 20% w/v Polyethylene glycol 3,350
分辨率 2.80 Å R-free 0.262