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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P42858 New Search
31PDB entries
39Biological assembly
68chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
2LD0 Solution structure of the N-terminal domain of huntingtin (htt17) in 50 % TFE Deposited 2011-05-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–17（17 aa） Fragment：N-terminal residues 1-17
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 7.2；293 K；Ionic strength (raw mmCIF value) 0.15；Pressure ambient
NMR sample composition 0.2 - 0.3 mM 15N labeled at PHE11 htt17, 10 % D2O, 50 % d3 TFE, 40 % PBS, trifluoroethanol/water | trifluoroethanol/water
Resolution not provided
2LD2 Solution structure of the N-terminal domain of huntingtin (htt17) in presence of DPC micelles Deposited 2011-05-13 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–17（17 aa） Fragment：N-terminal residues 1-17
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6；293 K；Ionic strength (raw mmCIF value) 0.025；Pressure ambient
NMR sample composition 0.2-0.3 mM 15N labeled at PHE11 htt17, 10 % D2O, 25 mM sodium phosphate, 100 mM d38 DPC, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
3IO4 Huntingtin amino-terminal region with 17 Gln residues - Crystal C90 Deposited 2009-08-13 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999
Not recorded ZN ZINC ION × 8 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；277 K；12% polyethylene glycol, 200 mM Zn Acetate, 200 mM Sodium Acetate, 100 mM Sodium Cacodylate pH 6.5 to 7.4, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 3.63 Å R-free 0.304
3IO6 Huntingtin amino-terminal region with 17 Gln residues - crystal C92-a Deposited 2009-08-13 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：FUSION PROTEIN, SEE REMARK 999
Chain B 1–64（64 aa） Fragment：FUSION PROTEIN, SEE REMARK 999
Chain C 1–64（64 aa） Fragment：FUSION PROTEIN, SEE REMARK 999
Not recorded ZN ZINC ION × 5 CA CALCIUM ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.2；pH 7.2, VAPOR DIFFUSION, HANGING DROP
Resolution 3.70 Å R-free 0.293
3IOR Huntingtin amino-terminal region with 17 Gln residues - crystal C95 Deposited 2009-08-14 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999
Not recorded ZN ZINC ION × 6 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；278 K；12% PEG 4000, 200 mM Zn acetate, 200 mM Sodium acetate, 100 mM Sodium Cacodylate pH 6.5-7.4 , VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.60 Å R-free 0.267
3IOT Huntingtin amino-terminal region with 17 Gln residues - crystal C92-b Deposited 2009-08-14 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Not recorded ZN ZINC ION × 9 CA CALCIUM ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；278 K；12% PEG 4000, 200 mM Zn acetate, 200 mM Sodium acetate, 100 mM Sodium Cacodylate pH 6.5-7.4, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.50 Å R-free 0.295
3IOU Huntingtin amino-terminal region with 17 Gln residues - crystal C94 Deposited 2009-08-14 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Not recorded ZN ZINC ION × 8 CA CALCIUM ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；278 K；12% PEG 4000, 200 mM Zn acetate, 200 mM Sodium acetate, 100 mM Sodium Cacodylate pH 6.5-7.4, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.70 Å R-free 0.299
3IOV Huntingtin amino-terminal region with 17 Gln residues - crystal C99 Deposited 2009-08-14 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Not recorded ZN ZINC ION × 6 CA CALCIUM ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；278 K；12% PEG 4000, 200 mM Zn acetate, 200 mM Sodium acetate, 100 mM Sodium Cacodylate pH 6.5-7.4, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.70 Å R-free 0.280
3IOW Huntingtin amino-terminal region with 17 Gln residues - crystal C99-Hg Deposited 2009-08-14 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain B 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Chain C 1–64（64 aa） Fragment：Fusion protein, see remark 999,Fusion protein, see remark 999
Not recorded ZN ZINC ION × 7 CA CALCIUM ION × 10 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；278 K；12% PEG 4000, 200 mM Zn acetate, 200 mM Sodium acetate, 100 mM Sodium Cacodylate pH 6.5-7.4, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.50 Å R-free 0.281
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain H 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain J 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain L 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain N 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
3LRH Structure of anti-huntingtin VL domain in complex with huntingtin peptide Deposited 2010-02-11 Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain P 5–18（14 aa） Fragment：huntingtin peptide
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.1；293 K；10 % PEG600, 0.1 mM potassium phosphate dibasic/citric acid, pH 4.1, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.60 Å R-free 0.278
4FE8 Crystal Structure of Htt36Q3H-EX1-X1-C1(Alpha) Deposited 2012-05-29 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Huntingtin protein exon1 domain (UNP residues 1-164),Huntingtin protein exon1 domain (UNP residues 1-164)
Chain B 1–64（64 aa） Fragment：Huntingtin protein exon1 domain (UNP residues 1-164),Huntingtin protein exon1 domain (UNP residues 1-164)
Chain C 1–64（64 aa） Fragment：Huntingtin protein exon1 domain (UNP residues 1-164),Huntingtin protein exon1 domain (UNP residues 1-164)
Mutation：HQHQH,HQHQH Mutation：HQHQH,HQHQH Mutation：HQHQH,HQHQH ZN ZINC ION × 31 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；PEG12K, Na Acetate, Zn Acetate, Na Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.00 Å R-free 0.275
4FEB Crystal Structure of Htt36Q3H-EX1-X1-C2(Beta) Deposited 2012-05-29 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa）
Chain B 1–64（64 aa）
Chain C 1–64（64 aa）
Mutation：HQHQH Mutation：HQHQH Mutation：HQHQH ZN ZINC ION × 38 NA SODIUM ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions hanging drop；pH 6.5；278 K；PEG12K, Na Acetate, Zn Acetate, Na Cacodylate, pH 6.5, hanging drop, temperature 278K
Resolution 2.80 Å R-free 0.275
4FEC Crystal Structure of Htt36Q3H Deposited 2012-05-30 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Huntingtin protein exon1 domain
Chain B 1–64（64 aa） Fragment：Huntingtin protein exon1 domain
Chain C 1–64（64 aa） Fragment：Huntingtin protein exon1 domain
Mutation：HQHQH,HQHQH Mutation：HQHQH,HQHQH Mutation：HQHQH,HQHQH ZN ZINC ION × 31 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；PEG12K, Na Acetate, Zn Acetate, Na Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 3.00 Å R-free 0.275
4FED Crystal Structure of Htt36Q3H Deposited 2012-05-30 Assembly 1 Insufficient information Homooligomer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 1–64（64 aa） Fragment：Huntingtin protein exon1 domain,Huntingtin protein exon1 domain
Chain B 1–64（64 aa） Fragment：Huntingtin protein exon1 domain,Huntingtin protein exon1 domain
Chain C 1–64（64 aa） Fragment：Huntingtin protein exon1 domain,Huntingtin protein exon1 domain
Mutation：HQHQH Mutation：HQHQH Mutation：HQHQH ZN ZINC ION × 35 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；PEG12K, Na Acetate, Zn Acetate, Na Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
Resolution 2.81 Å R-free 0.269
4RAV Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin Deposited 2014-09-11 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain E 1–17（17 aa）
Chain F 1–17（17 aa）
Not recorded SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；291 K；0.2 M ammonium sulphate, 25% PEG 4000 and 0.1 M sodium acetate buffer at pH 4.6, VAPOR DIFFUSION, SITTING DROP, temperature 291K
Resolution 2.50 Å R-free 0.226
6EZ8 Human Huntingtin-HAP40 complex structure Deposited 2017-11-14 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 4.00 Å
6N8C Structure of the Huntingtin tetramer/dimer mixture determined by paramagnetic NMR Deposited 2018-11-29 Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 2–24（23 aa）
Chain B 2–24（23 aa）
Chain C 2–24（23 aa）
Chain D 2–24（23 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；278 K；Ionic strength (raw mmCIF value) 50；Pressure 1
NMR measurement conditions pH 6.5；283 K；Ionic strength (raw mmCIF value) 50；Pressure 1
NMR sample composition 1 mM [U-13C; U-15N] httNT-Q7, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 1 mM 2-13C glucose; U-15N httNT-Q7, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.6 mM [U-15N] httNT-Q7, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.75 mM 2-13C glucose; U-15N httNT-Q7, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.4 mM 2-13C glucose; U-15N httNT-Q7, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
6RMH The Rigid-body refined model of the normal Huntingtin. Deposited 2019-05-06 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；blot 9 seconds incubate 30 seconds
Resolution 9.60 Å
6X9O High resolution cryoEM structure of huntingtin in complex with HAP40 Deposited 2020-06-03 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
6YEJ Cryo-EM structure of the Full-length disease type human Huntingtin Deposited 2020-03-24 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 18–3142（3125 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE；30 seconds incubation 8 seconds blotting
Resolution 18.20 Å
7DXJ Human 46QHuntingtin-HAP40 complex structure Deposited 2021-01-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–38（38 aa）
Chain A 39–3142（3104 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 3.60 Å
7DXK Human 128QHuntingtin-HAP40 complex structure Deposited 2021-01-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–38（38 aa）
Chain A 39–3142（3104 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7
cryo-EM vitrification conditions Cryogen ETHANE-PROPANE
Resolution 4.10 Å
8R2O Huntingtin-Q17, 1-66, N-MBP fusion Deposited 2023-11-07 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–64（64 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.25；293 K；0.8 M KH2PO4, 0.8 M NaH2PO4, and 0.1 M TRIS/HCl pH 8.25
Resolution 3.23 Å R-free 0.238
8R2O Huntingtin-Q17, 1-66, N-MBP fusion Deposited 2023-11-07 Assembly 2 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 1–64（64 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.25；293 K；0.8 M KH2PO4, 0.8 M NaH2PO4, and 0.1 M TRIS/HCl pH 8.25
Resolution 3.23 Å R-free 0.238
8SAH Huntingtin C-HEAT domain in complex with HAP40 Deposited 2023-03-31 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 2093–3136（1044 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8VLX HTT in complex with HAP40 and a small molecule. Deposited 2024-01-12 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded A1ACS N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；25 mM Hepes, 300 mM NaCl, 0.025%CHAPS, 1mM DTT, 1mM Ligand, 1% DMSO
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.60 Å
8W15 HTT in complex with HAP40 in the apo state. Deposited 2024-02-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；25 mM Hepes, 300 mM NaCl, 0.025%CHAPS, 1mM DTT, 1% DMSO
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.72 Å
8YAE Cryo-ET structure of huntingtin actin complex Deposited 2024-02-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 14 PDB declaration: tetradecameric（14） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 10.08 Å
8YAO Cryo-ET structure of huntingtin actin dimer complex Deposited 2024-02-09 Assembly 1 Protein heterocomplex Heteromer；Protein × 28 PDB declaration: 28-meric（28） Consistent with protein count
Chain A 1–3142（3142 aa）
Chain a 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 8
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 20.80 Å
9PMW Structure of HTTQ23-HAP40 complex bound to macrocycles HHL1, HD4 and HL2 Deposited 2025-07-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.10 Å
9PN0 Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2 Deposited 2025-07-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded No recorded non-water small molecule ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å
9YR6 Structure of HTTQ23-HAP40 complex bound to a small molecule ligand Deposited 2025-10-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–3142（3142 aa）
Not recorded A1CYY 2-[(1R)-2,2-difluorocyclopropyl]-N-[(1-methyl-1H-indazol-6-yl)methyl]aniline × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.30 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.