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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P43432 New Search
10PDB entries
12Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
6SFF mouse Interleukin-12 subunit beta - p80 homodimer in space group I41 Deposited 2019-08-01 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6.5；287 K；120 mM monosaccharides, 50 mM Imidazole, 50 mM MES, pH6.5, 20% Ethylene glycol, 10 % PEG 8000 (MORPHEUS 1, F2)
Resolution 2.40 Å R-free 0.265
6SMC mouse Interleukin-12 subunit beta - p80 homodimer in space group P1 Deposited 2019-08-21 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Chain C 1–335（335 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；287 K；200 MM NAFORMATE, 100 MM NAPO4 PH 6.2, 10 % GLYCEROL, 20% MEDIUM PEG SMEAR (BCS CONDITION 40)
Resolution 3.50 Å R-free 0.310
6SMC mouse Interleukin-12 subunit beta - p80 homodimer in space group P1 Deposited 2019-08-21 Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 1–335（335 aa）
Chain D 1–335（335 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；287 K；200 MM NAFORMATE, 100 MM NAPO4 PH 6.2, 10 % GLYCEROL, 20% MEDIUM PEG SMEAR (BCS CONDITION 40)
Resolution 3.50 Å R-free 0.310
6SP3 mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 1 Deposited 2019-08-30 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Chain B 1–335（335 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；287 K；5% MPD, 10% PEG6000, 100mM HEPES pH7.5 (Crystal screen HT condition 78)
Resolution 3.00 Å R-free 0.267
7PUR mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 2 Deposited 2021-09-30 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Chain B 1–335（335 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；287 K；5% MPD, 10% PEG6000, 100mM TRIS pH7.5
Resolution 3.90 Å R-free 0.324
7R3N mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3 Deposited 2022-02-07 Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Chain B 1–335（335 aa）
Not recorded PO4 PHOSPHATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；287 K；BCS screen, 0.2M sodium formate, 0.1M sodium phosphate pH 6.0, 17% PEG Smear Medium, 10% Glycerol. Cryoprotected with up to 27.5% PEG Smear Medium prior to vitrification.
Resolution 3.16 Å R-free 0.258
7R3N mouse Interleukin-12 subunit beta - p80 homodimer in space group P21 crystal form 3 Deposited 2022-02-07 Assembly 2 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 1–335（335 aa）
Chain D 1–335（335 aa）
Not recorded PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；287 K；BCS screen, 0.2M sodium formate, 0.1M sodium phosphate pH 6.0, 17% PEG Smear Medium, 10% Glycerol. Cryoprotected with up to 27.5% PEG Smear Medium prior to vitrification.
Resolution 3.16 Å R-free 0.258
8CR5 Murine Interleukin-12 receptor beta 1 domain 1 in complex with murine Interleukin-12 beta. Deposited 2023-03-07 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Mutation：C197S NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；(BCS E4) 20% PEG smear medium, 0.1M MgCl2, 0.1 M KCl, 0.1M PIPES pH 7.0
Resolution 2.15 Å R-free 0.282
8CR6 mouse Interleukin-12 Deposited 2023-03-07 Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 1–335（335 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；JCSG-plus G4: 0.2 M TMAO, 0.1 M Tris pH 8.5, 20% w/v/ PEG 2000 MME, 20 mM BaCl2
Resolution 2.85 Å R-free 0.296
8ODZ Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1). Deposited 2023-03-10 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 23–335（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 3.60 Å
8OE0 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 2). Deposited 2023-03-10 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 23–335（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 4.60 Å
8PB1 Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. Deposited 2023-06-08 Assembly 1 Insufficient information Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain B 23–335（313 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.4；HEPES-buffered saline (HBS) with added calcium chloride: 25 mM HEPES, pH 7.4, 150 mM NaCl, 5 mM CaCl
cryo-EM vitrification conditions Cryogen ETHANE；Leica EM GP2, 5 s. blotting time.
Resolution 3.50 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.