当前蛋白身份:P55899 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1EXU CRYSTAL STRUCTURE OF THE HUMAN MHC-RELATED FC RECEPTOR 提交 2000-05-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 24–290(267 aa) 片段:EXTRACELLULAR LIGAND BINDING DOMAIN
未记录 BME BETA-MERCAPTOETHANOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.2;295 K;ammonium sulfate, glycerol, tris, pH 8.2, VAPOR DIFFUSION, HANGING DROP, temperature 295.0K
分辨率 2.70 Å R-free 0.247
3M17 Crystal structure of human FcRn with a monomeric peptide inhibitor 提交 2010-03-04 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;277 K;2uL protein:peptide with 2ul solution of 100mM sodium phosphate/citric acid, 20% PEG 3350, 8% ethanol, pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K
分辨率 2.60 Å R-free 0.325
3M17 Crystal structure of human FcRn with a monomeric peptide inhibitor 提交 2010-03-04 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;277 K;2uL protein:peptide with 2ul solution of 100mM sodium phosphate/citric acid, 20% PEG 3350, 8% ethanol, pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K
分辨率 2.60 Å R-free 0.325
3M17 Crystal structure of human FcRn with a monomeric peptide inhibitor 提交 2010-03-04 Assembly 5 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 E 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;277 K;2uL protein:peptide with 2ul solution of 100mM sodium phosphate/citric acid, 20% PEG 3350, 8% ethanol, pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K
分辨率 2.60 Å R-free 0.325
3M17 Crystal structure of human FcRn with a monomeric peptide inhibitor 提交 2010-03-04 Assembly 7 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 G 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;277 K;2uL protein:peptide with 2ul solution of 100mM sodium phosphate/citric acid, 20% PEG 3350, 8% ethanol, pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 277K
分辨率 2.60 Å R-free 0.325
3M1B Crystal structure of human FcRn with a dimeric peptide inhibitor 提交 2010-03-04 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;294 K;2ul protein:peptide with 2ul buffer containing 100 mM phosphate/citric acid, 22% PEG 1000 and 8% ethanol , pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 294K
分辨率 3.10 Å R-free 0.397
3M1B Crystal structure of human FcRn with a dimeric peptide inhibitor 提交 2010-03-04 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;294 K;2ul protein:peptide with 2ul buffer containing 100 mM phosphate/citric acid, 22% PEG 1000 and 8% ethanol , pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 294K
分辨率 3.10 Å R-free 0.397
3M1B Crystal structure of human FcRn with a dimeric peptide inhibitor 提交 2010-03-04 Assembly 5 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 E 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;294 K;2ul protein:peptide with 2ul buffer containing 100 mM phosphate/citric acid, 22% PEG 1000 and 8% ethanol , pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 294K
分辨率 3.10 Å R-free 0.397
3M1B Crystal structure of human FcRn with a dimeric peptide inhibitor 提交 2010-03-04 Assembly 7 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 G 24–290(267 aa) 片段:UNP residues 24-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;294 K;2ul protein:peptide with 2ul buffer containing 100 mM phosphate/citric acid, 22% PEG 1000 and 8% ethanol , pH 4.2, VAPOR DIFFUSION, SITTING DROP, temperature 294K
分辨率 3.10 Å R-free 0.397
4K71 Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor 提交 2013-04-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 24–297(274 aa) 片段:UNP residues 24-297
未记录 SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.9;293 K;1.7 M ammonium sulfate, 0.1 M sodium citrate, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.40 Å R-free 0.255
4K71 Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor 提交 2013-04-16 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 24–297(274 aa) 片段:UNP residues 24-297
未记录 SO4 SULFATE ION × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.9;293 K;1.7 M ammonium sulfate, 0.1 M sodium citrate, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.40 Å R-free 0.255
4K71 Crystal structure of a high affinity Human Serum Albumin variant bound to the Neonatal Fc Receptor 提交 2013-04-16 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 12 PDB 声明:dodecameric(12) 与蛋白数一致
链 B 24–297(274 aa) 片段:UNP residues 24-297
链 E 24–297(274 aa) 片段:UNP residues 24-297
未记录 SO4 SULFATE ION × 38 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.9;293 K;1.7 M ammonium sulfate, 0.1 M sodium citrate, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 293K
分辨率 2.40 Å R-free 0.255
4N0F Human FcRn complexed with human serum albumin 提交 2013-10-01 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 27–297(271 aa) 片段:unp residues 27-297
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.2;298 K;4% Tacsimate, pH 4.0, 12% PEG3350, 30 mM Sodium Acetate, pH 5.2, HSA/FcRn 10 mg/ml, VAPOR DIFFUSION, temperature 298K
分辨率 3.02 Å R-free 0.260
4N0F Human FcRn complexed with human serum albumin 提交 2013-10-01 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 E 27–297(271 aa) 片段:unp residues 27-297
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.2;298 K;4% Tacsimate, pH 4.0, 12% PEG3350, 30 mM Sodium Acetate, pH 5.2, HSA/FcRn 10 mg/ml, VAPOR DIFFUSION, temperature 298K
分辨率 3.02 Å R-free 0.260
4N0F Human FcRn complexed with human serum albumin 提交 2013-10-01 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 H 27–297(271 aa) 片段:unp residues 27-297
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.2;298 K;4% Tacsimate, pH 4.0, 12% PEG3350, 30 mM Sodium Acetate, pH 5.2, HSA/FcRn 10 mg/ml, VAPOR DIFFUSION, temperature 298K
分辨率 3.02 Å R-free 0.260
4N0F Human FcRn complexed with human serum albumin 提交 2013-10-01 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 K 27–297(271 aa) 片段:unp residues 27-297
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.2;298 K;4% Tacsimate, pH 4.0, 12% PEG3350, 30 mM Sodium Acetate, pH 5.2, HSA/FcRn 10 mg/ml, VAPOR DIFFUSION, temperature 298K
分辨率 3.02 Å R-free 0.260
4N0U Ternary complex between Neonatal Fc receptor, serum albumin and Fc 提交 2013-10-02 Assembly 1 其他组合 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 A 27–290(264 aa) 片段:FcRn, alpha chain, ecd, unp residue 27-290
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.2;298 K;4% Tacsimate, pH 4.0, 12% PEG 3350, VAPOR DIFFUSION, temperature 298K
分辨率 3.80 Å R-free 0.303
5BJT Crystal structure of human FcRn with a peptide inhibitor at multiple sites 提交 2016-10-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 24–290(267 aa) 片段:extracellular domain (UNP residues 24-290)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.7;277 K;1.6 M ammonium sulfate, 20% glycerol, 0.8 M sodium acetate
分辨率 3.20 Å R-free 0.339
5BJT Crystal structure of human FcRn with a peptide inhibitor at multiple sites 提交 2016-10-23 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 24–290(267 aa) 片段:extracellular domain (UNP residues 24-290)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.7;277 K;1.6 M ammonium sulfate, 20% glycerol, 0.8 M sodium acetate
分辨率 3.20 Å R-free 0.339
5BJT Crystal structure of human FcRn with a peptide inhibitor at multiple sites 提交 2016-10-23 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 E 24–290(267 aa) 片段:extracellular domain (UNP residues 24-290)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.7;277 K;1.6 M ammonium sulfate, 20% glycerol, 0.8 M sodium acetate
分辨率 3.20 Å R-free 0.339
5BJT Crystal structure of human FcRn with a peptide inhibitor at multiple sites 提交 2016-10-23 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 G 24–290(267 aa) 片段:extracellular domain (UNP residues 24-290)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.7;277 K;1.6 M ammonium sulfate, 20% glycerol, 0.8 M sodium acetate
分辨率 3.20 Å R-free 0.339
5BXF Apo FcRn Structure at pH 4.5 提交 2015-06-08 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–290(290 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;298 K;.1M sodium citrate pH 4.5, 20% PEG (4000)
分辨率 2.85 Å R-free 0.314
5BXF Apo FcRn Structure at pH 4.5 提交 2015-06-08 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–290(290 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;298 K;.1M sodium citrate pH 4.5, 20% PEG (4000)
分辨率 2.85 Å R-free 0.314
5WHK Crystal structure of Fab fragment of antibody DX-2507 bound to FcRn-B2M 提交 2017-07-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–297(297 aa)
未记录 EDO 1,2-ETHANEDIOL × 2 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;289 K;DX-2507 Fab FcRn B2M complex at 6.6 mg/mL at 70 uM against an optimization screen against JCSG+ A7 18% PEG 8000, 0.1 M CHES pH 9.8 with seeding from an earlier crystal obtained under similar conditions, supplemented with 20% ethylene glycol as cro-protectant
分辨率 2.50 Å R-free 0.225
6C97 Crystal structure of FcRn at pH3 提交 2018-01-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 24–297(274 aa)
未记录 GOL GLYCEROL × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.01-3.09 AND 12-16% W/V PEG 6,000.
分辨率 2.00 Å R-free 0.210
6C97 Crystal structure of FcRn at pH3 提交 2018-01-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.01-3.09 AND 12-16% W/V PEG 6,000.
分辨率 2.00 Å R-free 0.210
6C98 Crystal structure of FcRn bound to UCB-84 提交 2018-01-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 24–297(274 aa)
未记录 CYS CYSTEINE × 1 ER7 1-[7-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethan-1-one × 1 GOL GLYCEROL × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0 AND 20% W/V PEG 6,000. CRYSTALS OF FCRN WERE SOAKED FOR THREE DAYS IN BUFFER CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0, 20% W/V PEG 6,000, AND 20% GLYCEROL AND 20MM UCB-84).
分辨率 1.85 Å R-free 0.213
6C98 Crystal structure of FcRn bound to UCB-84 提交 2018-01-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 24–297(274 aa)
未记录 CYS CYSTEINE × 1 ER7 1-[7-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]ethan-1-one × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0 AND 20% W/V PEG 6,000. CRYSTALS OF FCRN WERE SOAKED FOR THREE DAYS IN BUFFER CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0, 20% W/V PEG 6,000, AND 20% GLYCEROL AND 20MM UCB-84).
分辨率 1.85 Å R-free 0.213
6C99 Crystal structure of FcRn bound to UCB-303 提交 2018-01-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 24–297(274 aa)
未记录 EQY methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 GOL GLYCEROL × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.01-3.09 AND 12-16% W/V PEG 6,000. CRYSTALS OF FCRN WERE SOAKED FOR THREE DAYS IN BUFFER CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0, 20% W/V PEG6,000, AND 20% GLYCEROL AND 12.5MM UCB-303.
分辨率 2.00 Å R-free 0.220
6C99 Crystal structure of FcRn bound to UCB-303 提交 2018-01-25 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 24–297(274 aa)
未记录 EQY methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate × 1 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 3;289 K;APO FCRN CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR DIFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN COMPLEX, PROVIDED IN A PROTEIN SOLUTION CONTAINING 50MM HEPES PH 7.0 AND 75MM NACL, AND AN OPTIMIZATION SCREEN CONTAINING 0.1M CITRIC ACID/NAOH PH 3.01-3.09 AND 12-16% W/V PEG 6,000. CRYSTALS OF FCRN WERE SOAKED FOR THREE DAYS IN BUFFER CONTAINING 0.1M CITRIC ACID/NAOH PH 3.0, 20% W/V PEG6,000, AND 20% GLYCEROL AND 12.5MM UCB-303.
分辨率 2.00 Å R-free 0.220
6FGB Human FcRn extra-cellular domain complexed with Fab fragment of Rozanolixizumab 提交 2018-01-10 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 24–365(342 aa)
未记录 CL CHLORIDE ION × 2 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;291.15 K;0.1M Sodium citrate pH 5.5, 11% PEG6000
分辨率 2.90 Å R-free 0.284
6ILM Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 提交 2018-10-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 360 PDB 声明:540-meric(540) 待复核
链 E 28–290(263 aa)
未记录 SPH SPHINGOSINE × 60 K POTASSIUM ION × 60 NA SODIUM ION × 60 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
6ILM Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 提交 2018-10-19 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:nonameric(9) 待复核
链 E 28–290(263 aa)
未记录 SPH SPHINGOSINE × 1 K POTASSIUM ION × 1 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
6ILM Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 提交 2018-10-19 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 30 PDB 声明:45-meric(45) 待复核
链 E 28–290(263 aa)
未记录 SPH SPHINGOSINE × 5 K POTASSIUM ION × 5 NA SODIUM ION × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
6ILM Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 提交 2018-10-19 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 36 PDB 声明:54-meric(54) 待复核
链 E 28–290(263 aa)
未记录 SPH SPHINGOSINE × 6 K POTASSIUM ION × 6 NA SODIUM ION × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
6ILM Cryo-EM structure of Echovirus 6 complexed with its uncoating receptor FcRn at PH 7.4 提交 2018-10-19 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:nonameric(9) 待复核
链 E 28–290(263 aa)
未记录 SPH SPHINGOSINE × 1 K POTASSIUM ION × 1 NA SODIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
6LA6 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 提交 2019-11-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 360 PDB 声明:360-meric(360) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.39 Å
6LA6 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 提交 2019-11-12 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.39 Å
6LA6 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 提交 2019-11-12 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 30 PDB 声明:30-meric(30) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.39 Å
6LA6 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 提交 2019-11-12 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 36 PDB 声明:36-meric(36) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.39 Å
6LA6 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4 提交 2019-11-12 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.39 Å
6LA7 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5 提交 2019-11-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 360 PDB 声明:360-meric(360) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.82 Å
6LA7 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5 提交 2019-11-12 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.82 Å
6LA7 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5 提交 2019-11-12 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 30 PDB 声明:30-meric(30) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.82 Å
6LA7 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5 提交 2019-11-12 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 36 PDB 声明:36-meric(36) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.82 Å
6LA7 Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 5.5 提交 2019-11-12 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.82 Å
6NHA Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody 提交 2018-12-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 24–296(273 aa)
未记录 NHE 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 9.5;277.15 K;0.1M CHES pH 9.5 50% polyethylene glycol 200
分辨率 2.38 Å R-free 0.245
6QIO Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan 提交 2019-01-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 24–297(274 aa)
未记录 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 CYS CYSTEINE × 2 JG5 Somapacitan × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5;293 K;ammonium acetate, sodium acetate, PEG4000
分辨率 1.95 Å R-free 0.226
6QIP Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the albumin-biniding side chain of the human growth hormone derivative somapacitan 提交 2019-01-21 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 24–297(274 aa)
未记录 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 JG5 Somapacitan × 1 BME BETA-MERCAPTOETHANOL × 1 CYS CYSTEINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293 K;sodium cacodylate, PEG3350
分辨率 2.45 Å R-free 0.259
6WNA Next generation monomeric IgG4 Fc 提交 2020-04-22 Assembly 1 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 27–290(264 aa) 片段:extracellular region
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;295 K;0.2 M magnesium chloride hexahydrate, 30% 1,5-diaminopentane dihydrochloride, 0.1 M MES, pH 6 and 20% PEG 6000 at a protein concentration of 6 mg/mL
分辨率 2.40 Å R-free 0.263
6WOL Next generation monomeric IgG4 Fc bound to neonatal Fc receptor 提交 2020-04-24 Assembly 1 其他组合 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 24–290(267 aa) 片段:extracellular domain
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;295 K;0.2 M magnesium chloride hexahydrate, 1 M sodium iodide, 0.1 M MES, pH 6 and 20% PEG 6000 at a protein concentration of 6.35 mg/mL
分辨率 2.49 Å R-free 0.270
7B5F Structure of echovirus 18 in complex with neonatal Fc receptor 提交 2020-12-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:Hexameric(6) 与蛋白数一致
链 G 24–290(267 aa)
未记录 PLM PALMITIC ACID × 1 GUN GUANINE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.3;Mixed in 1:1 volume ratio {20 mM Tris (pH=7.2), 100 mM NaCl} and {8 mM Na2HPO4, 2 mM KH2PO4 (pH=7.4), 137 mM NaCl, 2.7 mM KCl}=PBS
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.90 Å R-free 0.311
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 360 PDB 声明:360-meric(360) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 60 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 30 PDB 声明:30-meric(30) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 5 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 36 PDB 声明:36-meric(36) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7C9V E30 F-particle in complex with FcRn 提交 2020-06-07 Assembly 6 蛋白异源复合物 异源复合物;蛋白 × 360 PDB 声明:360-meric(360) 与蛋白数一致
链 E 28–290(263 aa)
未记录 MYR MYRISTIC ACID × 60 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å
7Q15 Crystal structure of FcRn and beta-2-microglobulin in complex with IgG1-Fc-MST-HN (efgartigimod) 提交 2021-10-18 Assembly 1 其他组合 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–297(297 aa)
链 C 1–297(297 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;294 K;0.1 M Sodium Cacodylate pH 7
分辨率 3.30 Å R-free 0.231
7XXA Complex of Echo 18 and FcRn at pH7.4 提交 2022-05-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 300 PDB 声明:300-meric(300) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE;blot for 3 seconds and wait for 3 seconds before plunging
分辨率 3.09 Å
7XXA Complex of Echo 18 and FcRn at pH7.4 提交 2022-05-29 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE;blot for 3 seconds and wait for 3 seconds before plunging
分辨率 3.09 Å
7XXA Complex of Echo 18 and FcRn at pH7.4 提交 2022-05-29 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 25 PDB 声明:25-meric(25) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE;blot for 3 seconds and wait for 3 seconds before plunging
分辨率 3.09 Å
7XXA Complex of Echo 18 and FcRn at pH7.4 提交 2022-05-29 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 30 PDB 声明:30-meric(30) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE;blot for 3 seconds and wait for 3 seconds before plunging
分辨率 3.09 Å
7XXA Complex of Echo 18 and FcRn at pH7.4 提交 2022-05-29 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 E 28–290(263 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE;blot for 3 seconds and wait for 3 seconds before plunging
分辨率 3.09 Å
9DBT Crystal structure of human astrovirus 1 capsid spike bound to human neonatal Fc receptor 提交 2024-08-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 24–297(274 aa)
链 F 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.1;295.15 K;Sodium chloride, Ammonium sulfate, BIS-TRIS
分辨率 3.40 Å R-free 0.263
9DBT Crystal structure of human astrovirus 1 capsid spike bound to human neonatal Fc receptor 提交 2024-08-23 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 24–297(274 aa)
链 I 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.1;295.15 K;Sodium chloride, Ammonium sulfate, BIS-TRIS
分辨率 3.40 Å R-free 0.263
9MI6 Crystal structure of human FcRn in complex with nipocalimab Fab fragment 提交 2024-12-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 24–297(274 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277.15 K;10% PEG 1000, 10% PEG 8000
分辨率 2.41 Å R-free 0.248
9NAV CryoEM structure of human astrovirus 1 spike in complex with human neonatal Fc receptor 提交 2025-02-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致
链 G 24–290(267 aa)
链 I 24–290(267 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.81 Å
9OC6 Crystal structure of receptor FcRn bound to Human Astrovirus 6 spike 提交 2025-04-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;293 K;0.1M HEPES, 30% 1,2-propanediol, 20% PEG-400
分辨率 2.97 Å R-free 0.281
9OC7 Crystal structure of FcRn in complex with Human Astrovirus 2 spike 提交 2025-04-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 E 24–297(274 aa)
链 Y 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.9;293 K;25% 1,2-propanediol, 10% glycerol, 5% PEG-3000, 0.1 M phosphate-citrate
分辨率 3.07 Å R-free 0.239
9WYD Crystal structure of HAstV8 spike and FcRn 提交 2025-09-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 24–297(274 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 LIQUID DIFFUSION;291.15 K;0.1 M BICINE pH 8.5, 8% w/v Polyethylene glycol monomethyl ether 5,000
分辨率 2.65 Å R-free 0.232