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6la6

Cryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

IgG receptor FcRn large subunit p51

Homo sapiens

UniProt P55899

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 360 Capsid protein VP1 × 60 Capsid protein VP2 × 60 Capsid protein VP3 × 60 Capsid protein VP4 × 60 Beta-2-microglobulin × 60 （P61769） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 6 Capsid protein VP1 × 1 Capsid protein VP2 × 1 Capsid protein VP3 × 1 Capsid protein VP4 × 1 Beta-2-microglobulin × 1 （P61769） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 30 Capsid protein VP1 × 5 Capsid protein VP2 × 5 Capsid protein VP3 × 5 Capsid protein VP4 × 5 Beta-2-microglobulin × 5 （P61769） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 36 Capsid protein VP1 × 6 Capsid protein VP2 × 6 Capsid protein VP3 × 6 Capsid protein VP4 × 6 Beta-2-microglobulin × 6 （P61769） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 6 Capsid protein VP1 × 1 Capsid protein VP2 × 1 Capsid protein VP3 × 1 Capsid protein VP4 × 1 Beta-2-microglobulin × 1 （P61769） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3m17 3m17 3m17 3m17 3m1b 3m1b 3m1b 3m1b

8 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1exu 4k71 4k71 4k71 4n0f 4n0f 4n0f 4n0f 4n0u 5bjt 5bjt 5bjt

63 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FCGRN_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain E； PDBConstruct 1–263； UniProt 28–290

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 360 Capsid protein VP1 × 60 Capsid protein VP2 × 60 Capsid protein VP3 × 60 Capsid protein VP4 × 60 IgG receptor FcRn large subunit p51 × 60 （P55899） Consistent with protein count
2 Protein heterocomplex Heteromer Protein 6 Capsid protein VP1 × 1 Capsid protein VP2 × 1 Capsid protein VP3 × 1 Capsid protein VP4 × 1 IgG receptor FcRn large subunit p51 × 1 （P55899） Consistent with protein count
3 Protein heterocomplex Heteromer Protein 30 Capsid protein VP1 × 5 Capsid protein VP2 × 5 Capsid protein VP3 × 5 Capsid protein VP4 × 5 IgG receptor FcRn large subunit p51 × 5 （P55899） Consistent with protein count
4 Protein heterocomplex Heteromer Protein 36 Capsid protein VP1 × 6 Capsid protein VP2 × 6 Capsid protein VP3 × 6 Capsid protein VP4 × 6 IgG receptor FcRn large subunit p51 × 6 （P55899） Consistent with protein count
5 Protein heterocomplex Heteromer Protein 6 Capsid protein VP1 × 1 Capsid protein VP2 × 1 Capsid protein VP3 × 1 Capsid protein VP4 × 1 IgG receptor FcRn large subunit p51 × 1 （P55899） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 6
Chains and sequence ranges Author chain F； PDBConstruct 1–99； UniProt 21–119

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id6la6
Deposition date deposition_date2019-11-12
Structure title titleCryo-EM structure of echovirus 11 complexed with its uncoating receptor FcRn at pH 7.4
Keywords keywordsCryo-EM structure, echovirus 11, FcRn, VIRUS; VIRUS
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

6la6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

6la6__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 1011 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

6la6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）0.00 Å
Rg (electron density)148.80 Å
Total Rg148.70 Å
Atom count564780
Residues71700
Excluded volume9989600 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 6la6__assembly_1__model_1 360-meric （360） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 6la6__assembly_2__model_1 hexameric （6） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
3 1 6la6__assembly_3__model_1 30-meric （30） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
4 1 6la6__assembly_4__model_1 36-meric （36） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
5 1 6la6__assembly_5__model_1 hexameric （6） Excluded — —
Exclusion reason： Auxiliary symmetry representation; not a complete or representative biological assembly.
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 5 domains

SCOP 2.08 (5 domains)

Domain ID domain_idd6la6a_
Class classb — All beta proteins
Fold Fold foldb.121 — Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily Superfamily superfamilyb.121.4 — Positive stranded ssRNA viruses
Family Family familyb.121.4.1 — Picornaviridae-like VP (VP1, VP2, VP3 and VP4)
Domain ID domain_idd6la6c_
Class classb — All beta proteins
Fold Fold foldb.121 — Nucleoplasmin-like/VP (viral coat and capsid proteins)
Superfamily Superfamily superfamilyb.121.4 — Positive stranded ssRNA viruses
Family Family familyb.121.4.1 — Picornaviridae-like VP (VP1, VP2, VP3 and VP4)
Domain ID domain_idd6la6e1
Class classd — Alpha and beta proteins (a+b)
Fold Fold foldd.19 — MHC antigen-recognition domain
Superfamily Superfamily superfamilyd.19.1 — MHC antigen-recognition domain
Family Family familyd.19.1.1 — MHC antigen-recognition domain
Domain ID domain_idd6la6e2
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.0 — automated matches
Domain ID domain_idd6la6f_
Class classb — All beta proteins
Fold Fold foldb.1 — Immunoglobulin-like beta-sandwich
Superfamily Superfamily superfamilyb.1.1 — Immunoglobulin
Family Family familyb.1.1.2 — C1 set domains (antibody constant domain-like)
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7. Citations (1)