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8enh

Cross-reactive 3180 TCR recognition of HLA-B*35:01-NP7 epitope from 2002 H3N2 influenza strain

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

MHC class I antigen

Homo sapiens

UniProt F4NBT2

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 5 Beta-2-microglobulin × 1 （P61769） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
7sig 8emf 8emg 8emi 8emj 8emk 8en8 8en8 8enh 8enh 8enh 8enh

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name F4NBT2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–276； UniProt 25–300 Author chain F； PDBConstruct 1–276； UniProt 25–300 Author chain K； PDBConstruct 1–276； UniProt 25–300 Author chain P； PDBConstruct 1–276； UniProt 25–300

Beta-2-microglobulin

Homo sapiens

UniProt P61769

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 5 MHC class I antigen × 1 （F4NBT2） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 5 MHC class I antigen × 1 （F4NBT2） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 5 MHC class I antigen × 1 （F4NBT2） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 5 MHC class I antigen × 1 （F4NBT2） Nucleoprotein NP7 epitope × 1 3180 TCR alpha chain × 1 3180 TCR alpha chain × 1 water × 5 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1jnj 1lds 1py4 1py4 1py4 1py4 2d4d 2d4f 2vb5 2xks 2xku 2yxf

61 assemblies; showing the first 12

Homodimer
2x89 2x89 2z9t 3low 4r9h 4r9h 4ra3 4ra3 4rah 6m1b

10 assemblies

Homotetramer
2e8d 2f8o 3tlr 3tm6 3tm6 7afv

6 assemblies

Other homooligomers
3ciq 3ciq 3loz 6gk3 8a7o 8a7p 8a7q 8a7t

8 assemblies

Heteromeric or nucleic-acid complex
1a1m 1a1n 1a1o 1a6z 1a6z 1a9b 1a9b 1a9e 1agb 1agc 1agd 1age

1914 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name B2MG_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 2–100； UniProt 21–119 Author chain G； PDBConstruct 2–100； UniProt 21–119 Author chain L； PDBConstruct 2–100； UniProt 21–119 Author chain Q； PDBConstruct 2–100； UniProt 21–119

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8enh
Deposition date deposition_date2022-09-30
Structure title titleCross-reactive 3180 TCR recognition of HLA-B*35:01-NP7 epitope from 2002 H3N2 influenza strain
Keywords keywordsHLA B*3501, NP418 EPITOPE, T CELL IMMUNITY, GLYCOPROTEIN, HOST-VIRUS INTERACTION, IMMUNE RESPONSE, IMMUNE SYSTEM; IMMUNE SYSTEM
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8enh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8enh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8enh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）37.59 Å
Rg (electron density)37.81 Å
Total Rg37.91 Å
Atom count6681
Residues833
Excluded volume117160 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8enh__assembly_1__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 8enh__assembly_2__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 8enh__assembly_3__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 8enh__assembly_4__model_1 pentameric （5） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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7. Citations (1)