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1efx

STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3

Method: X-RAY DIFFRACTION D_max: 143.7 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1efx
deposition_date	2000-02-10
title	STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3
keywords	MHC, HLA, class I, KIR, NK cell receptor, Immunoglobulin fold, receptor-MHC complex, IMMUNE SYSTEM; IMMUNE SYSTEM
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	40.45 Å
rg_electron	40.64 Å
i0	126858000.00
molecular_weight	88188.0 kDa
excluded_volume	109020 Å³
envelope_volume	162110 Å³
shell_volume	36380 Å³
envelope_diameter	142.8 Å
shell_rg	41.40 Å
envelope_rg	40.50 Å
shape_rg	40.63 Å
total_rg	40.73 Å
total_atoms	6226
n_residues	781
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	143.7 Å
rg_real	40.80 Å
rg_real_error	2.10 Å
i0_real	1.2690e+08
i0_real_error	2.7740e+06
rg_reciprocal	40.45 Å
i0_reciprocal	126800000.0000
total_estimate	0.8034
solution_quality	GOOD a GOOD solution
n_peaks	1
r_peak_primary	33.2 Å
skewness	0.500
kurtosis	-0.420
angular_range	— – 0.1950 Å⁻¹
current_alpha	0.0000
highest_alpha	7138000.0000
n_real_points	40
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.714; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.482; Smooth: 0.816

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4. Crystallography & Experiment

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5. Entities & Polymer Info (5)

Entity 1 polymer

description	HLA-CW3 (HEAVY CHAIN)
formula_weight	32185.4 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	6411

GSHSMRYFYTAVSRPGRGEPHFIAVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHIIQRMYGCDVGPDGRLLRGYDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQLRAYLEGLCVEWLRRYLKNGKETLQRAEHPKTHVTHHPVSDHEATLRCWALGFYPAEITLTWQWDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLTLRWEPSS

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 polymer

description	BETA-2-MICROGLOBULIN
formula_weight	11879.4 kDa
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	B

MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 3 polymer

description	PEPTIDE FROM IMPORTIN ALPHA-2
formula_weight	868.0 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	C

GAVDPLLAL

Entity 4 polymer

description	NATURAL KILLER CELL RECEPTOR KIR2DL2
formula_weight	22050.7 kDa
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	D,E

HEGVHRKPSLLAHPGRLVKSEETVILQCWSDVRFEHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHECRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVI

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 5 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	185

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6. Citations (2)

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length_a	68.540 Å
length_b	90.330 Å
length_c	207.270 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	3.000 Å
resolution_low	10.000 Å
r_factor	0.2090
r_work	0.2310
r_free	0.2940

fit	/app/data/saxs_computation/ef/1efx/1efx.fit
pddf	/app/data/pr_computation/ef/1efx/1efx.pr.out
profile	/app/data/saxs_computation/ef/1efx/1efx.dat

STRUCTURE OF A COMPLEX BETWEEN THE HUMAN NATURAL KILLER CELL RECEPTOR KIR2DL2 AND A CLASS I MHC LIGAND HLA-CW3

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction

5. Entities & Polymer Info (5)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Source

Entity 3 polymer

Polymer

Entity 4 polymer

Polymer

Source

Entity 5 water

6. Citations (2)

7. Files & Curves (10)

Files (7)

Curves (3)