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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：P61812 New Search
10PDB entries
12Biological assembly
18chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1TFG AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2 Deposited 1992-11-17 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 303–414（112 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å
2TGI CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY Deposited 1993-10-20 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 303–414（112 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
4KXZ crystal structure of tgfb2 in complex with GC2008. Deposited 2013-05-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 303–414（112 aa） Fragment：unp residues 303-414
Chain B 303–414（112 aa） Fragment：unp residues 303-414
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；296 K；35% PEG400, 100mM MES, VAPOR DIFFUSION, temperature 296K, pH 6.0
Resolution 2.83 Å R-free 0.222
4KXZ crystal structure of tgfb2 in complex with GC2008. Deposited 2013-05-28 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain D 303–414（112 aa） Fragment：unp residues 303-414
Chain E 303–414（112 aa） Fragment：unp residues 303-414
Not recorded MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 3 PE5 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 6；296 K；35% PEG400, 100mM MES, VAPOR DIFFUSION, temperature 296K, pH 6.0
Resolution 2.83 Å R-free 0.222
5TX4 Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130 Deposited 2016-11-15 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 303–414（112 aa） Fragment：UNP residues 303-414
Mutation：deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；0.1 M Hepes, pH 7.5, 60 % v/v (+/-)-2-Methyl-2,4-pentanediol
Resolution 1.88 Å R-free 0.222
6I9J Human transforming growth factor beta2 in a tetragonal crystal form Deposited 2018-11-23 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 331–442（112 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；20% isopropanol, 0.2M calcium chloride, 0.1M sodium acetate pH 4.6
Resolution 2.00 Å R-free 0.253
6XM2 The structure of the 4A11.v7 antibody in complex with human TGFb2 Deposited 2020-06-29 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain K 303–414（112 aa） Fragment：mature domain
Chain L 303–414（112 aa） Fragment：mature domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；20% PEG 1000, 0.1 M Tris pH8.5
Resolution 1.91 Å R-free 0.244
6XM2 The structure of the 4A11.v7 antibody in complex with human TGFb2 Deposited 2020-06-29 Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain I 303–414（112 aa） Fragment：mature domain
Chain J 303–414（112 aa） Fragment：mature domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；292 K；20% PEG 1000, 0.1 M Tris pH8.5
Resolution 1.91 Å R-free 0.244
7RCO Crystal structure of human TGF-beta-2 bound to 4A11.V2 Fab Deposited 2021-07-07 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 303–414（112 aa） Fragment：mature domain (UNP residues 303-414)
Chain B 303–414（112 aa） Fragment：mature domain (UNP residues 303-414)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；15% PEG4000, 0.1 M sodium cacodylate, pH 6.0
Resolution 2.90 Å R-free 0.286
8DC0 Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R) Deposited 2022-06-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 303–414（112 aa） Fragment：mmTGF-b2-7m2r (UNP residues 303-414)
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.6；298 K；13% PEG4000, 0.1 M trisodium citrate, 10% ethylene glycol
Resolution 1.93 Å R-free 0.257
8FXS Crystal structure of human pro-TGF-beta2 in complex with Nb9 Deposited 2023-01-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 21–414（394 aa）
Chain B 21–414（394 aa）
Mutation：C24S, N140R, R298_R303delinsG Mutation：C24S, N140R, R298_R303delinsG NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；Crystals of the Nb9/proTGF-beta2 complex (1 microliter) were formed in hanging drops with 1 microliter of 100 mM HEPES pH 7.6, 10% PEG 4000.
Resolution 3.15 Å R-free 0.301
8FXV Crystal structure of human proTGF-beta2 in complex with Nb18 Deposited 2023-01-25 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 21–414（394 aa）
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；Crystals of the Nb18/proTGF-beta2 complex (1 microliter) were formed in hanging drops with 1 microliter of 100 mM HEPES pH 7.4, 26.7% Jeffamine ED2001.
Resolution 2.20 Å R-free 0.249

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.