Current Protein Identity：P62508
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1KV6 X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation Deposited 2002-01-25 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：ligand-binding domain
Chain B
229–458（230 aa）
Fragment：ligand-binding domain
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；Tris.HCl, ammonium sulfate, glycerol, pH 8.0, VAPOR DIFFUSION, HANGING DROP at 277K
|
Resolution 2.70 Å R-free 0.267 |
| 1TFC CRYSTAL STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE ESTROGEN-RELATED RECEPTOR GAMMA IN COMPLEX WITH A STEROID RECEPTOR COACTIVATOR-1 PEPTIDE Deposited 2004-05-27 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：LIGAND-BINDING DOMAIN
Chain B
229–458（230 aa）
Fragment：LIGAND-BINDING DOMAIN
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；TRIS.HCL, AMMONIUM SULFATE,
GLYCEROL, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.40 Å R-free 0.258 |
| 2E2R Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol A Deposited 2006-11-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：ligand binding domain, residues 232-459
|
Not recorded | 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 2 GOL GLYCEROL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.60 Å R-free 0.197 |
| 2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
233–458（226 aa）
Chain B
233–458（226 aa）
|
Not recorded | TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.30 Å R-free 0.247 |
| 2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
233–458（226 aa）
Chain D
233–458（226 aa）
|
Not recorded | TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.30 Å R-free 0.247 |
| 2EWP Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182 Deposited 2005-11-04 | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain E
233–458（226 aa）
|
Not recorded | TXF (Z)-4-(1-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-HYDROXY-2-PHENYLPENT-1-ENYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；0.2M sodium Citrate, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP
|
Resolution 2.30 Å R-free 0.247 |
| 2GP7 Estrogen Related Receptor-gamma ligand binding domain Deposited 2006-04-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：Residues 229-458
Chain B
229–458（230 aa）
Fragment：Residues 229-458
|
Not recorded | CA CALCIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.1m Tris pH8.0
15mM CaCl2
30% PEG600
2% PEG35K, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.45 Å R-free 0.263 |
| 2GP7 Estrogen Related Receptor-gamma ligand binding domain Deposited 2006-04-17 | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain C
229–458（230 aa）
Fragment：Residues 229-458
Chain D
229–458（230 aa）
Fragment：Residues 229-458
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；0.1m Tris pH8.0
15mM CaCl2
30% PEG600
2% PEG35K, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.45 Å R-free 0.263 |
| 2GPO Estrogen Related Receptor-gamma ligand binding domain complexed with a synthetic peptide from RIP140 Deposited 2006-04-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：Ligand Binding Domain (Residues 229-458)
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；295 K；14% PEG 3350
0.2M sodium formate, pH 7.2, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 1.95 Å R-free 0.231 |
| 2GPP Estrogen Related Receptor-gamma ligand binding domain complexed with a RIP140 peptide and synthetic ligand GSK4716 Deposited 2006-04-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：Residues (229-458)
Chain B
229–458（230 aa）
Fragment：Residues (229-458)
|
Not recorded | 1BA 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；9% PEG 20K 0.1M MES buffer, pH 7.5, vapor diffusion, hanging drop, temperature 295K
|
Resolution 2.60 Å R-free 0.257 |
| 2GPU Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen Deposited 2006-04-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：Ligand Binding Domain (Residues 229-458)
|
Not recorded | OHT 4-HYDROXYTAMOXIFEN × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；283 K；36% Peg600, 0.1M tris, 0.1% zwittergent 3-16, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 283K
|
Resolution 1.70 Å R-free 0.195 |
| 2GPV Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide Deposited 2006-04-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
Chain B
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
Chain D
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
Chain E
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
|
Not recorded | OHT 4-HYDROXYTAMOXIFEN × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；7% PEG3350
0.2M Lithium Acetate, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.85 Å R-free 0.279 |
| 2GPV Estrogen Related Receptor-gamma ligand binding domain complexed with 4-hydroxy-tamoxifen and a SMRT peptide Deposited 2006-04-18 | Assembly 2 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain C
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
Chain F
229–458（230 aa）
Fragment：Ligand Binding Domain (residues 229-458)
|
Not recorded | OHT 4-HYDROXYTAMOXIFEN × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.8；293 K；7% PEG3350
0.2M Lithium Acetate, pH 7.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.85 Å R-free 0.279 |
| 2P7A Crystal Structure of Estrogen Related Receptor g in complex with 3-methyl phenol Deposited 2007-03-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | 43M 4-CHLORO-3-METHYLPHENOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris pH 8.5 and 0.2M Sodium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.30 Å R-free 0.256 |
| 2P7G X-ray Structure of Estrogen Related Receptor g in complex with Bisphenol A. Deposited 2007-03-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | NA SODIUM ION × 1 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris, pH 8.5 and 0.2M Sodium Acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.10 Å R-free 0.260 |
| 2P7Z Estrogen Related Receptor Gamma in complex with 4-hydroxy-tamoxifen Deposited 2007-03-21 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | OHT 4-HYDROXYTAMOXIFEN × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；22.6% polyethylene glycol 4000, 0.1M Tris pH 8.5 and 0.2M sodium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.263 |
| 2ZAS Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative Deposited 2007-10-09 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：ligand binding domain, UNP residues 222-459
|
Not recorded | 1OH 4-(1-methyl-1-phenylethyl)phenol × 2 GOL GLYCEROL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
|
Resolution 2.00 Å R-free 0.237 |
| 2ZBS Crystal structure of human estrogen-related receptor gamma ligand binding domain apo form Deposited 2007-10-27 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：ligand binding domain, residues 222-459
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293.4 K；VAPOR DIFFUSION, HANGING DROP, temperature 293.4K
|
Resolution 1.80 Å R-free 0.244 |
| 2ZKC Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with bisphenol Z Deposited 2008-03-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：ligand binding domain, UNP residues 222-459
|
Not recorded | BPZ 4,4'-cyclohexane-1,1-diyldiphenol × 2 GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.70 Å R-free 0.234 |
| 5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
|
Resolution 2.50 Å R-free 0.243 |
| 5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
222–458（237 aa）
|
Not recorded | 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
|
Resolution 2.50 Å R-free 0.243 |
| 5YSO Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domain with DN200434 Deposited 2017-11-14 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
222–458（237 aa）
|
Not recorded | 90C 4-[5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.2M Ammonium fluoride, 20%(w/v) PEG 3350, 10mM Barium chloride dihydrate
|
Resolution 2.50 Å R-free 0.243 |
| 6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：UNP residues 222-458
|
Not recorded | 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
|
Resolution 2.90 Å R-free 0.263 |
| 6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
222–458（237 aa）
Fragment：UNP residues 222-458
|
Not recorded | 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
|
Resolution 2.90 Å R-free 0.263 |
| 6A6K Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000 Deposited 2018-06-28 | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain C
222–458（237 aa）
Fragment：UNP residues 222-458
|
Not recorded | 9S6 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.1M BIS-TRIS pH6.5, 16 %(w/v) PEG 10K, 3% MetOH
|
Resolution 2.90 Å R-free 0.263 |
| 6I61 Crystal structure of human ERRg LBD in complex with bisphenol-B Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | H3W bisphenol-B × 2 EDO 1,2-ETHANEDIOL × 2 GOL GLYCEROL × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate
100 mM Tris
23-26% PEG 8000
|
Resolution 1.65 Å R-free 0.219 |
| 6I62 Crystal structure of human ERRg LBD in complex with HPTE Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | 27N 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0-100 mM Sodium Acetate
100 mM Tris
23-26% PEG 8000
|
Resolution 1.65 Å R-free 0.200 |
| 6I63 Crystal structure of human ERRg LBD in complex with bisphenol-A Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | 2OH 4,4'-PROPANE-2,2-DIYLDIPHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate
100 mM Tris
23-26% PEG8000
|
Resolution 2.23 Å R-free 0.206 |
| 6I64 Crystal structure of human ERRg LBD in complex with bisphenol-E Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | H48 4-[1-(4-hydroxyphenyl)ethyl]phenol × 2 GOL GLYCEROL × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium Acetate
100 mM Tris
23-26% PEG8000
|
Resolution 1.91 Å R-free 0.237 |
| 6I65 Crystal structure of human ERRg LBD in complex with 4-iso-propylphenol Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | H3Z 4-propan-2-ylphenol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetat
100 mM Tris
23-26% PEG8000
|
Resolution 1.50 Å R-free 0.198 |
| 6I66 Crystal structure of human ERRg LBD in complex with 4-sec-butylphenol Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | H4Q 4-[(2~{R})-butan-2-yl]phenol × 2 GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetate
100 mM Tris
23-26% PEG8000
|
Resolution 1.60 Å R-free 0.207 |
| 6I67 Crystal structure of human ERRg LBD in complex with tetrahydro-2-naphtol Deposited 2018-11-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
222–458（237 aa）
|
Not recorded | H42 5,6,7,8-tetrahydronaphthalen-2-ol × 2 GOL GLYCEROL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；293 K；0-100 mM Sodium acetate
100 mM Tris
23-26% PEG8000
|
Resolution 1.75 Å R-free 0.208 |
| 6K3N Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with BPA-monoF Deposited 2019-05-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
232–458（227 aa）
|
Not recorded | CW6 2-fluoranyl-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.05M HEPES, 0.75M sodium citrate, 5% glycerol, pH 7.5,
|
Resolution 1.97 Å R-free 0.253 |
| 6KNR Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 Deposited 2019-08-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
222–458（237 aa）
Fragment：ligand-binding domain
|
Not recorded | DL9 (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.28M K Na Tartrate
|
Resolution 2.80 Å R-free 0.226 |
| 6KNR Crystal structure of Estrogen-related receptor gamma ligand-binding domain with DN200699 Deposited 2019-08-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
222–458（237 aa）
Fragment：ligand-binding domain
|
Not recorded | DL9 (E)-4-(1-(4-(1-cyclopropylpiperidin-4-yl)phenyl)-5-hydroxy-2-phenylpent-1-en-1-yl)phenol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；0.28M K Na Tartrate
|
Resolution 2.80 Å R-free 0.226 |
| 8B4Q Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 5 Deposited 2022-09-20 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
174–182（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 OYI 3-fluoranyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
|
Resolution 1.40 Å R-free 0.175 |
| 8BJG Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 8 Deposited 2022-11-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
174–182（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 8 CL CHLORIDE ION × 2 QL0 3-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
|
Resolution 1.40 Å R-free 0.175 |
| 8BJN Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 6 Deposited 2022-11-04 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
174–182（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 QL9 3-bromanyl-4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
|
Resolution 1.40 Å R-free 0.175 |
| 8BM5 Ternary structure of 14-3-3s, ERRg phosphopeptide and dual-reactive compound 7 Deposited 2022-11-10 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain B
174–182（9 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | MG MAGNESIUM ION × 6 CL CHLORIDE ION × 2 QQ0 4-methanoyl-~{N}-methyl-~{N}-(2-sulfanylethyl)benzenesulfonamide × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；0.095 M Hepes pH 7.1, 0.19 M CaCl2, 25% PEG400, 5% glycerol
|
Resolution 1.40 Å R-free 0.186 |
| 8IFO Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter Deposited 2023-02-19 | Assembly 1 Protein–DNA Homooligomer；Protein × 2 PDB declaration: tetrameric（4） Consistent with all polymers |
Chain A
123–219（97 aa）
Chain B
123–219（97 aa）
|
Not recorded | ZN ZINC ION × 5 MLI MALONATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.1 M Sodium malonate pH 6.0, 12% w/v Polyethylene glycol 3,350
|
Resolution 2.20 Å R-free 0.260 |
| 8IFO Crystal structure of estrogen related receptor-gamma DNA binding domain complexed with Pla2g12b promoter Deposited 2023-02-19 | Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: trimeric（3） Consistent with all polymers |
Chain F
123–219（97 aa）
|
Not recorded | ZN ZINC ION × 2 MLI MALONATE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.1 M Sodium malonate pH 6.0, 12% w/v Polyethylene glycol 3,350
|
Resolution 2.20 Å R-free 0.260 |
| 9KNC Crystal structure of human ERRg LBD in complex with 6-nitroindole Deposited 2024-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | A1EF8 6-nitro-1~{H}-indole × 2 PGR R-1,2-PROPANEDIOL × 12 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
|
Resolution 1.90 Å R-free 0.232 |
| 9KND Crystal structure of human ERRg LBD in complex with indole Deposited 2024-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | IND INDOLE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
|
Resolution 1.52 Å R-free 0.212 |
| 9KNE Crystal structure of human ERRg LBD in complex with 5-nitroindole Deposited 2024-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | 2HU 5-nitro-1H-indole × 2 PGR R-1,2-PROPANEDIOL × 8 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME 0.1M Tris 8.0 0.2M lithium sulfate
|
Resolution 1.80 Å R-free 0.224 |
| 9KNF Crystal structure of human ERRg LBD in complex with 4028691 Deposited 2024-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | A1EGB 5-chloranyl-2~{H}-indazole × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；1.0 M K/Na tartrate, 0.1 M Tris pH 7.0, 0.2 M Li2SO4
|
Resolution 1.62 Å R-free 0.228 |
| 9KNG Crystal structure of human ERRg LBD in complex with 4034496 Deposited 2024-11-18 | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count |
Chain A
229–458（230 aa）
|
Not recorded | A1EGD 6-methyl-1,3-benzothiazole-2,4-diamine × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；30%(w/v) PEG 5000 MME, 0.1M Tris 8.0, 0.2M lithium sulfate
|
Resolution 1.50 Å R-free 0.234 |