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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q12959 New Search
12PDB entries
18Biological assembly
36chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
1PDR CRYSTAL STRUCTURE OF THE THIRD PDZ DOMAIN FROM THE HUMAN HOMOLOG OF DISCS LARGE PROTEIN Deposited 1996-07-26 Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 457–555（99 aa） Fragment：PDZ3 DOMAIN, DHR3 DOMAIN
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.80 Å R-free 0.271
2M3M Solution structure of a complex consisting of hDlg/SAP-97 residues 318-406 and HPV51 oncoprotein E6 residues 141-151 Deposited 2013-01-22 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 318–406（89 aa） Fragment：hDlgPDZ2, UNP residues 318-406
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 20；Pressure ambient
NMR sample composition 0.8 mM [U-100% 13C; U-100% 15N] hDlgPDZ2, 2.0 mM E6CT11, 20 mM sodium phosphate, 4 mM TCEP, 0.05 w/v sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
NMR sample composition 0.8 mM [U-100% 13C; U-100% 15N] hDlgPDZ2, 2.0 mM E6CT11, 20 mM sodium phosphate, 4 mM TCEP, 0.05 w/v sodium azide, 100% D2O | 100% D2O
NMR sample composition 3.12 mM hDlgPDZ2, 1.25 mM [U-100% 13C; U-100% 15N] E6CT11, 20 mM sodium phosphate, 4 mM TCEP, 0.05 w/v sodium azide, 100% D2O | 100% D2O
NMR sample composition 3.12 mM hDlgPDZ2, 1.25 mM [U-100% 13C; U-100% 15N] E6CT11, 20 mM sodium phosphate, 4 mM TCEP, 0.05 w/v sodium azide, 90% H2O/10% D2O | 90% H2O/10% D2O
Resolution not provided
2OQS Structure of the hDLG/SAP97 PDZ2 in complex with HPV-18 papillomavirus E6 peptide Deposited 2007-02-01 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 318–405（88 aa） Fragment：second PDZ domain, residues 318-406
Not recorded No recorded non-water small molecule SOLUTION NMR
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR measurement conditions pH 6.5；293 K；Ionic strength (raw mmCIF value) 28.2 mM；Pressure ambient
NMR sample composition 2mM hDLG/SAP97 PDZ2 domain, 3mM HPV-18 E6 peptide, 4 mM TCEP, 20 uM DSS, 20mM phosphate buffer, pH 6.5, 99.5% D2O | 99.5% D2O
NMR sample composition 2mM hDLG/SAP97 PDZ2 domain U-15N, 3mM HPV-18 E6 peptide, 4 mM TCEP, 20 uM DSS, 20mM phosphate buffer, pH 6.5, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM hDLG/SAP97 PDZ2 domain U-15N, 13C, 3 mM HPV-18 E6 peptide, 4 mM TCEP, 20 uM DSS, 20 mM phosphate buffer, pH 6.5, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM hDLG/SAP97 PDZ2 domain, U-15N, U-10%13C, 3 mM HPV-18 E6 peptide, 4 mM TCEP, 20 uM DSS, 20mM phosphate buffer, pH 6.5 | 90% H2O/10% D2O
NMR sample composition 2 mM hDLG/SAP97 PDZ2 domain, U-15N, 3 mM HPV-18 E6 peptide, 5% C8E5, C8E5/n-octanol 0.87, 4 mM TCEP, 20 uM DSS, 20mM phosphate buffer, pH 6.5, 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR sample composition 2 mM hDLG/SAP97 PDZ2 domain, U-15N, 3 mM HPV-18 E6 peptide, 10 mg/ml pf1 phage, 4 mM TCEP, 20 uM DSS, 20mM phosphate buffer, pH 6.5,90% H2O, 10% D2O | 90% H2O/10% D2O
Resolution not provided
2X7Z Crystal Structure of the SAP97 PDZ2 I342W C378A mutant protein domain Deposited 2010-03-04 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 260–356（97 aa） Fragment：PDZ2 DOMAIN, RESIDUES 260-356
Mutation：YES NH4 AMMONIUM ION × 2 IMD IMIDAZOLE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.4；VAPOR DIFFUSION, 100MM TRIS-HCL PH 8.4, 2.4M AMMONIUM SULPHATE
Resolution 2.00 Å R-free 0.232
3LRA Structural Basis for Assembling a Human Tripartite Complex Dlg1-MPP7-Mals3 Deposited 2010-02-10 Assembly 1 Insufficient information Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 2–65（64 aa） Fragment：L27 domain, L27 1/2 domain
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；10% PEG 8000, 0.2M MgCl2, 0.1M Guanidine HCl, 0.1M Tris-HCl, pH7.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.95 Å R-free 0.284
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain C 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain D 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain E 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL7 Crystal structure of hDLG1-PDZ1 complexed with APC Deposited 2011-04-19 Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain F 220–317（98 aa） Fragment：UNP RESIDUES 220-317
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.30 Å R-free 0.231
3RL8 Crystal structure of hDLG1-PDZ2 complexed with APC Deposited 2011-04-19 Assembly 1 Protein heterocomplex Heteromer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count
Chain A 315–410（96 aa） Fragment：UNP RESIDUES 315-410
Chain B 315–410（96 aa） Fragment：UNP RESIDUES 315-410
Chain C 315–410（96 aa） Fragment：UNP RESIDUES 315-410
Chain D 315–410（96 aa） Fragment：UNP RESIDUES 315-410
Chain E 315–410（96 aa） Fragment：UNP RESIDUES 315-410
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；287 K；0.8M Na2HPO4, 0.9M KH2PO4, pH 7.5, vapor diffusion, hanging drop, temperature 287K
Resolution 2.20 Å R-free 0.245
4AMH Influence of circular permutation on the folding pathway of a PDZ domain Deposited 2012-03-10 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 327–405（79 aa） Fragment：PDZ2 DOMAIN
Chain A 315–326（12 aa） Fragment：PDZ2 DOMAIN
Chain B 327–405（79 aa） Fragment：PDZ2 DOMAIN
Chain B 315–326（12 aa） Fragment：PDZ2 DOMAIN
Mutation：YES Mutation：YES Mutation：YES Mutation：YES TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；SITTING DROP VAPOR DIFFUSION, 0.1 M MES PH 6.0, 2.4 M AMMONIUM SULFATE
Resolution 2.30 Å R-free 0.268
4G69 Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex Deposited 2012-07-18 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 310–407（98 aa） Fragment：PDZ2, UNP residues 310-407
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.25；300 K；Protein solution: 1.4 mM Dlg1 PDZ2, 1.7 mM APC, 100 mM NaCl, 25 mM Tris pH 7.0, 0.1% B-ME Well: 200 mM sodium acetate, 100 mM sodium cacodylate pH 6.25, 28% PEG 8000 Drop = 1:1 protein:well solution , VAPOR DIFFUSION, HANGING DROP, temperature 300K
Resolution 2.00 Å R-free 0.183
7PC3 The second PDZ domain of DLG1 complexed with the PDZ-binding motif of HTLV1-TAX1 Deposited 2021-08-03 Assembly 1 Insufficient information Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 314–413（100 aa）
Not recorded CA CALCIUM ION × 4 GOL GLYCEROL × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M Lithium sulfate, 0.1 M bis-Tris pH 5.5, 25% w/v PEG 3350
Resolution 1.95 Å R-free 0.201
8CN1 hDLG1-PDZ1 in complex with a TAX1 peptide from HTLV-1 Deposited 2023-02-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 24 PDB declaration: 24-meric（24） Consistent with protein count
Chain A 219–311（93 aa）
Chain B 219–311（93 aa）
Chain C 219–311（93 aa）
Chain D 219–311（93 aa）
Chain E 219–311（93 aa）
Chain F 219–311（93 aa）
Chain G 219–311（93 aa）
Chain H 219–311（93 aa）
Chain I 219–311（93 aa）
Chain J 219–311（93 aa）
Chain K 219–311（93 aa）
Chain L 219–311（93 aa）
Not recorded SO4 SULFATE ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Bis-Tris pH 5.5, 0.18 M (NH4)2SO4, 24% PEG3350
Resolution 2.09 Å R-free 0.246
8CN3 hDLG1-PDZ2 in complex with a TAX1 peptide from HTLV-1 Deposited 2023-02-21 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 260–371（112 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Bis-Tris pH 5.5, 0.075M (NH4)2SO4, 24% PEG3350
Resolution 2.71 Å R-free 0.259
8CN3 hDLG1-PDZ2 in complex with a TAX1 peptide from HTLV-1 Deposited 2023-02-21 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 195–306（112 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.1 M Bis-Tris pH 5.5, 0.075M (NH4)2SO4, 24% PEG3350
Resolution 2.71 Å R-free 0.259

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.