Current Protein Identity：Q15562
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 3L15 Human Tead2 transcriptional factor Deposited 2009-12-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
Fragment：C-terminal residues 217-447
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.1 M Tris, 2.5 M Sodium Formate, 100 mM NaCl, 2 mM MgCl2, 1 mM TCEP, 5% (w/v) Glycerol;, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.244 |
| 3L15 Human Tead2 transcriptional factor Deposited 2009-12-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
Fragment：C-terminal residues 217-447
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | GOL GLYCEROL × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8.4；293 K；0.1 M Tris, 2.5 M Sodium Formate, 100 mM NaCl, 2 mM MgCl2, 1 mM TCEP, 5% (w/v) Glycerol;, pH 8.4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.244 |
| 5DQ8 Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid Deposited 2015-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | FLF 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate
|
Resolution 2.31 Å R-free 0.232 |
| 5DQ8 Crystal structure of human transcription factor TEAD2 in complex with flufenamic acid Deposited 2015-09-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | FLF 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate
|
Resolution 2.31 Å R-free 0.232 |
| 5DQE Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid Deposited 2015-09-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | 5E4 2-[(3-bromophenyl)amino]benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2 and 2.4 M sodium formate.
|
Resolution 2.18 Å R-free 0.227 |
| 5DQE Crystal structure of human transcription factor TEAD2 in complex with bromo-fenamic acid Deposited 2015-09-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | 5E4 2-[(3-bromophenyl)amino]benzoic acid × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M HEPES pH 7.2 and 2.4 M sodium formate.
|
Resolution 2.18 Å R-free 0.227 |
| 5EMV Crystal structure of the palmitoylated human TEAD2 transcription factor Deposited 2015-11-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
218–446（229 aa）
Fragment：YAP binding domain, unp residues 219-435
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.3；292 K；1.7-2.1 M Sodium Formate
|
Resolution 2.00 Å R-free 0.231 |
| 5EMV Crystal structure of the palmitoylated human TEAD2 transcription factor Deposited 2015-11-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
218–446（229 aa）
Fragment：YAP binding domain, unp residues 219-435
|
Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.3；292 K；1.7-2.1 M Sodium Formate
|
Resolution 2.00 Å R-free 0.231 |
| 5HGU Crystal structure of human transcription factor TEAD2 in complex with palmitate Deposited 2016-01-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | PLM PALMITIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate
|
Resolution 2.05 Å R-free 0.222 |
| 5HGU Crystal structure of human transcription factor TEAD2 in complex with palmitate Deposited 2016-01-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
Fragment：residues 217-447
|
Not recorded | PLM PALMITIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 7.2；293 K；0.1 M HEPES pH 7.2, 2.4 M sodium formate
|
Resolution 2.05 Å R-free 0.222 |
| 6CDY Crystal structure of TEAD complexed with its inhibitor Deposited 2018-02-09 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | EY1 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2,
2.4 M sodium formate.
|
Resolution 2.32 Å R-free 0.255 |
| 6CDY Crystal structure of TEAD complexed with its inhibitor Deposited 2018-02-09 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | EY1 2-[(4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]phenyl}acetamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2,
2.4 M sodium formate.
|
Resolution 2.32 Å R-free 0.255 |
| 6E5G Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2018-07-20 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
220–450（231 aa）
|
Not recorded | HUY 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；2.4-2.8 M sodium formate, HEPES, pH 7.2- 7.4
|
Resolution 2.43 Å R-free 0.268 |
| 6E5G Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2018-07-20 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
220–450（231 aa）
|
Not recorded | HUY 1-(2-{[3-(trifluoromethyl)phenyl]amino}phenyl)ethan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；2.4-2.8 M sodium formate, HEPES, pH 7.2- 7.4
|
Resolution 2.43 Å R-free 0.268 |
| 6S60 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.00 Å R-free 0.228 |
| 6S60 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 KX8 4-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]butanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.00 Å R-free 0.228 |
| 6S64 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.22 Å R-free 0.259 |
| 6S64 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | PLM PALMITIC ACID × 1 KXE 3-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]propanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.22 Å R-free 0.259 |
| 6S66 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.20 Å R-free 0.262 |
| 6S66 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 KWW 1-(2-azanylethyl)-3-(3,4-dichlorophenyl)-~{N}-(phenylmethyl)pyrazole-4-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.20 Å R-free 0.262 |
| 6S69 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.15 Å R-free 0.255 |
| 6S69 Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-02 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 KX5 3-[3-(3,4-dichlorophenyl)-4-(2-phenylethylcarbamoyl)pyrazol-1-yl]propanoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.15 Å R-free 0.255 |
| 6S6J Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor Deposited 2019-07-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–447（231 aa）
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 2 KXH ethyl 1-(4-azanylbutyl)-3-(3,4-dichlorophenyl)pyrazole-4-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.10 Å R-free 0.231 |
| 6UYB Crystal structure of TEAD2 bound to Compound 1 Deposited 2019-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
221–451（231 aa）
|
Not recorded | GOL GLYCEROL × 1 QSJ (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5
20% PEG 3350
|
Resolution 1.54 Å R-free 0.232 |
| 6UYB Crystal structure of TEAD2 bound to Compound 1 Deposited 2019-11-12 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
221–451（231 aa）
|
Not recorded | QSJ (3R,4R)-1-{3-[(E)-2-(4-chlorophenyl)ethenyl]-4-methoxy-5-methylphenyl}-3,4-dihydroxypyrrolidin-2-one × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5
20% PEG 3350
|
Resolution 1.54 Å R-free 0.232 |
| 6UYC Crystal structure of TEAD2 bound to Compound 2 Deposited 2019-11-12 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
221–451（231 aa）
|
Not recorded | QLV N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5
20% PEG 3350
|
Resolution 1.66 Å R-free 0.216 |
| 6UYC Crystal structure of TEAD2 bound to Compound 2 Deposited 2019-11-12 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
221–451（231 aa）
|
Not recorded | QLV N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate pH 6.5
20% PEG 3350
|
Resolution 1.66 Å R-free 0.216 |
| 6VAH Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative Deposited 2019-12-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | QZ1 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；3.5M Na Formate, and 0.1M Bis-Tris Propane pH7.0
|
Resolution 2.11 Å R-free 0.242 |
| 6VAH Crystal structure of human TEAD2 transcription factor in complex with Flufenamic acid derivative Deposited 2019-12-17 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | QZ1 2-fluoro-6-[(3-hexylphenyl)amino]benzoic acid × 1 UNX UNKNOWN LIGAND × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；3.5M Na Formate, and 0.1M Bis-Tris Propane pH7.0
|
Resolution 2.11 Å R-free 0.242 |
| 7OYJ Crystal structure of hTEAD2 in complex with fragment at the interface 2 Deposited 2021-06-24 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | PLM PALMITIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 1.91 Å R-free 0.222 |
| 7OYJ Crystal structure of hTEAD2 in complex with fragment at the interface 2 Deposited 2021-06-24 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | PLM PALMITIC ACID × 1 3DI 3-(1~{H}-pyrazol-5-yl)aniline × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 1.91 Å R-free 0.222 |
| 7T2J Crystal Structure of TEAD2 in a covalent complex with TED-642 Deposited 2021-12-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | E8Y 4-[3-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.70 Å R-free 0.279 |
| 7T2J Crystal Structure of TEAD2 in a covalent complex with TED-642 Deposited 2021-12-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | E8Y 4-[3-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.70 Å R-free 0.279 |
| 7T2K Crystal Structure of TEAD2 in a covalent complex with TED-661 Deposited 2021-12-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | ED0 4-[2-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 M - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.34 Å R-free 0.286 |
| 7T2K Crystal Structure of TEAD2 in a covalent complex with TED-661 Deposited 2021-12-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | ED0 4-[2-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 M - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.34 Å R-free 0.286 |
| 7T2L Crystal Structure of TEAD2 in a covalent complex with TED-662 Deposited 2021-12-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES, pH 7.2-7.4
|
Resolution 2.15 Å R-free 0.257 |
| 7T2L Crystal Structure of TEAD2 in a covalent complex with TED-662 Deposited 2021-12-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | EFI (3aR,4R,7aS)-4-[3-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES, pH 7.2-7.4
|
Resolution 2.15 Å R-free 0.257 |
| 7T2M Crystal Structure of TEAD2 in a covalent complex with TED-664 Deposited 2021-12-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | EGK (3aR,4R,7aS)-4-[2-(trifluoromethyl)anilino]octahydro-2H-isoindole-2-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.81 Å R-free 0.279 |
| 7T2M Crystal Structure of TEAD2 in a covalent complex with TED-664 Deposited 2021-12-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.81 Å R-free 0.279 |
| 7TYP TEAD2 bound to GNE-7883 Deposited 2022-02-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 KUR (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.60 Å R-free 0.216 |
| 7TYP TEAD2 bound to GNE-7883 Deposited 2022-02-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | KUR (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.60 Å R-free 0.216 |
| 7TYQ TEAD2 bound to Compound 1 Deposited 2022-02-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | KUI ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.88 Å R-free 0.247 |
| 7TYQ TEAD2 bound to Compound 1 Deposited 2022-02-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | KUI ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.88 Å R-free 0.247 |
| 7TYU TEAD2 bound to Compound 2 Deposited 2022-02-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | KTF (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.78 Å R-free 0.230 |
| 7TYU TEAD2 bound to Compound 2 Deposited 2022-02-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | KTF (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M Na/K Tartrate, 0.1 M Bis Tris pH 6.5, 35% PEG 3350
|
Resolution 1.78 Å R-free 0.230 |
| 8CUH Crystal structure of human TEAD2 complexed with its inhibitor TM2. Deposited 2022-05-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | P0I 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2,
2.4 M sodium formate.
|
Resolution 2.40 Å R-free 0.235 |
| 8CUH Crystal structure of human TEAD2 complexed with its inhibitor TM2. Deposited 2022-05-17 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | P0I 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.2；293 K；0.1 M Hepes, pH 7.2,
2.4 M sodium formate.
|
Resolution 2.40 Å R-free 0.235 |
| 8E1O Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder Deposited 2022-08-10 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Mutation：UNP residues 217-447 | TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 Y2S 5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate, pH 6.5, 20% PEG3350
|
Resolution 2.25 Å R-free 0.247 |
| 8E1O Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder Deposited 2022-08-10 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Mutation：UNP residues 217-447 | Y2S 5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；292 K；200 mM potassium/sodium tartrate, pH 6.5, 20% PEG3350
|
Resolution 2.25 Å R-free 0.247 |
| 8P29 TEAD2 in complex with an inhibitor Deposited 2023-05-15 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.06 Å R-free 0.240 |
| 8P29 TEAD2 in complex with an inhibitor Deposited 2023-05-15 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | GOL GLYCEROL × 1 WJC 5-methyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.06 Å R-free 0.240 |
| 8POJ TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.45 Å R-free 0.268 |
| 8POJ TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | ZUL 4-fluoranyl-2-[(3-phenylphenyl)amino]benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.45 Å R-free 0.268 |
| 8POM TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | ZUP 2-[[3-(2-phenylethoxy)phenyl]amino]pyridine-3-carboxylic acid × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 1.95 Å R-free 0.248 |
| 8POM TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | ZUP 2-[[3-(2-phenylethoxy)phenyl]amino]pyridine-3-carboxylic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 1.95 Å R-free 0.248 |
| 8PON TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.20 Å R-free 0.254 |
| 8PON TEAD2 in complex with an inhibitor Deposited 2023-07-05 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | ZUT 4-fluoranyl-2-[(3-phenylmethoxyphenyl)amino]benzoic acid × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.20 Å R-free 0.254 |
| 8PUX TEAD2 with a covalent inhibitor Deposited 2023-07-17 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.05 Å R-free 0.261 |
| 8PUX TEAD2 with a covalent inhibitor Deposited 2023-07-17 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | B3F ~{N}-[2-[(3-pentoxyphenyl)amino]phenyl]propanamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.05 Å R-free 0.261 |
| 8PUY TEAD2 with a covalent inhibitor Deposited 2023-07-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–447（231 aa）
Chain B
217–447（231 aa）
|
Not recorded | F3Y ~{N}-[3-[(3-pentoxyphenyl)amino]phenyl]propanamide × 1 MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.20 Å R-free 0.252 |
| 8RXL TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
216–447（232 aa）
|
Not recorded | A1H3Z 4-(5-phenylmethoxy-1~{H}-indol-3-yl)butan-2-one × 1 GOL GLYCEROL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2.8M sodium formate
|
Resolution 2.29 Å R-free 0.271 |
| 8RXL TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
216–447（232 aa）
|
Not recorded | A1H3Z 4-(5-phenylmethoxy-1~{H}-indol-3-yl)butan-2-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；2.8M sodium formate
|
Resolution 2.29 Å R-free 0.271 |
| 8RXP TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | A1H3Y 2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethanol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.49 Å R-free 0.274 |
| 8RXP TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | A1H3Y 2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethanol × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；2.8M sodium formate
|
Resolution 2.49 Å R-free 0.274 |
| 8RXQ TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | A1H3X ethyl (~{E})-3-(5-phenylmethoxy-1~{H}-indol-3-yl)prop-2-enoate × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.63 Å R-free 0.269 |
| 8RXQ TEAD2 with an inhibitor Deposited 2024-02-07 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.63 Å R-free 0.269 |
| 8RXV TEAD2 with an inhibitor Deposited 2024-02-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | A1H3W ~{N}-[2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethyl]methanesulfonamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.05 Å R-free 0.297 |
| 8RXV TEAD2 with an inhibitor Deposited 2024-02-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | A1H3W ~{N}-[2-(5-phenylmethoxy-1~{H}-indol-3-yl)ethyl]methanesulfonamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.05 Å R-free 0.297 |
| 8RYC TEAD2 with an inhibitor Deposited 2024-02-08 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | A1H32 5-phenylmethoxy-1~{H}-indole × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.09 Å R-free 0.249 |
| 8RYC TEAD2 with an inhibitor Deposited 2024-02-08 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | MYR MYRISTIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；288 K；2.8M sodium formate
|
Resolution 2.09 Å R-free 0.249 |
| 8YGQ Crystal structure of Human TEAD2 in complex with Cobimetinib Deposited 2024-02-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
221–446（226 aa）
Chain B
221–446（226 aa）
|
Not recorded | PLM PALMITIC ACID × 1 EUI [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；293 K；0.1 M HEPS pH 7.0, 2.6 M sodium formate
|
Resolution 2.71 Å R-free 0.257 |
| 9NEO TEAD2 YAP binding domain (YBD) Deposited 2025-02-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
217–447（231 aa）
Fragment：UNP Residues 217-447
Chain B
217–447（231 aa）
Fragment：UNP Residues 217-447
|
Not recorded | A1BXX (3R)-3-ethenyl-3-(5-{3-[4-(trifluoromethyl)anilino]pyridin-2-yl}-1,3,4-oxadiazol-2-yl)pyrrolidin-2-one × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293.15 K；3.1M Na Formate, 100mM HEPES pH 7.5
|
Resolution 3.13 Å R-free 0.316 |
| 9Q1M Crystal structure of human TEAD2 Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | IU8 1-{4-[3-(trifluoromethyl)anilino]-2H-isoindol-2-yl}propan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.60 Å R-free 0.261 |
| 9Q1M Crystal structure of human TEAD2 Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | IU8 1-{4-[3-(trifluoromethyl)anilino]-2H-isoindol-2-yl}propan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8 - 2.4 M
Hepes pH 7.2 - 7.4
|
Resolution 2.60 Å R-free 0.261 |
| 9Q1N Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | EI2 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.13 Å R-free 0.248 |
| 9Q1N Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | EI2 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.13 Å R-free 0.248 |
| 9Q1O Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | EI6 1-{(3aS,4R,7aR)-4-[4-(trifluoromethyl)anilino]octahydro-2H-isoindol-2-yl}propan-1-one × 1 FMT FORMIC ACID × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.26 Å R-free 0.266 |
| 9Q1O Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Deposited 2025-08-14 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | EI6 1-{(3aS,4R,7aR)-4-[4-(trifluoromethyl)anilino]octahydro-2H-isoindol-2-yl}propan-1-one × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Sodium Formate 1.8M - 2.4M
HEPES pH 7.2 - 7.4
|
Resolution 2.26 Å R-free 0.266 |
| 9YK2 Crystal structure of TEAD2 with non-covalent aryl ether inhibitor. Deposited 2025-10-06 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
217–447（231 aa）
|
Not recorded | A1CXJ (3P)-N-methyl-3-(1-methyl-1H-pyrazol-4-yl)-4-[4-(trifluoromethyl)phenoxy]benzene-1-sulfonamide × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；21% PEG 3350, 0.15 M NaSO4, 0.1 M Bis-Tris propane (pH 6.5)
|
Resolution 2.16 Å R-free 0.288 |
| 9YK2 Crystal structure of TEAD2 with non-covalent aryl ether inhibitor. Deposited 2025-10-06 | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain B
217–447（231 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；277 K；21% PEG 3350, 0.15 M NaSO4, 0.1 M Bis-Tris propane (pH 6.5)
|
Resolution 2.16 Å R-free 0.288 |