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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q495A1 New Search
12PDB entries
25Biological assembly
29chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3Q0H Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) Deposited 2010-12-15 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 22–137（116 aa） Fragment：Ig-like V-type domain residues 22-137
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1.3M Ammonium Sulfate, 0.1M MES pH 6.0, Vapor diffusion, Sitting drop, temperature 298K
Resolution 1.70 Å R-free 0.237
3Q0H Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) Deposited 2010-12-15 Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain B 22–137（116 aa） Fragment：Ig-like V-type domain residues 22-137
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；298 K；1.3M Ammonium Sulfate, 0.1M MES pH 6.0, Vapor diffusion, Sitting drop, temperature 298K
Resolution 1.70 Å R-free 0.237
3RQ3 Structure of T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in hexagonal crystal form Deposited 2011-04-27 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 22–137（116 aa） Fragment：UNP residues 22-137
Chain B 22–137（116 aa） Fragment：UNP residues 22-137
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.5；298 K；1.0M Ammonium Sulfate, 0.1M BIS-TRIS pH 5.5, 1% PEG3350, Vapor diffusion, Sitting drop, temperature 298K
Resolution 2.70 Å R-free 0.253
3UCR Crystal structure of the immunoreceptor TIGIT IgV domain Deposited 2011-10-27 Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 23–128（106 aa） Fragment：UNP residues 23-128
Chain C 23–128（106 aa） Fragment：UNP residues 23-128
Not recorded CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.5 M (NH4)2SO4 and 0.1M HEPES pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.63 Å R-free 0.274
3UCR Crystal structure of the immunoreceptor TIGIT IgV domain Deposited 2011-10-27 Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 23–128（106 aa） Fragment：UNP residues 23-128
Chain D 23–128（106 aa） Fragment：UNP residues 23-128
Not recorded CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；1.5 M (NH4)2SO4 and 0.1M HEPES pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.63 Å R-free 0.274
3UDW Crystal structure of the immunoreceptor TIGIT in complex with Poliovirus receptor (PVR/CD155/necl-5) D1 domain Deposited 2011-10-28 Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric（4） Consistent with protein count
Chain A 20–128（109 aa） Fragment：TIGIT, UNP residues 20-128
Chain B 20–128（109 aa） Fragment：TIGIT, UNP residues 20-128
Not recorded NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；0.1 M Ammonium acetate 0.1 M Bis-Tris pH 5.5 17% PEG 10000, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.90 Å R-free 0.287
5V52 Structure of TIGIT bound to nectin-2 (CD112) Deposited 2017-03-13 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 22–128（107 aa）
Not recorded GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；1.3 M Lithium Sulfate 0.1M Tris ph7
Resolution 3.10 Å R-free 0.236
5V52 Structure of TIGIT bound to nectin-2 (CD112) Deposited 2017-03-13 Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain B 22–128（107 aa）
Not recorded SO4 SULFATE ION × 1 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；1.3 M Lithium Sulfate 0.1M Tris ph7
Resolution 3.10 Å R-free 0.236
7VYT Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 Deposited 2021-11-15 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 23–129（107 aa）
Not recorded FLC CITRATE ANION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；200mM ammonium citrate, 20% (v/v) polyethylene glycol 3350
Resolution 1.53 Å R-free 0.219
7VYT Crystal structure of human TIGIT(23-129) in complex with the scFv fragment of anti-TIGIT antibody MG1131 Deposited 2021-11-15 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain T 23–129（107 aa）
Not recorded FLC CITRATE ANION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；200mM ammonium citrate, 20% (v/v) polyethylene glycol 3350
Resolution 1.53 Å R-free 0.219
8JEL Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Deposited 2023-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain J 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M citric acid pH 4.6, 1 M lithium chloride, 7% PEG6000
Resolution 2.45 Å R-free 0.249
8JEL Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Deposited 2023-05-16 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M citric acid pH 4.6, 1 M lithium chloride, 7% PEG6000
Resolution 2.45 Å R-free 0.249
8JEL Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Deposited 2023-05-16 Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain H 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M citric acid pH 4.6, 1 M lithium chloride, 7% PEG6000
Resolution 2.45 Å R-free 0.249
8JEL Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I Deposited 2023-05-16 Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain L 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M citric acid pH 4.6, 1 M lithium chloride, 7% PEG6000
Resolution 2.45 Å R-free 0.249
8JEN Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Deposited 2023-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain I 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate tribasic dihydrate pH 5.2, 17% PEG 20000
Resolution 2.71 Å R-free 0.289
8JEN Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Deposited 2023-05-16 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain J 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate tribasic dihydrate pH 5.2, 17% PEG 20000
Resolution 2.71 Å R-free 0.289
8JEN Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Deposited 2023-05-16 Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain M 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate tribasic dihydrate pH 5.2, 17% PEG 20000
Resolution 2.71 Å R-free 0.289
8JEN Crystal structure of TIGIT in complexed with Ociperlimab, crystal form II Deposited 2023-05-16 Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain P 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium citrate tribasic dihydrate pH 5.2, 17% PEG 20000
Resolution 2.71 Å R-free 0.289
8JEO Crystal structure of TIGIT in complexed with Tiragolumab Deposited 2023-05-16 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain A 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M ammonium citrate tribasic pH 7.4, 14% PEG 3350
Resolution 2.06 Å R-free 0.205
8JEO Crystal structure of TIGIT in complexed with Tiragolumab Deposited 2023-05-16 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain D 22–128（107 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M ammonium citrate tribasic pH 7.4, 14% PEG 3350
Resolution 2.06 Å R-free 0.205
8SZY Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Deposited 2023-05-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain T 23–128（106 aa）
Mutation：C69S NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；300 K；0.2 M sodium phosphate monobasic monohydrate, 20% w/v Polyethylene glycol 1,000
Resolution 2.31 Å R-free 0.269
8SZY Crystal Structure of Heterotrimeric Anti-TIGIT Fabs in complex with human TIGIT Deposited 2023-05-30 Assembly 2 Protein heterocomplex Heteromer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count
Chain U 23–128（106 aa）
Mutation：C69S NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；300 K；0.2 M sodium phosphate monobasic monohydrate, 20% w/v Polyethylene glycol 1,000
Resolution 2.31 Å R-free 0.269
8VTD Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Deposited 2024-01-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain C 22–137（116 aa）
Not recorded GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；300 K；16% w/v PEG 20K
Resolution 1.23 Å R-free 0.204
8VTE Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Deposited 2024-01-26 Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain E 22–137（116 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；300 K；0.02M D-Glucose; 0.02M D-Mannose; 0.02M D-Galactose; 0.02M L-Fucose; 0.02M D-Xylose; 0.02M N-Acetyl-D-Glucosamine; 0.1M Imidazole, 0.1M MES; 20%v/v Glycerol; 10% PEG4K
Resolution 2.29 Å R-free 0.268
8VTE Co-structure of the Fab of the anti-TIGIT Vibostolimab antibody with its antigen Deposited 2024-01-26 Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric（3） Consistent with protein count
Chain F 22–137（116 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；300 K；0.02M D-Glucose; 0.02M D-Mannose; 0.02M D-Galactose; 0.02M L-Fucose; 0.02M D-Xylose; 0.02M N-Acetyl-D-Glucosamine; 0.1M Imidazole, 0.1M MES; 20%v/v Glycerol; 10% PEG4K
Resolution 2.29 Å R-free 0.268

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.