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Protein Structures and Oligomeric States

Enter a protein name, UniProt accession or PDB ID. Name searches ask you to confirm the protein identity before related structures are queried.

Current Protein Identity：Q76NL8 New Search
15PDB entries
15Biological assembly
15chain/assembly records
Main Difference Dimensions in This Set
Different construct Different mutation/modification Different assembly state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics

Difference tags compare only the current result set; every original PDB and assembly record remains separate.

Related-Structure Differences

Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.

PDB Entry Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Experimental Method Experimental Conditions Structure Quality
3S5H Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum Deposited 2011-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1193（1193 aa）
Not recorded CO COBALT (II) ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；298 K；11% PEG6000,10%PEG400,0.1M ADA, 20mM Mg acetate,20 mM Co acetate, pH 6.2, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.60 Å R-free 0.257
3S5I Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum Deposited 2011-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1193（1193 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；11% PEG6000, 10%PEG400, 0.1M ADA, 20mM Mg acetate, pH 6.2, VAPOR DIFFUSION, SITTING DROP, temperature 100K
Resolution 1.74 Å R-free 0.197
3S5K Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum Deposited 2011-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1193（1193 aa）
Not recorded ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.5；298 K；20% PEG6000, 0.1M MES, 5 M Zn acetate,0.1% - mercaptoethanol, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 3.20 Å R-free 0.316
3S5M Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium falciparum Deposited 2011-05-23 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 1–1193（1193 aa）
Not recorded ZN ZINC ION × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.2；298 K；11% PEG6000, 10% PEG400, 0.1M ADA, 20 mM Mg acetate, 20 mM Zn acetate, pH 6.2, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.55 Å R-free 0.214
7DI7 Falcilysin in complex with chloroquine Deposited 2020-11-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded ACT ACETATE ION × 2 CLQ N4-(7-CHLORO-QUINOLIN-4-YL)-N1,N1-DIETHYL-PENTANE-1,4-DIAMINE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium acetate trihydrate pH 8.0, 20% w/v PEG 3,350
Resolution 1.82 Å R-free 0.198
7DIA Falcilysin in complex with mefloquine Deposited 2020-11-18 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded H8O (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol × 1 GOL GLYCEROL × 1 ACT ACETATE ION × 3 YMZ (11R,12S)- Mefloquine × 1 EDO 1,2-ETHANEDIOL × 4 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M sodium acetate trihydrate pH 7.0, 20% w/v PEG 3,350
Resolution 1.55 Å R-free 0.197
7DIJ Falcilysin in complex with MK-4815 Deposited 2020-11-19 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded GOL GLYCEROL × 1 ACT ACETATE ION × 3 EDO 1,2-ETHANEDIOL × 3 DMS DIMETHYL SULFOXIDE × 1 H8F 2-(aminomethyl)-3,5-ditert-butyl-phenol × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；0.2 M ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v PEG 3,350
Resolution 1.90 Å R-free 0.206
8HO4 Falcilysin in complex with MMV000848 Deposited 2022-12-09 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded XUH (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol × 1 EDO 1,2-ETHANEDIOL × 3 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293.15 K；0.05 M Sodium HEPES, 0.05M MOPS pH 7.5, 0.03 M sodium nitrate, 0.03 M sodium phosphate dibasic, 0.03 M ammonium sulfate, 20% (v/v) PEG 500 MME, 10% (w/v) PEG 20,000
Resolution 1.96 Å R-free 0.206
8HO5 Falcilysin in complex with MMV665806 Deposited 2022-12-09 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded XUN (2S)-1-(2,3-dimethyl-1H-indol-1-yl)-3-{[(1S,2S)-2-methylcyclohexyl]amino}propan-2-ol × 1 GOL GLYCEROL × 1 EDO 1,2-ETHANEDIOL × 2 PEG DI(HYDROXYETHYL)ETHER × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 8.5；293.15 K；0.039M Bicine, 0.061M TRIZMA base pH 8.5, 0.03 M sodium nitrate, 0.03 M sodium phosphate dibasic, 0.03 M ammonium sulfate, 20% (v/v) PEG 500 MME, 10% (w/v) PEG 20,000
Resolution 2.00 Å R-free 0.189
8WXW Falcilysin in complex with hemoglobin alpha chain peptide Deposited 2023-10-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 59–1193（1135 aa）
Mutation：E132Q GOL GLYCEROL × 4 EDO 1,2-ETHANEDIOL × 1 ZN ZINC ION × 1 CL CHLORIDE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；4% w/v PEG 1500, 20% v/v glycerol
Resolution 1.86 Å R-free 0.210
8WXZ Falcilysin in complex with hemoglobin beta chain peptide Deposited 2023-10-30 Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count
Chain A 59–1193（1135 aa）
Mutation：E132Q PEG DI(HYDROXYETHYL)ETHER × 1 ACY ACETIC ACID × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293.15 K；0.12M monosaccharides, 0.1M imidazole/MES monohydrate pH 6.5, 20% v/v PEG 500, 10% w/v PEG 20000
Resolution 2.30 Å R-free 0.251
8WYT Partially closed Falcilysin bound to MK-4815, from MK-4815-treated dataset Deposited 2023-10-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1193（1135 aa）
Not recorded H8F 2-(aminomethyl)-3,5-ditert-butyl-phenol × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Na HEPES, 300 mM NaCl, 0.5 mM TCEP, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 2.70 Å
8WYU Open Falcilysin, from MK-4815-treated dataset Deposited 2023-10-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 61–1193（1133 aa）
Not recorded ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Na HEPES, 300 mM NaCl, 0.5 mM TCEP, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.20 Å
8WYX Partially closed falcilysin, from free falcilysin dataset Deposited 2023-10-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 59–1192（1134 aa）
Not recorded ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Na HEPES, 300 mM NaCl, 0.5 mM TCEP, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.50 Å
8WYY Open falcilysin, from free falcilysin dataset Deposited 2023-10-31 Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count
Chain A 61–1193（1133 aa）
Not recorded ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM buffer pH 7.5；20 mM Na HEPES, 300 mM NaCl, 0.5 mM TCEP, pH 7.5
cryo-EM vitrification conditions Cryogen ETHANE
Resolution 3.10 Å

This page presents structural evidence recorded in PDB/mmCIF.“No recorded non-water small molecule” does not prove that the experimental sample was ligand-free; experimental conditions belong to the PDB experiment, while ligands and copy counts are shown for each biological assembly.