Current Protein Identity：Q7NDN8
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2XQ3 Pentameric ligand gated ion channel GLIC in complex with Br-lidocaine Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | BR BROMIDE ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.50 Å R-free 0.257 |
| 2XQ4 Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ARS ARSENIC × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.60 Å R-free 0.272 |
| 2XQ5 Pentameric ligand gated ion channel GLIC in complex with tetraethylarsonium (TEAs) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ARS ARSENIC × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50 MM CH3COONA, 200 MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277K.
|
Resolution 3.50 Å R-free 0.266 |
| 2XQ6 Pentameric ligand gated ion channel GLIC in complex with cesium ion (Cs+) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | CS CESIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG4000, 50MM CH3COONA, 225MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.70 Å R-free 0.258 |
| 2XQ7 Pentameric ligand gated ion channel GLIC in complex with cadmium ion (Cd2+) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | CD CADMIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG 4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP.
|
Resolution 3.40 Å R-free 0.266 |
| 2XQ8 Pentameric ligand gated ion channel GLIC in complex with zinc ion (Zn2+) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | ZN ZINC ION × 3 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.60 Å R-free 0.248 |
| 2XQ9 Pentameric ligand gated ion channel GLIC mutant E221A in complex with tetraethylarsonium (TEAs) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | ARS ARSENIC × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；9% PEG 4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH 4.0, VAPOR DIFFUSION, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP.
|
Resolution 3.20 Å R-free 0.257 |
| 2XQA Pentameric ligand gated ion channel GLIC in complex with tetrabutylantimony (TBSb) Deposited 2010-09-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain B
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain C
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain D
43–359（317 aa）
Fragment：RESIDUES 43-359
Chain E
43–359（317 aa）
Fragment：RESIDUES 43-359
|
Not recorded | SB ANTIMONY (III) ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50MM CH3COONA, 200MM (NH4)2SO4, PH4.0, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.70 Å R-free 0.274 |
| 3EAM An open-pore structure of a bacterial pentameric ligand-gated ion channel Deposited 2008-08-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；PEG 4000, NH4SCN, NaAc, pH 4.6, vapor diffusion, hanging drop, temperature 298K
|
Resolution 2.90 Å R-free 0.231 |
| 3EHZ X-ray structure of the pentameric ligand gated ion channel of Gloebacter violaceus (GLIC) in a presumptive open conformation Deposited 2008-09-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
50–359（310 aa）
Fragment：UNP residues 50-359
Chain B
50–359（310 aa）
Fragment：UNP residues 50-359
Chain C
50–359（310 aa）
Fragment：UNP residues 50-359
Chain D
50–359（310 aa）
Fragment：UNP residues 50-359
Chain E
50–359（310 aa）
Fragment：UNP residues 50-359
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50mM CH3COONa, 200mM (NH4)2SO4, pH4.0, vapor diffusion, hanging drop, temperature 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.10 Å R-free 0.266 |
| 3EI0 Structure of the E221A mutant of the Gloebacter violaceus pentameric ligand gated ion channnel (GLIC) Deposited 2008-09-15 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
50–359（310 aa）
Fragment：UNP residues 50-359
Chain B
50–359（310 aa）
Fragment：UNP residues 50-359
Chain C
50–359（310 aa）
Fragment：UNP residues 50-359
Chain D
50–359（310 aa）
Fragment：UNP residues 50-359
Chain E
50–359（310 aa）
Fragment：UNP residues 50-359
|
Mutation：E221A Mutation：E221A Mutation：E221A Mutation：E221A Mutation：E221A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；277.15 K；9% PEG4000, 50mM CH3COONa, 500mM (NH4)2SO4, pH4.0, vapor diffusion, hanging drop, temperature 277.15K, VAPOR DIFFUSION, HANGING DROP
|
Resolution 3.50 Å R-free 0.276 |
| 3IGQ Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel Deposited 2009-07-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain A
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain B
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain C
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
|
Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S | ACY ACETIC ACID × 6 NA SODIUM ION × 6 HG MERCURY (II) ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.255 |
| 3IGQ Crystal structure of the extracellular domain of a bacterial pentameric ligand-gated ion channel Deposited 2009-07-28 | Assembly 2 Protein homooligomer Homooligomer；Protein × 6 PDB declaration: hexameric（6） Consistent with protein count |
Chain D
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain E
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
Chain F
44–235（192 aa）
Fragment：extracellular N-terminal fragment, UNP residues 44-235
|
Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S Mutation：F116G, Y119T, P120E, F121S | ACY ACETIC ACID × 6 NA SODIUM ION × 6 HG MERCURY (II) ION × 6 CL CHLORIDE ION × 6 | X-RAY DIFFRACTION | mmCIF provides none of the parsed conditions | Resolution 2.30 Å R-free 0.255 |
| 3LSV Structure of the A237F mutant of the pentameric ligand gated ion channel from Gloeobacter Violaceus Deposited 2010-02-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：A279F Mutation：A279F Mutation：A279F Mutation：A279F Mutation：A279F | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PEG 4000 ~25%, NaSCN ~400 mM, NaAc ph 4 100 mM, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.15 Å R-free 0.224 |
| 3P4W Structure of desflurane bound to a pentameric ligand-gated ion channel, GLIC Deposited 2010-10-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain B
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain C
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain D
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain E
44–359（316 aa）
Fragment：residues in UNP 44-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 DSF (2S)-2-(difluoromethoxy)-1,1,1,2-tetrafluoroethane × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；pH 4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.20 Å R-free 0.206 |
| 3P50 Structure of propofol bound to a pentameric ligand-gated ion channel, GLIC Deposited 2010-10-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain B
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain C
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain D
44–359（316 aa）
Fragment：residues in UNP 44-359
Chain E
44–359（316 aa）
Fragment：residues in UNP 44-359
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.30 Å R-free 0.203 |
| 3TLS The GLIC pentameric Ligand-Gated Ion Channel E19'P mutant in a locally-closed conformation (LC2 subtype) Deposited 2011-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：E285P Mutation：E285P Mutation：E285P Mutation：E285P Mutation：E285P | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 3.20 Å R-free 0.230 |
| 3TLT The GLIC pentameric Ligand-Gated Ion Channel H11'F mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：H277F Mutation：H277F Mutation：H277F Mutation：H277F Mutation：H277F | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 3.30 Å R-free 0.243 |
| 3TLU The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' oxidized mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C Mutation：C69S/K75C/K290C | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.85 Å R-free 0.223 |
| 3TLV The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' oxidized mutant in a locally-closed conformation (LC3 subtype) Deposited 2011-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C Mutation：C69S/K75C/L288C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.90 Å R-free 0.229 |
| 3TLW The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' oxidized mutant in a locally-closed conformation (LC2 subtype) Deposited 2011-08-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C Mutation：C69S/K75C/N287C | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4；293 K；pH 4, VAPOR DIFFUSION, temperature 293K
|
Resolution 2.60 Å R-free 0.225 |
| 3UU3 The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' oxidized mutant in a locally-closed conformation (LC1 subtype) Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C | LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.15 Å R-free 0.272 |
| 3UU4 The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in the crystal in a locally-closed conformation (LC1 subtype) Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C | LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.05 Å R-free 0.241 |
| 3UU5 The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' mutant reduced in solution Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C Mutation：C27S,K33C,T244C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.218 |
| 3UU6 The GLIC pentameric Ligand-Gated Ion Channel Loop2-22' mutant reduced in solution Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C Mutation：C27S,K33C,L246C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.98 Å R-free 0.241 |
| 3UU8 The GLIC pentameric Ligand-Gated Ion Channel Loop2-24' mutant reduced in solution Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C Mutation：C27S,K33C,K248C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.25 Å R-free 0.234 |
| 3UUB The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution Deposited 2011-11-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 CL CHLORIDE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.221 |
| 3UUB The GLIC pentameric Ligand-Gated Ion Channel Loop2-21' mutant reduced in solution Deposited 2011-11-28 | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain F
44–359（316 aa）
Fragment：UNP residues 44-359
Chain G
44–359（316 aa）
Fragment：UNP residues 44-359
Chain H
44–359（316 aa）
Fragment：UNP residues 44-359
Chain I
44–359（316 aa）
Fragment：UNP residues 44-359
Chain J
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C Mutation：C27S,K33C,N245C | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 CL CHLORIDE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15% PEG4000, 0.4 M sodium thiocyanate, 0.1 M sodium acetate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.90 Å R-free 0.221 |
| 4F8H X-ray Structure of the Anesthetic Ketamine Bound to the GLIC Pentameric Ligand-gated Ion Channel Deposited 2012-05-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | RKE (R)-ketamine × 5 LMD tetradecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；10-12% PEG 4000, 225 mM ammonium sulfate, 50 mM sodium acetate buffer (pH 3.9 - 4.1), VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 2.99 Å R-free 0.219 |
| 4HFB The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo) Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.75 Å R-free 0.222 |
| 4HFC The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to 2-bromo-ethanol Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：unp residues 44-359
Chain B
44–359（316 aa）
Fragment：unp residues 44-359
Chain C
44–359（316 aa）
Fragment：unp residues 44-359
Chain D
44–359（316 aa）
Fragment：unp residues 44-359
Chain E
44–359（316 aa）
Fragment：unp residues 44-359
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | LMT DODECYL-BETA-D-MALTOSIDE × 6 BRJ 2-BROMOETHANOL × 5 CL CHLORIDE ION × 7 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 ACT ACETATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate pH4, 0.4M NaSCN, 200 mM 2-bromo-ethanol, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.05 Å R-free 0.220 |
| 4HFD The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to bromoform Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 2% bromoform, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.10 Å R-free 0.208 |
| 4HFE The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to ethanol Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：unp residues 44-359
Chain B
44–359（316 aa）
Fragment：unp residues 44-359
Chain C
44–359（316 aa）
Fragment：unp residues 44-359
Chain D
44–359（316 aa）
Fragment：unp residues 44-359
Chain E
44–359（316 aa）
Fragment：unp residues 44-359
|
Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A Mutation：F280A | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 EOH ETHANOL × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 UNL UNKNOWN LIGAND × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 0.2M Ethanol, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.80 Å R-free 0.215 |
| 4HFH The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate, 0.4M NaSCN, 2% bromoform, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.65 Å R-free 0.213 |
| 4HFI The GLIC pentameric Ligand-Gated Ion Channel at 2.4 A resolution Deposited 2012-10-05 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12-15% PEG4K, 0.1M Na Acetate pH4, 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.40 Å R-free 0.216 |
| 4IL4 The pentameric ligand-gated ion channel GLIC in complex with Se-DDM Deposited 2012-12-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LSM dodecyl 4-O-alpha-D-glucopyranosyl-1-seleno-beta-D-glucopyranoside × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；12.5-15% PEG4000, 0.1M NaAcetate pH4, 0.4M NaSCN, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.30 Å R-free 0.209 |
| 4IL9 The pentameric ligand-gated ion channel GLIC A237F in complex with bromide Deposited 2012-12-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 BR BROMIDE ION × 12 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH 4, 0.2M NaSCN, 0.2M NaBr, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.83 Å R-free 0.214 |
| 4ILA The pentameric ligand-gated ion channel GLIC A237F in complex with Cesium Deposited 2012-12-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CS CESIUM ION × 27 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH 4, 0.2M NaSCN, 0.2M CsCl, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.50 Å R-free 0.208 |
| 4ILB The pentameric ligand-gated ion channel GLIC A237F in complex with Rubidium Deposited 2012-12-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F Mutation：A237F | LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 RB RUBIDIUM ION × 1 ACT ACETATE ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH4, 0.2M NaSCN, 0.2M RbCl, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 3.15 Å R-free 0.226 |
| 4ILC The GLIC pentameric ligand-gated ion channel in complex with sulfates Deposited 2012-12-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–358（315 aa）
Fragment：UNP residues 44-358
Chain B
44–358（315 aa）
Fragment：UNP residues 44-358
Chain C
44–358（315 aa）
Fragment：UNP residues 44-358
Chain D
44–358（315 aa）
Fragment：UNP residues 44-358
Chain E
44–358（315 aa）
Fragment：UNP residues 44-358
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 UNL UNKNOWN LIGAND × 10 CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 6 SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15% PEG 4K, 0.1M Na Acetate pH4, 0.2M NH4SO4, VAPOR DIFFUSION, HANGING DROP, temperature 290K
|
Resolution 2.99 Å R-free 0.236 |
| 4IRE Crystal structure of GLIC with mutations at the loop C region Deposited 2013-01-14 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N Mutation：D91N, E177Q, D178N | LMD tetradecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 10 OXL OXALATE ION × 17 ACT ACETATE ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 3.9；277 K；10-12% PEG 4000, 225 mM ammonium sulfate, 50 mM sodium acetate buffer (pH 3.9 - 4.1), VAPOR DIFFUSION, SITTING DROP, temperature 277K
|
Resolution 3.19 Å R-free 0.243 |
| 4LMJ GLIC Liganded-closed-channel Conformation, Mutant T25'A Deposited 2013-07-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：T291A Mutation：T291A Mutation：T291A Mutation：T291A Mutation：T291A | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.44 Å R-free 0.255 |
| 4LMK GLIC Liganded-closed-channel Conformation, Mutant Y27'A Deposited 2013-07-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：T293A Mutation：T293A Mutation：T293A Mutation：T293A Mutation：T293A | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.22 Å R-free 0.238 |
| 4LML GLIC double mutant I9'A T25'A Deposited 2013-07-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A Mutation：I275A,T291A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；10-12% PEG4000, 225 mM ammonium sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.80 Å R-free 0.302 |
| 4NPP The GLIC-His10 wild-type structure in equilibrium between the open and locally-closed (LC) forms Deposited 2013-11-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | NI NICKEL (II) ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；15-20% PEG2kmme, 50mM NiCl2, 0.1M Na Acetate pH4, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 3.35 Å R-free 0.248 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain F
44–359（316 aa）
Chain G
44–359（316 aa）
Chain H
44–359（316 aa）
Chain I
44–359（316 aa）
Chain J
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Assembly 3 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain K
44–359（316 aa）
Chain L
44–359（316 aa）
Chain M
44–359（316 aa）
Chain N
44–359（316 aa）
Chain O
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4NPQ The resting-state conformation of the GLIC ligand-gated ion channel Deposited 2013-11-22 | Assembly 4 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain P
44–359（316 aa）
Chain Q
44–359（316 aa）
Chain R
44–359（316 aa）
Chain S
44–359（316 aa）
Chain T
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；13-15% PEG4000, 200mM KSCN, 10mM CaCl2, 3% Trimethylamine-N-oxyde dihydrate, 0.1M Na Hepes pH7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 4.35 Å R-free 0.244 |
| 4QH1 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) in complex with bromoacetate Deposited 2014-05-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | BR BROMIDE ION × 5 BXA bromoacetic acid × 10 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate, 100 mM Sodium acetate, 16% glycerol, 12-15% PEG4000
2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.40 Å R-free 0.225 |
| 4QH4 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in acetate buffer at pH3 Deposited 2014-05-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 ACT ACETATE ION × 3 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate 100 mM Sodium acetate,
16% glycerol, 12-15% PEG4000, 2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.20 Å R-free 0.224 |
| 4QH5 The GLIC pentameric Ligand-Gated Ion Channel (wild-type) crystallized in phosphate buffer Deposited 2014-05-26 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 CL CHLORIDE ION × 5 NA SODIUM ION × 4 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；400 mM Sodium Isothiocyanate, 100 mM Sodium acetate, 16% glycerol, 12-15% PEG4000, 2% DMSO, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 3.00 Å R-free 0.216 |
| 4X5T alpha 1 glycine receptor transmembrane structure fused to the extracellular domain of GLIC Deposited 2014-12-05 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–235（192 aa）
Chain B
44–235（192 aa）
Chain C
44–235（192 aa）
Chain D
44–235（192 aa）
Chain E
44–235（192 aa）
|
Not recorded | NI NICKEL (II) ION × 6 CL CHLORIDE ION × 6 ACT ACETATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3；291 K；16 % PEG 2000MME, 50 mM NiCl2, 4% DMSO, 11% ethylene glycol and 0.1 M NaAcetate pH 3.0
|
Resolution 3.50 Å R-free 0.270 |
| 4YEU ELIC-GLIC chimera in the resting conformation Deposited 2015-02-24 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
236–357（122 aa）
Chain B
236–357（122 aa）
Chain C
236–357（122 aa）
Chain D
236–357（122 aa）
Chain E
236–357（122 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；277 K；PEG 4000, Ammonium Sulfate, Sodium ADA
|
Resolution 4.60 Å R-free 0.248 |
| 4ZZB The GLIC pentameric Ligand-Gated Ion Channel Locally-closed form complexed to xenon Deposited 2015-05-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C Mutation：C27S K33C L246C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 NA SODIUM ION × 5 ACT ACETATE ION × 6 XE XENON × 21 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；290 K；12-15 % PEG4000
0.1M Na Acetate pH4
0.4M NaSCN
15% glycerol
5% DMSO
|
Resolution 3.40 Å R-free 0.223 |
| 4ZZC The GLIC pentameric Ligand-Gated Ion Channel open form complexed to xenon Deposited 2015-05-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: Pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 XE XENON × 30 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；290 K；12-15% PEG4000
0.1M Na Acetate pH4
0.4M NaSCN
15% glycerol
5% DMSO
|
Resolution 3.10 Å R-free 0.228 |
| 5HCJ Cationic Ligand-Gated Ion Channel Deposited 2016-01-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C Mutation：C27S, K33C, L246C | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 NA SODIUM ION × 1 MBR TRIBROMOMETHANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；PEG4000 12-15%, NaSCN 0.4M, 15% glycerol, NaAcetate pH 4 0.1M
|
Resolution 2.95 Å R-free 0.218 |
| 5HCM The GLIC pentameric Ligand-Gated Ion Channel 2-21' cross-linked mutant complexed to bromoform Deposited 2016-01-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP residues 44-359
Chain B
44–359（316 aa）
Fragment：UNP residues 44-359
Chain C
44–359（316 aa）
Fragment：UNP residues 44-359
Chain D
44–359（316 aa）
Fragment：UNP residues 44-359
Chain E
44–359（316 aa）
Fragment：UNP residues 44-359
|
Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C Mutation：C27S, K33C, N245C | LMT DODECYL-BETA-D-MALTOSIDE × 1 MBR TRIBROMOMETHANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；PEG 4000 12-15%, 0.1 M Na Acetate pH4, 0.4M NaSCN, 15% glycerol
|
Resolution 3.15 Å R-free 0.240 |
| 5HEG Pentameric ligand-gated ion channel GLIC mutant P246G Deposited 2016-01-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：P246G Mutation：P246G Mutation：P246G Mutation：P246G Mutation：P246G | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；Ammonium sulfate, PEG 4000
|
Resolution 3.21 Å R-free 0.258 |
| 5HEH Pentameric ligand-gated ion channel GLIC mutant P246A Deposited 2016-01-06 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Mutation：P246A Mutation：P246A Mutation：P246A Mutation：P246A Mutation：P246A | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；PEG 4000, Ammonium Sulfate
|
Resolution 3.30 Å R-free 0.280 |
| 5IUX GLIC-V135C bimane labelled X-ray structure Deposited 2016-03-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 15 ACT ACETATE ION × 10 6E3 2,3,5,6-tetramethyl-1H,7H-pyrazolo[1,2-a]pyrazole-1,7-dione × 2 BR BROMIDE ION × 5 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；12% PEG4K, 15% DMSO, 100 mM Acetate de Sodium pH4, 200 mM Sodium isothiocyanate, 2% DMSO
|
Resolution 2.60 Å R-free 0.237 |
| 5J0Z Crystal structure of GLIC in complex with DHA Deposited 2016-03-28 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | CL CHLORIDE ION × 3 LMT DODECYL-BETA-D-MALTOSIDE × 6 SO4 SULFATE ION × 6 ACT ACETATE ION × 2 HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4；277 K；225 mM ammonium sulfate, 50 mM sodium acetate pH 4.0, 7.5-10% PEG 4000
|
Resolution 3.25 Å R-free 0.261 |
| 5L47 X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with cyanoselenobarbital (seleniated barbiturate) Deposited 2016-05-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 5 ACT ACETATE ION × 5 NA SODIUM ION × 4 6JA 2-[5-ethyl-2,4,6-tris(oxidanylidene)-1,3-diazinan-5-yl]ethyl selenocyanate × 1 D12 DODECANE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；100 mM Na Acetate pH4, 200 mM Na SCN, 12-15% PEG4000, 3% DMSO, 16% glycerol
|
Resolution 3.30 Å R-free 0.230 |
| 5L4E X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with thiopental Deposited 2016-05-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | D12 DODECANE × 1 CL CHLORIDE ION × 5 EDP 5-ethyl-5-[(2R)-pentan-2-yl]-2-thioxodihydropyrimidine-4,6(1H,5H)-dione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；291 K；100 mM NaAcetate pH4
200 NaSCN
12-15% PEG4000
16% glycerol
3%DMSO
|
Resolution 3.50 Å R-free 0.249 |
| 5L4H X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate) Deposited 2016-05-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 6JW 5-(2-bromoethyl)-5-ethyl-1,3-diazinane-2,4,6-trione × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM NaAcetate pH4, 200 mM NaSCN, 12-15% PEG4000, 16% glycerol, 3% DMSO
|
Resolution 3.30 Å R-free 0.235 |
| 5MUO X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol Deposited 2017-01-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain B
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain C
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain D
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain E
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | LMT DODECYL-BETA-D-MALTOSIDE × 1 CL CHLORIDE ION × 5 ACT ACETATE ION × 4 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K
|
Resolution 3.19 Å R-free 0.204 |
| 5MUR X-ray structure of the F14'A mutant of GLIC in complex with propofol Deposited 2017-01-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP residues 43-359
Chain B
43–359（317 aa）
Fragment：UNP residues 43-359
Chain C
43–359（317 aa）
Fragment：UNP residues 43-359
Chain D
43–359（317 aa）
Fragment：UNP residues 43-359
Chain E
43–359（317 aa）
Fragment：UNP residues 43-359
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na acetate pH4
12-15% PEG4K
200 mM NaSCN
16% glycerol
2% DMSO
|
Resolution 3.10 Å R-free 0.204 |
| 5MVM X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol Deposited 2017-01-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 6 ACT ACETATE ION × 10 CL CHLORIDE ION × 5 NA SODIUM ION × 7 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400mM NaSCN
100mM NaAcetate pH4
12-15% PEG4K
16% glycerol
2% DMSO
|
Resolution 3.10 Å R-free 0.208 |
| 5MVN X-ray structure of the M205W mutant of GLIC in complex with propofol Deposited 2017-01-16 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400 mM NaSCN
100 mM NaAcetate pH4
12-15 % PEG4K
16 % glycerol
2 % DMSO
|
Resolution 3.49 Å R-free 0.232 |
| 5MZQ X-ray structure of the M205W mutant of GLIC in complex with bromoform Deposited 2017-02-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PC8 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 5 2IL (3R)-3-(dodecanoyloxy)tetradecanoic acid × 5 D12 DODECANE × 11 CL CHLORIDE ION × 7 NA SODIUM ION × 6 MBR TRIBROMOMETHANE × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；100 mM NaAct pH4
400 mM NaSCN
16% glycerol 2% DMSO
12-15 % PEG4K
|
Resolution 2.80 Å R-free 0.219 |
| 5MZR X-ray structure of the H235Q mutant of GLIC in complex with propofol Deposited 2017-02-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Mutation：H235Q Mutation：H235Q Mutation：H235Q Mutation：H235Q Mutation：H235Q | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PFL 2,6-BIS(1-METHYLETHYL)PHENOL × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；100 mM NaAct pH4
400 mM NaSCN
16% glycerol
2% DMSO
12-15% PEG4K
|
Resolution 2.65 Å R-free 0.210 |
| 5MZT X-ray structure of the H235Q mutant of GLIC in complex with bromoform Deposited 2017-02-01 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：H235Q
Chain B
43–359（317 aa）
Fragment：H235Q
Chain C
43–359（317 aa）
Fragment：H235Q
Chain D
43–359（317 aa）
Fragment：H235Q
Chain E
43–359（317 aa）
Fragment：H235Q
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 MBR TRIBROMOMETHANE × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；294 K；100 mM NaAct pH 4
400 mM NaSCN
16% glycerol
2% DMSO
|
Resolution 2.65 Å R-free 0.211 |
| 5NJY X-ray structure of the H235Q mutant of GLIC Deposited 2017-03-30 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；400 mM NaSCN
100 mM Na Acetate pH 4
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 2.95 Å R-free 0.243 |
| 5NKJ X-ray structure of the N239C mutant of GLIC Deposited 2017-03-31 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K
|
Resolution 3.74 Å R-free 0.256 |
| 5OSA GLIC-GABAAR alpha1 chimera crystallized at pH4.6 Deposited 2017-08-17 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | ACT ACETATE ION × 8 CL CHLORIDE ION × 7 D12 DODECANE × 8 Y01 CHOLESTEROL HEMISUCCINATE × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；289.15 K；100 mM NaCl, 100 mM sodium acetate pH 4.6, 12 % PEG 6000
|
Resolution 2.75 Å R-free 0.229 |
| 5OSB GLIC-GABAAR alpha1 chimera crystallized in complex with THDOC at pH4.5 Deposited 2017-08-17 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | A8Z Tetrahydrodeoxycorticosterone × 5 ACT ACETATE ION × 5 CL CHLORIDE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；289 K；12-16% PEG4000, 100mM NaCl, 100 mM Li2SO4, 100mM sodium acetate pH4-4.5
|
Resolution 3.80 Å R-free 0.290 |
| 5OSC GLIC-GABAAR alpha1 chimera crystallized in complex with pregnenolone sulfate at pH 4.5 Deposited 2017-08-17 | Assembly 1 Insufficient information Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–236（193 aa）
Chain B
44–236（193 aa）
Chain C
44–236（193 aa）
Chain D
44–236（193 aa）
Chain E
44–236（193 aa）
|
Not recorded | ACT ACETATE ION × 8 CL CHLORIDE ION × 5 A8W Pregnenolone sulfate × 5 Y01 CHOLESTEROL HEMISUCCINATE × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.5；289 K；12-16% PEG 4000, 100 mM NaCl, 100 mM Li2S04, 100 mM sodium acetate pH 4-5
|
Resolution 3.10 Å R-free 0.246 |
| 5V6N Crystal Structure of the highly open channel-stabilized mutant C27S + K33C + I9'A + N21'C of GLIC under reducing conditions. Deposited 2017-03-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
50–359（310 aa）
Fragment：unp residues 50-359
Chain B
50–359（310 aa）
Fragment：unp residues 50-359
Chain C
50–359（310 aa）
Fragment：unp residues 50-359
Chain D
50–359（310 aa）
Fragment：unp residues 50-359
Chain E
50–359（310 aa）
Fragment：unp residues 50-359
|
Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C Mutation：C69S, K75C, I275A, N287C | LMT DODECYL-BETA-D-MALTOSIDE × 5 NA SODIUM ION × 1 SO4 SULFATE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；200-250 mM (NH4)2SO4,
10-12% (wt/vol) PEG-4000
50 mM sodium acetate, pH 3.9-4.2
|
Resolution 3.35 Å R-free 0.284 |
| 5V6O Crystal Structure of the highly open channel-stabilized mutant G-2'I + I9'A of GLIC Deposited 2017-03-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
50–359（310 aa）
Fragment：unp residues 50-359
Chain B
50–359（310 aa）
Fragment：unp residues 50-359
Chain C
50–359（310 aa）
Fragment：unp residues 50-359
Chain D
50–359（310 aa）
Fragment：unp residues 50-359
Chain E
50–359（310 aa）
Fragment：unp residues 50-359
|
Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C Mutation：C27S, K33C | LMT DODECYL-BETA-D-MALTOSIDE × 6 CL CHLORIDE ION × 5 NA SODIUM ION × 1 SO4 SULFATE ION × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；277 K；Sodium Acetate 50 mM pH 3.9-4.2
Ammonium Sulfate 200-250 mM
PEG 4000 10-12%
|
Resolution 3.12 Å R-free 0.280 |
| 6EMX X-ray structure of the N15'C mutant of GLIC in complex with bromoform Deposited 2017-10-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 4 NA SODIUM ION × 6 MBR TRIBROMOMETHANE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；291 K；12-14% PEGK
400mM NaSCN
100 mM NaAcetate pH 4
15% glycerol
3% DMSO
|
Resolution 3.20 Å R-free 0.268 |
| 6F0I GLIC mutant E26A Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；291.15 K；PEG 4000, 15% Glycerol, 0.1M Sodium acetate, 0.4M Thiocyanate, 3% DMSO
|
Resolution 3.00 Å R-free 0.223 |
| 6F0J GLIC mutant E26A Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；292 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 3.15 Å R-free 0.222 |
| 6F0M GLIC mutant E35Q Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.65 Å R-free 0.222 |
| 6F0N GLIC mutant E82A Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 3.20 Å R-free 0.233 |
| 6F0R GLIC mutant E82Q Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 CL CHLORIDE ION × 4 LMT DODECYL-BETA-D-MALTOSIDE × 6 NA SODIUM ION × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.50 Å R-free 0.254 |
| 6F0U GLIC mutant E35A Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.35 Å R-free 0.233 |
| 6F0V GLIC mutant E82Q Deposited 2017-11-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 200 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.85 Å R-free 0.221 |
| 6F0Z GLIC mutant D88N Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；12% PEG4K, 15% glycerol, 100 mM Acetate de Sodium pH4, 400 mM Sodium isothiocyanate, 3% DMSO
|
Resolution 2.50 Å R-free 0.226 |
| 6F10 GLIC mutant D88N Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 mM NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.85 Å R-free 0.223 |
| 6F11 GLIC mutant D86A Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 mM NaSCN 12-15% PEG 4000 15% glycerol 3%DMSO
|
Resolution 2.95 Å R-free 0.215 |
| 6F12 GLIC mutant E181A Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 ACT ACETATE ION × 10 LMT DODECYL-BETA-D-MALTOSIDE × 6 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH4 400 NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 3.20 Å R-free 0.213 |
| 6F13 GLIC mutant E75A Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 200mM NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.70 Å R-free 0.223 |
| 6F15 GLIC mutant H127Q Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 400mM NaSCN 12-15% PEG4000 165% glycerol 3%DMSO
|
Resolution 2.85 Å R-free 0.229 |
| 6F16 GLIC mutant H277Q Deposited 2017-11-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；293 K；100 mM NaAcetate pH 4 400 NaSCN 12-15% PEG4000 15% glycerol 3%DMSO
|
Resolution 2.60 Å R-free 0.219 |
| 6F7A Gloeobacter Ligand-gated Ion Channel (GLIC) closed state crystallized in an ultra-swollen lipidic mesophase Deposited 2017-12-07 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | No recorded non-water small molecule | X-RAY DIFFRACTION |
X-ray crystallization conditions
LIPIDIC CUBIC PHASE；298 K；0.2 M (NH4)SO4, 0.02M NaCl, 0.02M Na Act 4 pH, 33%v/v PEG200
|
Resolution 6.00 Å R-free 0.318 |
| 6HJ3 Xray structure of GLIC in complex with fumarate Deposited 2018-08-31 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 12 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 FUM FUMARIC ACID × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；30 mM Na fumarate pH 4
12-15% PEG4000
400 mM Na Isothiocyanate
15% glycerol
2% DMSO
|
Resolution 2.70 Å R-free 0.216 |
| 6HJA Xray structure of GLIC in complex with glutarate Deposited 2018-09-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–359（359 aa）
Chain B
1–359（359 aa）
Chain C
1–359（359 aa）
Chain D
1–359（359 aa）
Chain E
1–359（359 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 14 CL CHLORIDE ION × 11 D12 DODECANE × 6 GUA GLUTARIC ACID × 5 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM Na-Acetate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 2.70 Å R-free 0.219 |
| 6HJB Xray structure of GLIC in complex with malonate Deposited 2018-09-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
1–359（359 aa）
Chain B
1–359（359 aa）
Chain C
1–359（359 aa）
Chain D
1–359（359 aa）
Chain E
1–359（359 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 11 CL CHLORIDE ION × 11 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 MLA MALONIC ACID × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；291 K；100 mM Na-malonate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
16% Glycerol
|
Resolution 3.00 Å R-free 0.199 |
| 6HJI Xray structure of GLIC in complex with crotonate Deposited 2018-09-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 12 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 BEO BUTENOIC ACID × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na-crotonate pH4
400 mM Na-Isothiocyanate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.80 Å R-free 0.204 |
| 6HJZ Xray structure of GLIC in complex with succinate Deposited 2018-09-04 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 SIN SUCCINIC ACID × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；100 mM NaSuccinate pH4
400 mM NaIsothiocynate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.50 Å R-free 0.227 |
| 6HJZ Xray structure of GLIC in complex with succinate Deposited 2018-09-04 | Assembly 2 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain F
43–359（317 aa）
Chain G
43–359（317 aa）
Chain H
43–359（317 aa）
Chain I
43–359（317 aa）
Chain J
43–359（317 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 SIN SUCCINIC ACID × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；100 mM NaSuccinate pH4
400 mM NaIsothiocynate
12-15% PEG4000
2% DMSO
15% glycerol
|
Resolution 2.50 Å R-free 0.227 |
| 6HPP X-ray structure of GLIC in complex with propionate Deposited 2018-09-21 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 PPI PROPANOIC ACID × 10 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Na-propionate, pH 4
400 mM NaIsothiocyanate
12-15% PEG4000
2% DMSO
15% glycreol
|
Resolution 3.20 Å R-free 0.201 |
| 6HY5 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C Deposited 2018-10-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；12-15% PEG4K, 0.1M NA ACETATE PH4,
0.4M NASCN, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
|
Resolution 2.58 Å R-free 0.205 |
| 6HY9 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193M Deposited 2018-10-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain B
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain C
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain D
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
Chain E
44–359（316 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 291K. 12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.95 Å R-free 0.227 |
| 6HYA THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193L Deposited 2018-10-19 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K;12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.39 Å R-free 0.212 |
| 6HYR THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Q193C+MMTS Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–357（311 aa）
Chain B
47–357（311 aa）
Chain C
47–357（311 aa）
Chain D
47–357（311 aa）
Chain E
47–357（311 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.50 Å R-free 0.241 |
| 6HYV THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119A Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | LMT DODECYL-BETA-D-MALTOSIDE × 11 ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 2.80 Å R-free 0.221 |
| 6HYW THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y119F Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 10 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.80 Å R-free 0.212 |
| 6HYX THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT Y197F-P250C Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 NA SODIUM ION × 7 LMT DODECYL-BETA-D-MALTOSIDE × 1 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K.12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.00 Å R-free 0.224 |
| 6HYZ THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248C Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.05 Å R-free 0.234 |
| 6HZ0 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT K248A Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.75 Å R-free 0.238 |
| 6HZ1 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 6 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；291 K；12-15% PEG4K, 0.1M NA ACETATE PH4,
0.4M NASCN, VAPOR DIFFUSION, HANGING DROP, TEMPERATURE 291K
|
Resolution 2.50 Å R-free 0.216 |
| 6HZ3 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243G Deposited 2018-10-22 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K,12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4
|
Resolution 3.15 Å R-free 0.249 |
| 6HZW THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL 2.22 resolution Deposited 2018-10-24 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Chain B
43–359（317 aa）
Chain C
43–359（317 aa）
Chain D
43–359（317 aa）
Chain E
43–359（317 aa）
|
Not recorded | ACT ACETATE ION × 10 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 15 CL CHLORIDE ION × 7 NA SODIUM ION × 6 LMT DODECYL-BETA-D-MALTOSIDE × 11 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；291 K；12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 2.22 Å R-free 0.220 |
| 6I08 THE GLIC PENTAMERIC LIGAND-GATED ION CHANNEL MUTANT E243C-I201W Deposited 2018-10-25 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain B
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain C
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain D
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
Chain E
43–359（317 aa）
Fragment：UNP RESIDUES 44-359
|
Mutation：YES Mutation：YES Mutation：YES Mutation：YES Mutation：YES | CL CHLORIDE ION × 5 PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 5 LMT DODECYL-BETA-D-MALTOSIDE × 1 NA SODIUM ION × 7 | X-RAY DIFFRACTION |
X-ray crystallization conditions
EVAPORATION；pH 4；293 K；PH 4, VAPOR DIFFUSION, TEMPERATURE 293K 12-14.5% PEG4K; 15% GLycerol; 400 mM NaSCN; 3% DMSO; 100mM NaAcetate pH 4.
|
Resolution 3.00 Å R-free 0.228 |
| 6ZGD GLIC pentameric ligand-gated ion channel, pH 7 Deposited 2020-06-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 4.10 Å |
| 6ZGJ GLIC pentameric ligand-gated ion channel, pH 5 Deposited 2020-06-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 3.40 Å |
| 6ZGK GLIC pentameric ligand-gated ion channel, pH 3 Deposited 2020-06-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 3
cryo-EM vitrification conditions
Cryogen ETHANE；blot for 1.5 s
force -1
|
Resolution 3.60 Å |
| 8ATG Pentameric ligand-gated ion channel GLIC with bound lipids Deposited 2022-08-23 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
44–359（316 aa）
Chain B
44–359（316 aa）
Chain C
44–359（316 aa）
Chain D
44–359（316 aa）
Chain E
44–359（316 aa）
|
Not recorded | POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 25 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.90 Å |
| 8I41 Cryo-EM structure of nanodisc (asolectin) reconstituted GLIC at pH 7.5 Deposited 2023-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–359（313 aa）
Chain B
47–359（313 aa）
Chain C
47–359（313 aa）
Chain D
47–359（313 aa）
Chain E
47–359（313 aa）
|
Not recorded | PLC DIUNDECYL PHOSPHATIDYL CHOLINE × 25 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.42 Å |
| 8I42 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 7.5 Deposited 2023-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |
| 8I47 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 5.5 Deposited 2023-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 30 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 5.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.70 Å |
| 8I48 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in closed state Deposited 2023-01-18 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |
| 8JJ3 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 2.5 Deposited 2023-05-29 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 45 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.65 Å |
| 8WCQ Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in intermediate state Deposited 2023-09-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 40 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.35 Å |
| 8WCR Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state Deposited 2023-09-13 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 45 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.74 Å |
| 9LAG Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiiii conformation Deposited 2025-01-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 30 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.96 Å |
| 9LAI Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiiio conformation Deposited 2025-01-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 24 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.08 Å |
| 9LAJ Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiioo conformation Deposited 2025-01-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 23 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 9LAK Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iiooo conformation Deposited 2025-01-02 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 3 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 19 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.21 Å |
| 9LB9 Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ioooo conformation Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 22 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.16 Å |
| 9LBA Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ooooo conformation Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 35 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.85 Å |
| 9LBB Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in iioio conformation Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 10 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.45 Å |
| 9LBC Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in ioioo conformation Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Not recorded | PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 5 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.40 Å |
| 9LBD Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC F116A mutant at pH 2.5 Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Mutation：F116A Mutation：F116A Mutation：F116A Mutation：F116A Mutation：F116A | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 25 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.14 Å |
| 9LBE Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC Y251A mutant at pH 2.5 in ioooo conformation Deposited 2025-01-03 | Assembly 1 Protein homooligomer Homooligomer；Protein × 5 PDB declaration: pentameric（5） Consistent with protein count |
Chain A
47–358（312 aa）
Chain B
47–358（312 aa）
Chain C
47–358（312 aa）
Chain D
47–358（312 aa）
Chain E
47–358（312 aa）
|
Mutation：Y251 Mutation：Y251 Mutation：Y251 Mutation：Y251 Mutation：Y251 | CL CHLORIDE ION × 5 PEE 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine × 21 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 2.5
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.87 Å |