Current Protein Identity：Q8IJP3
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Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 9YRU Crystal structure of Apo Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum (Orthrhombic P form) Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | ZN ZINC ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.9；291 K；Berkeley D7: 100mM potassium phosphate dibasic, 100 mM potassium chloride, 30% PEG 3350. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 4mM ATP added to the protein prior to screening but ligand is not bound likely due to high phosphate concentration in the crystallant. plate 20147 D7 drop 1 , Puck: PSL-0309, Cryo: direct
|
Resolution 3.06 Å R-free 0.288 |
| 9YRW Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | MLI MALONATE ION × 5 GSU O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE × 2 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM GSU in 3.4M sodium malonate. Liu-S-192 E1, Puck: PSL-0114, Cryo: direct from soaking solution
|
Resolution 2.03 Å R-free 0.200 |
| 9YRX Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with Cysteine Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | MLI MALONATE ION × 4 CYS CYSTEINE × 2 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM cysteine in 3.4M sodium malonate. Liu-S-192 E1, Puck: PSL-0201, Cryo: direct from soaking solution
|
Resolution 2.16 Å R-free 0.215 |
| 9YRZ Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with AMP Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | AMP ADENOSINE MONOPHOSPHATE × 4 MLI MALONATE ION × 5 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM AMP in 3.4M sodium malonate. Liu-S-192 E1, Puck: PSL-0203, Cryo: direct from soaking solution
|
Resolution 2.06 Å R-free 0.195 |
| 9YS0 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with ADP Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 4 MLI MALONATE ION × 5 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM ADP in 3.4M sodium malonate. Liu-S-192 E1, Puck: PSL-0205, Cryo: direct from soaking solution
|
Resolution 2.14 Å R-free 0.199 |
| 9YS1 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with AMP and Cysteine Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | CYS CYSTEINE × 2 AMP ADENOSINE MONOPHOSPHATE × 4 MLI MALONATE ION × 3 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM AMP and Cysteine in 3.4M sodium malonate. plate Liu-S-192 G5 Puck: PSL-0209, Cryo: direct from soaking solution
|
Resolution 2.34 Å R-free 0.215 |
| 9YS2 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with cysteinyl-AMP Deposited 2025-10-17 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | A1CYZ 5'-O-[(R)-{[(2R)-2-amino-3-sulfanylpropanoyl]oxy}(hydroxy)phosphoryl]adenosine × 2 ATP ADENOSINE-5'-TRIPHOSPHATE × 2 MLI MALONATE ION × 5 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 24 hour soak with 10 mM ATP and Cysteine in 3.4M sodium malonate. The cysteinyl-AMP intermediate formed during the soak. plate Liu-S-192 G6 Puck: PSL-0210, Cryo: direct from soaking solution
|
Resolution 2.22 Å R-free 0.205 |
| 9YT0 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with ADP (long soak) Deposited 2025-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | ADP ADENOSINE-5'-DIPHOSPHATE × 4 MLI MALONATE ION × 3 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 1 month soak with 10 mM ADP in 3.4M sodium malonate. plate Liu-S-192 H3 Puck: PSL-2013, Cryo: direct from soaking solution
|
Resolution 2.45 Å R-free 0.216 |
| 9YT2 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with ATP (long soak) Deposited 2025-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | ATP ADENOSINE-5'-TRIPHOSPHATE × 4 MLI MALONATE ION × 3 ZN ZINC ION × 2 NA SODIUM ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 1 month soak with 10 mM ATP in 3.4M sodium malonate. plate Liu-S-192 H3 Puck: PSL-2014, Cryo: direct from soaking solution
|
Resolution 2.80 Å R-free 0.225 |
| 9YT3 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with 5'-Sulfamoyladenosine Deposited 2025-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | LMS [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE × 3 ZN ZINC ION × 2 NA SODIUM ION × 4 CL CHLORIDE ION × 24 MLI MALONATE ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 7 day soak with 10 mM LMS in 3.4M sodium malonate. plate Liu-S-192 G8 Puck: PSL-2103, Cryo: direct from soaking solution
|
Resolution 2.77 Å R-free 0.234 |
| 9YT5 Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum in complex with GMP Deposited 2025-10-20 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | 5GP GUANOSINE-5'-MONOPHOSPHATE × 4 MLI MALONATE ION × 3 ZN ZINC ION × 2 NA SODIUM ION × 2 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. 7 day soak with 10 mM GMP in 3.4M sodium malonate. plate Liu-S-192 H7 Puck: PSL-2106, Cryo: direct from soaking solution
|
Resolution 2.90 Å R-free 0.215 |
| 9Z4D Crystal structure of Cysteinyl-tRNA synthetase (CysRS) from Plasmodium falciparum (Hexagonal P form) Deposited 2025-11-10 | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric（2） Consistent with protein count |
Chain A
91–535（445 aa）
Fragment：residues 91-535
Chain B
91–535（445 aa）
Fragment：residues 91-535
|
Not recorded | ZN ZINC ION × 2 NA SODIUM ION × 2 CL CHLORIDE ION × 4 | X-RAY DIFFRACTION |
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；291 K；1.53M Sodium Malonate, pH 7.0. PlfaA.00133.a.A3.PS38777 at 12.3 mg/mL. Crystals were obtained as the GSU complex and soaked for 2 weeks with 10 mM Histidine in cryoprotectant. This displaced the GSU ligand resulting in an apo structure. Histidine was not bound. plate Liu-S-192 H8 , Puck: PSL-0115, Cryo: 3.4M sodium malonate
|
Resolution 2.87 Å R-free 0.236 |