Current Protein Identity：Q96RN5
New Search
Difference tags compare only the current result set; every original PDB and assembly record remains separate.
Related-Structure Differences
Each row represents one biological assembly in one PDB entry; multiple monomers of the same protein are listed separately.
| PDB Entry | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Experimental Method | Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 2GUT Solution structure of the trans-activation domain of the human co-activator ARC105 Deposited 2006-05-01 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
5–78（74 aa）
Fragment：ARC/MEDIATOR KIX domain, residues 5-78
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 6.8；298 K；Ionic strength (raw mmCIF value) 30 mM NaCl；Pressure ambient
NMR sample composition
1mM arc105 U-15N, 13C, 30mM NaCl, 10mM phosphate buffer, 90% H2O, 10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 7EMF Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation Deposited 2021-04-13 | Assembly 1 Protein heterocomplex Heteromer；Protein × 27 PDB declaration: 27-meric（27） Consistent with protein count |
Chain O
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.50 Å |
| 7ENA TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) Deposited 2021-04-16 | Assembly 1 Protein–DNA Heteromer；Protein × 74 PDB declaration: 76-meric（76） Consistent with all polymers |
Chain o
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 16 MG MAGNESIUM ION × 1 SF4 IRON/SULFUR CLUSTER × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.07 Å |
| 7ENC TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) Deposited 2021-04-16 | Assembly 1 Protein–DNA Heteromer；Protein × 74 PDB declaration: 76-meric（76） Consistent with all polymers |
Chain o
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 16 SF4 IRON/SULFUR CLUSTER × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.13 Å |
| 7ENJ Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) Deposited 2021-04-17 | Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric（26） Consistent with protein count |
Chain O
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 8
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.40 Å |
| 7LBM Structure of the human Mediator-bound transcription pre-initiation complex Deposited 2021-01-08 | Assembly 1 Protein–DNA Heteromer；Protein × 54 PDB declaration: 56-meric（56） Consistent with all polymers |
Chain z
1–788（788 aa）
|
Not recorded | MG MAGNESIUM ION × 2 ZN ZINC ION × 16 SF4 IRON/SULFUR CLUSTER × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.80 Å |
| 8GXQ PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state Deposited 2022-09-21 | Assembly 1 Protein–DNA Heteromer；Protein × 83 PDB declaration: 87-meric（87） Consistent with all polymers |
Chain o
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 19 SF4 IRON/SULFUR CLUSTER × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 5.04 Å |
| 8GXS PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state Deposited 2022-09-21 | Assembly 1 Protein–DNA Heteromer；Protein × 83 PDB declaration: 87-meric（87） Consistent with all polymers |
Chain o
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 19 SF4 IRON/SULFUR CLUSTER × 1 MG MAGNESIUM ION × 1 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.16 Å |
| 8J9A Solution structure of ABD3 (residues 453-561) of human MED15 isoform 2 Deposited 2023-05-03 | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric（1） Consistent with protein count |
Chain A
453–561（109 aa）
Fragment：activator-binding domain 3
|
Not recorded | No recorded non-water small molecule | SOLUTION NMR |
NMR measurement conditions
pH 7.5；298 K；Ionic strength (raw mmCIF value) 200；Pressure 1
NMR sample composition
1 mM [U-99% 13C; U-99% 15N] MED15_ABD3, 20 mM HEPES, 200 mM sodium chloride, 1 mM TCEP, 6 % v/v D2O, 94% H2O/6% D2O | 94% H2O/6% D2O
|
Resolution not provided |
| 8T9D CryoEM structure of TR-TRAP Deposited 2023-06-23 | Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric（26） Consistent with protein count |
Chain J
1–788（788 aa）
|
Not recorded | No recorded non-water small molecule | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.66 Å |
| 8TQW Structure of human transcriptional Mediator complex Deposited 2023-08-08 | Assembly 1 Protein heterocomplex Heteromer；Protein × 29 PDB declaration: 29-meric（29） Consistent with protein count |
Chain O
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 4 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 8.20 Å |
| 8TRH The IDRc bound human core Mediator complex Deposited 2023-08-09 | Assembly 1 Protein heterocomplex Heteromer；Protein × 26 PDB declaration: 26-meric（26） Consistent with protein count |
Chain O
1–788（788 aa）
|
Not recorded | ZN ZINC ION × 2 | ELECTRON MICROSCOPY |
cryo-EM buffer
pH 7.9
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.70 Å |