8trh

The IDRc bound human core Mediator complex

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Mediator of RNA polymerase II transcription subunit 27

OrganismNot specified

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED27_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 0； PDBConstruct 1–311； UniProt 1–311

Mediator of RNA polymerase II transcription subunit 28

OrganismNot specified

UniProt Q9H204

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED28_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 1； PDBConstruct 1–178； UniProt 1–178

Mediator of RNA polymerase II transcription subunit 29

OrganismNot specified

UniProt Q9NX70

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED29_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 2； PDBConstruct 1–200； UniProt 1–200

Mediator of RNA polymerase II transcription subunit 30

OrganismNot specified

UniProt Q96HR3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED30_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 3； PDBConstruct 1–178； UniProt 1–178

Mediator of RNA polymerase II transcription subunit 31

OrganismNot specified

UniProt Q9Y3C7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED31_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 4； PDBConstruct 1–131； UniProt 1–131

Mediator of RNA polymerase II transcription subunit 1

OrganismNot specified

UniProt Q15648

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED1_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain A； PDBConstruct 1–1581； UniProt 1–1581

Mediator of RNA polymerase II transcription subunit 4

OrganismNot specified

UniProt Q9NPJ6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED4_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain D； PDBConstruct 1–270； UniProt 1–270

Mediator of RNA polymerase II transcription subunit 6

OrganismNot specified

UniProt O75586

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED6_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain F； PDBConstruct 1–246； UniProt 1–246

Mediator of RNA polymerase II transcription subunit 7

OrganismNot specified

UniProt O43513

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED7_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain G； PDBConstruct 1–233； UniProt 1–233

Mediator of RNA polymerase II transcription subunit 8

OrganismNot specified

UniProt Q96G25

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED8_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain H； PDBConstruct 1–268； UniProt 1–268

Mediator of RNA polymerase II transcription subunit 9

OrganismNot specified

UniProt Q9NWA0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED9_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain I； PDBConstruct 1–146； UniProt 1–146

Mediator of RNA polymerase II transcription subunit 10

OrganismNot specified

UniProt Q9BTT4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED10_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain J； PDBConstruct 1–135； UniProt 1–135

Mediator of RNA polymerase II transcription subunit 11

OrganismNot specified

UniProt Q9P086

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED11_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain K； PDBConstruct 1–117； UniProt 1–117

Mediator of RNA polymerase II transcription subunit 14

OrganismNot specified

UniProt O60244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED14_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain N； PDBConstruct 1–1454； UniProt 1–1454

Mediator of RNA polymerase II transcription subunit 15

OrganismNot specified

UniProt Q96RN5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED15_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain O； PDBConstruct 1–788； UniProt 1–788

Mediator of RNA polymerase II transcription subunit 16

OrganismNot specified

UniProt Q9Y2X0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED16_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain P； PDBConstruct 1–877； UniProt 1–877

Mediator of RNA polymerase II transcription subunit 17

OrganismNot specified

UniProt Q9NVC6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED17_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain Q； PDBConstruct 1–651； UniProt 1–651

Mediator of RNA polymerase II transcription subunit 18

OrganismNot specified

UniProt Q9BUE0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED18_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain R； PDBConstruct 1–208； UniProt 1–208

Mediator of RNA polymerase II transcription subunit 20

OrganismNot specified

UniProt Q9H944

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED20_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain T； PDBConstruct 1–212； UniProt 1–212

Mediator of RNA polymerase II transcription subunit 22

OrganismNot specified

UniProt Q15528

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED22_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain V； PDBConstruct 1–200； UniProt 1–200

Mediator of RNA polymerase II transcription subunit 23

OrganismNot specified

UniProt Q9ULK4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED23_HUMAN
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain W； PDBConstruct 1–1368； UniProt 1–1368

Mediator of RNA polymerase II transcription subunit 24

OrganismNot specified

UniProt O75448

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED24_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain X； PDBConstruct 1–989； UniProt 1–989

Mediator of RNA polymerase II transcription subunit 13

OrganismNot specified

UniProt Q9UHV7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED13_HUMAN
Isoform	—
PDB entities	24
Chains and sequence ranges	Author chain d； PDBConstruct 1–2174； UniProt 1–2174

Mediator of RNA polymerase II transcription subunit 19

OrganismNot specified

UniProt A0JLT2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED19_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain S； PDBConstruct 1–244； UniProt 1–244

Mediator of RNA polymerase II transcription subunit 21

OrganismNot specified

UniProt Q13503

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein heterocomplex	Heteromer	Protein 26	Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） Mediator of RNA polymerase II transcription subunit 29 × 1 （Q9NX70） Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 1 × 1 （Q15648） Unknown Chain × 1 Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 15 × 1 （Q96RN5） Mediator of RNA polymerase II transcription subunit 16 × 1 （Q9Y2X0） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 23 × 1 （Q9ULK4） Mediator of RNA polymerase II transcription subunit 24 × 1 （O75448） Mediator of RNA polymerase II transcription subunit 13 × 1 （Q9UHV7） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） ZINC ION × 2	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED21_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain U； PDBConstruct 1–144； UniProt 1–144

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8trh
Deposition date deposition_date	2023-08-09
Structure title title	The IDRc bound human core Mediator complex
Keywords keywords	Transcription, Mediator.; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8trh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8trh__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8trh__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	99.94 Å
Rg (electron density)	102.10 Å
Total Rg	101.50 Å
Atom count	59957
Residues	7623
Excluded volume	1073300 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8trh__assembly_1__model_1`	26-meric （26）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (27)

Entity 1 Entity 1 polymer

Description description	Mediator of RNA polymerase II transcription subunit 27
Molecular weight formula_weight	35478.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	0
Atom count atom_count	59957

MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ

Entity 2 Entity 2 polymer

Description description	Mediator of RNA polymerase II transcription subunit 28
Molecular weight formula_weight	19540.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1

MAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQASANIPAPLKPT

Entity 3 Entity 3 polymer

Description description	Mediator of RNA polymerase II transcription subunit 29
Molecular weight formula_weight	21089.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2

MAASQQQASAASSAAGVSGPSSAGGPGPQQQPQPPAQLVGPAQSGLLQQQQQDFDPVQRYKMLIPQLKESLQTLMKVAAQNLIQNTNIDNGQKSSDGPIQRFDKCLEEFYALCDQLELCLRLAHECLSQSCDSAKHSPTLVPTATKPDAVQPDSLPYPQYLAVIKAQISCAKDIHTALLDCANKVTGKTPAPPAGPGGTL

Entity 4 Entity 4 polymer

Description description	Mediator of RNA polymerase II transcription subunit 30
Molecular weight formula_weight	20301.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MSTPPLAASGMAPGPFAGPQAQQAAREVNTASLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDNLRQLSVLFRKLRLVYDKCNENCGGMDPIPVEQLIPYVEEDGSKNDDRAGPPRFASEERREIAEVNKKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN

Entity 5 Entity 5 polymer

Description description	Mediator of RNA polymerase II transcription subunit 31
Molecular weight formula_weight	15826.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK

Entity 6 Entity 6 polymer

Description description	Mediator of RNA polymerase II transcription subunit 1
Molecular weight formula_weight	168697.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPIILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTTGDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN

Entity 7 Entity 7 polymer

Description description	Unknown Chain
Molecular weight formula_weight	1720.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

XXXXXXXXXXXXXXXXXXXX

Entity 8 Entity 8 polymer

Description description	Mediator of RNA polymerase II transcription subunit 4
Molecular weight formula_weight	29781.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD

Entity 9 Entity 9 polymer

Description description	Mediator of RNA polymerase II transcription subunit 6
Molecular weight formula_weight	28464.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ

Entity 10 Entity 10 polymer

Description description	Mediator of RNA polymerase II transcription subunit 7
Molecular weight formula_weight	27285.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP

Entity 11 Entity 11 polymer

Description description	Mediator of RNA polymerase II transcription subunit 8
Molecular weight formula_weight	29112.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR

Entity 12 Entity 12 polymer

Description description	Mediator of RNA polymerase II transcription subunit 9
Molecular weight formula_weight	16422.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MASAGVAAGRQAEDVLPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREEENYSFLPLVHNIIKCMDKDSPEVHQDLNALKSKFQEMRKLISTMPGIHLSPEQQQQQLQSLREQVRTKNELLQKYKSLCMFEIPKE

Entity 13 Entity 13 polymer

Description description	Mediator of RNA polymerase II transcription subunit 10
Molecular weight formula_weight	15711.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS

Entity 14 Entity 14 polymer

Description description	Mediator of RNA polymerase II transcription subunit 11
Molecular weight formula_weight	13145.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN

Entity 15 Entity 15 polymer

Description description	Mediator of RNA polymerase II transcription subunit 14
Molecular weight formula_weight	160787.6 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP

Entity 16 Entity 16 polymer

Description description	Mediator of RNA polymerase II transcription subunit 15
Molecular weight formula_weight	86830.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA

Entity 17 Entity 17 polymer

Description description	Mediator of RNA polymerase II transcription subunit 16
Molecular weight formula_weight	96908.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLAVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP

Entity 18 Entity 18 polymer

Description description	Mediator of RNA polymerase II transcription subunit 17
Molecular weight formula_weight	72984.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL

Entity 19 Entity 19 polymer

Description description	Mediator of RNA polymerase II transcription subunit 18
Molecular weight formula_weight	23693.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRLM

Entity 20 Entity 20 polymer

Description description	Mediator of RNA polymerase II transcription subunit 20
Molecular weight formula_weight	23243.8 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRHDAVYGPADTMVQYMELFNKIRKQQQVPVAGIR

Entity 21 Entity 21 polymer

Description description	Mediator of RNA polymerase II transcription subunit 22
Molecular weight formula_weight	22243.7 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA

Entity 22 Entity 22 polymer

Description description	Mediator of RNA polymerase II transcription subunit 23
Molecular weight formula_weight	156652.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ

Entity 23 Entity 23 polymer

Description description	Mediator of RNA polymerase II transcription subunit 24
Molecular weight formula_weight	110430.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKLKKYSHGDKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECGKQGLLSEASVNNLMAKRKADREHAPQQKSGENANIQPNIQLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTYGSEESTKPASVRALLFDISFLMLCHVAQTYGSEVILSESRTGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLFSENTLQFYNERVVIMNSILERMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHIFDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASTRQKKRHREDIEDYISLFPLDDVQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVDCLEQGGRGSVLQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL

Entity 24 Entity 24 polymer

Description description	Mediator of RNA polymerase II transcription subunit 13
Molecular weight formula_weight	239535.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

MSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPSFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSVQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEATAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKFPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQCLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGSDDKASCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGPSMPFIKEGDGSNMDQEYGTAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRATSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTVTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENTDESTNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML

Entity 25 Entity 25 polymer

Description description	Mediator of RNA polymerase II transcription subunit 19
Molecular weight formula_weight	26321.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

MENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR

Entity 26 Entity 26 polymer

Description description	Mediator of RNA polymerase II transcription subunit 21
Molecular weight formula_weight	15575.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS

Entity 27 Entity 27 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	2

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.70 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	97904

The IDRc bound human core Mediator complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

Mediator of RNA polymerase II transcription subunit 27

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 28

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 29

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 30

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 31

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Mediator of RNA polymerase II transcription subunit 8

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer