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1agr

COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)

Rattus norvegicus

UniProt P10824

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 RGS4 × 1 （P49799） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 RGS4 × 1 （P49799） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1as0 1as2 1as3 1bh2 1bof 1cip 1gdd 1gfi 1gia 1gil 1git 1svk

26 assemblies; showing the first 12

Homodimer
2zjz

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1agr 1agr 1fqj 1fqj 1fqk 1fqk 1gg2 1gp2 1shz 1shz 1shz 2bcj

31 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GBI1_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–353； UniProt 1–353 Author chain D； PDBConstruct 1–353； UniProt 1–353

RGS4

Rattus norvegicus

UniProt P49799

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) × 1 （P10824） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) × 1 （P10824） MAGNESIUM ION × 1 TETRAFLUOROALUMINATE ION × 1 GUANOSINE-5'-DIPHOSPHATE × 1 CITRIC ACID × 1 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1ezt 1ezy

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1agr 1agr

2 assemblies

View Construct and Data Evidence
UniProt name RGS4_RAT
Isoform —
PDB entities 2
Chains and sequence ranges Author chain E； PDBConstruct 1–205； UniProt 1–205 Author chain H； PDBConstruct 1–205； UniProt 1–205

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1agr
Deposition date deposition_date1997-03-25
Structure title titleCOMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
Keywords keywords;GI-ALPHA-1, HYDROLASE, SIGNAL TRANSDUCTION, RGS4, COMPLEX (SIGNAL TRANSDUCTION-REGULATOR), GTP-BINDING, GTPASE ACTIVATING PROTEIN, COMPLEX (SIGNAL TRANSDUCTION-REGULATOR) complex ;; COMPLEX (SIGNAL TRANSDUCTION/REGULATOR)
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1agr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1agr__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1agr__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.56 Å
Rg (electron density)24.94 Å
Total Rg25.69 Å
Atom count3909
Residues478
Excluded volume69543 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1agr__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1agr__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

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6. Fold Classification (SCOP + CATH) 14 domains

SCOP 2.08 (6 domains)

Domain ID domain_idd1agra1
Class classa — All alpha proteins
Fold Fold folda.66 — Transducin (alpha subunit), insertion domain
Superfamily Superfamily superfamilya.66.1 — Transducin (alpha subunit), insertion domain
Family Family familya.66.1.1 — Transducin (alpha subunit), insertion domain
Domain ID domain_idd1agra2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1agrd1
Class classa — All alpha proteins
Fold Fold folda.66 — Transducin (alpha subunit), insertion domain
Superfamily Superfamily superfamilya.66.1 — Transducin (alpha subunit), insertion domain
Family Family familya.66.1.1 — Transducin (alpha subunit), insertion domain
Domain ID domain_idd1agrd2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1agre_
Class classa — All alpha proteins
Fold Fold folda.91 — Regulator of G-protein signaling, RGS
Superfamily Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
Family Family familya.91.1.1 — Regulator of G-protein signaling, RGS
Domain ID domain_idd1agrh_
Class classa — All alpha proteins
Fold Fold folda.91 — Regulator of G-protein signaling, RGS
Superfamily Superfamily superfamilya.91.1 — Regulator of G-protein signaling, RGS
Family Family familya.91.1.1 — Regulator of G-protein signaling, RGS

CATH v4.4 (8 domains)

Domain ID domain_id1agrA01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1agrA02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id1agrD01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1agrD02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology400 — GI Alpha 1, domain 2-like
Homologous superfamily homologous superfamily10 — GI Alpha 1, domain 2-like
Domain ID domain_id1agrE01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology196 — Regulator of G-protein Signalling 4; domain 1
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1agrE02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology167 — Regulator of G-protein Signalling 4; domain 2
Homologous superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
Domain ID domain_id1agrH01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology196 — Regulator of G-protein Signalling 4; domain 1
Homologous superfamily homologous superfamily10 —
Domain ID domain_id1agrH02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology167 — Regulator of G-protein Signalling 4; domain 2
Homologous superfamily homologous superfamily10 — Regulator of G-protein Signalling 4, domain 2
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7. Citations (1)