← Back to search

1b6a

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470

Method: X-RAY DIFFRACTION D_max: 67.1 Å Quality: GOOD

SAXS Profile

P(r) Distribution

▼

1. Structure Basics

entry_id	1b6a
deposition_date	1999-01-13
title	HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470
keywords	ANGIOGENESIS INHIBITOR, AMINOPEPTIDASE; ANGIOGENESIS INHIBITOR
method	X-RAY DIFFRACTION

▼

Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

▼

2. SAXS Parameters (CRYSOL)

rg_guinier	21.00 Å
rg_electron	20.05 Å
i0	28597400.00
molecular_weight	40285.0 kDa
excluded_volume	50109 Å³
envelope_volume	57454 Å³
shell_volume	23292 Å³
envelope_diameter	71.4 Å
shell_rg	27.35 Å
envelope_rg	20.69 Å
shape_rg	20.04 Å
total_rg	20.99 Å
total_atoms	2815
n_residues	355
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

▼

3. P(r) Analysis (GNOM)

dmax	67.1 Å
rg_real	20.88 Å
rg_real_error	0.34 Å
i0_real	2.8600e+07
i0_real_error	3.6720e+05
rg_reciprocal	20.91 Å
i0_reciprocal	28600000.0000
total_estimate	0.8942
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	26.3 Å
skewness	0.184
kurtosis	-0.432
angular_range	— – 0.3800 Å⁻¹
current_alpha	0.0000
highest_alpha	10780000.0000
n_real_points	70
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.877; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.996; Smooth: 0.992

▶

4. Crystallography & Experiment

▶

5. Entities & Polymer Info (4)

Entity 1 polymer

description	METHIONINE AMINOPEPTIDASE
formula_weight	52971.5 kDa
ec_number	3.4.11.18
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3028

MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda MNPV

Entity 2 non-polymer

description	COBALT (II) ION
formula_weight	58.9 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	;(1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate ;
formula_weight	403.9 kDa
src_method	syn
entity_count	1

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	213

▶

6. Citations (1)

▶

length_a	89.558 Å
length_b	99.060 Å
length_c	101.508 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 2 2 21
int_tables_number	20
crystal_system	—

resolution	1.600 Å
resolution_low	6.000 Å
r_factor	0.1870
r_work	0.1870
r_free	0.2160

fit	/app/data/saxs_computation/b6/1b6a/1b6a.fit
pddf	/app/data/pr_computation/b6/1b6a/1b6a.pr.out
profile	/app/data/saxs_computation/b6/1b6a/1b6a.dat

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction