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1boa

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN

Method: X-RAY DIFFRACTION D_max: 66.2 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1boa
deposition_date	1998-08-01
title	HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN
keywords	METHIONINE AMINOPEPTIDASE, ANGIOGENESIS INHIBITOR, FUMAGILLIN, HYDROLASE, AMINOPEPTIDASE; AMINOPEPTIDASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	20.97 Å
rg_electron	20.02 Å
i0	27911500.00
molecular_weight	40007.0 kDa
excluded_volume	49855 Å³
envelope_volume	57324 Å³
shell_volume	23324 Å³
envelope_diameter	69.8 Å
shell_rg	27.22 Å
envelope_rg	20.51 Å
shape_rg	20.01 Å
total_rg	20.95 Å
total_atoms	2798
n_residues	354
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	66.2 Å
rg_real	20.84 Å
rg_real_error	0.28 Å
i0_real	2.7910e+07
i0_real_error	3.1930e+05
rg_reciprocal	20.87 Å
i0_reciprocal	27910000.0000
total_estimate	0.8955
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	25.9 Å
skewness	0.156
kurtosis	-0.471
angular_range	— – 0.3800 Å⁻¹
current_alpha	0.0000
highest_alpha	9934000.0000
n_real_points	70
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.894; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.993; Smooth: 0.961

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	METHIONINE AMINOPEPTIDASE
formula_weight	52985.6 kDa
ec_number	3.4.11.18
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	3008

MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIIKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Spodoptera frugiperda

Entity 2 non-polymer

description	COBALT (II) ION
formula_weight	58.9 kDa
src_method	syn
entity_count	2

Entity 3 non-polymer

description	FUMAGILLIN
formula_weight	460.6 kDa
src_method	syn
entity_count	1

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	204

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6. Citations (1)

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length_a	90.700 Å
length_b	99.580 Å
length_c	101.950 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	8

space_group	C 2 2 21
int_tables_number	20
crystal_system	—

resolution	1.800 Å
resolution_low	25.000 Å
r_factor	—
r_work	0.1930
r_free	0.2320

fit	/app/data/saxs_computation/bo/1boa/1boa.fit
pddf	/app/data/pr_computation/bo/1boa/1boa.pr.out
profile	/app/data/saxs_computation/bo/1boa/1boa.dat

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction