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1cwr

HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE

Method: X-RAY DIFFRACTION D_max: 56.6 Å Quality: GOOD

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	1cwr
deposition_date	1999-08-26
title	HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE
keywords	HYDROLASE, CELL CYCLE PHOSPHATASE, DUAL SPECIFICITY PROTEIN PHOSPHATASE, CDC25, CDC25B; HYDROLASE
method	X-RAY DIFFRACTION

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	17.52 Å
rg_electron	16.33 Å
i0	8154830.00
molecular_weight	21101.0 kDa
excluded_volume	26456 Å³
envelope_volume	30022 Å³
shell_volume	15522 Å³
envelope_diameter	57.2 Å
shell_rg	22.34 Å
envelope_rg	16.68 Å
shape_rg	16.35 Å
total_rg	17.31 Å
total_atoms	1485
n_residues	178
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	56.6 Å
rg_real	17.43 Å
rg_real_error	0.33 Å
i0_real	8.1550e+06
i0_real_error	9.7080e+04
rg_reciprocal	17.44 Å
i0_reciprocal	8155000.0000
total_estimate	0.8106
solution_quality	GOOD a GOOD solution
n_peaks	3
r_peak_primary	22.6 Å
skewness	0.222
kurtosis	-0.302
angular_range	— – 0.4550 Å⁻¹
current_alpha	0.0000
highest_alpha	2040000.0000
n_real_points	76
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.845; Stabil: 0.999; Sysdev: 1.000; Positv: 1.000; Valcen: 1.000; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (4)

Entity 1 polymer

description	PROTEIN (M-PHASE INDUCER PHOSPHATASE 2 (CDC25B))
formula_weight	24907.5 kDa
ec_number	3.1.3.48
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	1596

VLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Escherichia coli

Entity 2 non-polymer

description	SULFATE ION
formula_weight	96.1 kDa
src_method	syn
entity_count	1

Entity 3 non-polymer

description	BETA-MERCAPTOETHANOL
formula_weight	78.1 kDa
src_method	syn
entity_count	1

Entity 4 water

description	water
formula_weight	18.0 kDa
src_method	nat
entity_count	103

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6. Citations (1)

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length_a	51.733 Å
length_b	71.110 Å
length_c	75.247 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	4

space_group	P 21 21 21
int_tables_number	19
crystal_system	—

resolution	2.100 Å
resolution_low	10.000 Å
r_factor	0.2040
r_work	—
r_free	—

fit	/app/data/saxs_computation/cw/1cwr/1cwr.fit
pddf	/app/data/pr_computation/cw/1cwr/1cwr.pr.out
profile	/app/data/saxs_computation/cw/1cwr/1cwr.dat

HUMAN CDC25B CATALYTIC DOMAIN WITHOUT ION IN CATALYTIC SITE

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

Diffraction