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1jt6

Crystal structure of the multidrug binding protein QacR bound to dequalinium

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

;Hypothetical transcriptional regulator IN QACA 5'region ;

Staphylococcus aureus

UniProt P0A0N4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 15 DEQUALINIUM × 1 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 SULFATE ION × 13 water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1jt6 1jt6 1jtx 1jtx 1jty 1jty 1jum 1jum 1jup 1jup 1jus 1jus

26 assemblies; showing the first 12

Homotetramer
1qvu

1 assemblies

Other homooligomers
2gby 2gby

2 assemblies

Heteromeric or nucleic-acid complex
1jt0

1 assemblies

View Construct and Data Evidence
UniProt name QACR_STAAU
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–188； UniProt 1–188 Author chain B； PDBConstruct 1–188； UniProt 1–188 Author chain D； PDBConstruct 1–188； UniProt 1–188 Author chain E； PDBConstruct 1–188； UniProt 1–188

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1jt6
Deposition date deposition_date2001-08-20
Structure title titleCrystal structure of the multidrug binding protein QacR bound to dequalinium
Keywords keywordsmutlidrug binding recognition, QacR, Mulitdrug resistance, S. aureus, TRANSCRIPTION; TRANSCRIPTION
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1jt6__assembly_2__model_1

Assembly 2 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1jt6__assembly_2__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1jt6__assembly_2__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）22.81 Å
Rg (electron density)21.69 Å
Total Rg22.77 Å
Atom count3159
Residues372
Excluded volume56152 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1jt6__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1jt6__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 16 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1jt6a1
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.1 — Homeodomain-like
Family Family familya.4.1.9 — Tetracyclin repressor-like, N-terminal domain
Domain ID domain_idd1jt6a2
Class classa — All alpha proteins
Fold Fold folda.121 — Tetracyclin repressor-like, C-terminal domain
Superfamily Superfamily superfamilya.121.1 — Tetracyclin repressor-like, C-terminal domain
Family Family familya.121.1.1 — Tetracyclin repressor-like, C-terminal domain
Domain ID domain_idd1jt6b1
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.1 — Homeodomain-like
Family Family familya.4.1.9 — Tetracyclin repressor-like, N-terminal domain
Domain ID domain_idd1jt6b2
Class classa — All alpha proteins
Fold Fold folda.121 — Tetracyclin repressor-like, C-terminal domain
Superfamily Superfamily superfamilya.121.1 — Tetracyclin repressor-like, C-terminal domain
Family Family familya.121.1.1 — Tetracyclin repressor-like, C-terminal domain
Domain ID domain_idd1jt6d1
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.1 — Homeodomain-like
Family Family familya.4.1.9 — Tetracyclin repressor-like, N-terminal domain
Domain ID domain_idd1jt6d2
Class classa — All alpha proteins
Fold Fold folda.121 — Tetracyclin repressor-like, C-terminal domain
Superfamily Superfamily superfamilya.121.1 — Tetracyclin repressor-like, C-terminal domain
Family Family familya.121.1.1 — Tetracyclin repressor-like, C-terminal domain
Domain ID domain_idd1jt6e1
Class classa — All alpha proteins
Fold Fold folda.4 — DNA/RNA-binding 3-helical bundle
Superfamily Superfamily superfamilya.4.1 — Homeodomain-like
Family Family familya.4.1.9 — Tetracyclin repressor-like, N-terminal domain
Domain ID domain_idd1jt6e2
Class classa — All alpha proteins
Fold Fold folda.121 — Tetracyclin repressor-like, C-terminal domain
Superfamily Superfamily superfamilya.121.1 — Tetracyclin repressor-like, C-terminal domain
Family Family familya.121.1.1 — Tetracyclin repressor-like, C-terminal domain

CATH v4.4 (8 domains)

Domain ID domain_id1jt6A01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id1jt6A02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily10 — Tetracycline Repressor, domain 2
Domain ID domain_id1jt6B01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id1jt6B02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily10 — Tetracycline Repressor, domain 2
Domain ID domain_id1jt6D01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id1jt6D02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily10 — Tetracycline Repressor, domain 2
Domain ID domain_id1jt6E01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology10 — Arc Repressor Mutant, subunit A
Homologous superfamily homologous superfamily60 — Homeodomain-like
Domain ID domain_id1jt6E02
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology357 — Tetracycline Repressor; domain 2
Homologous superfamily homologous superfamily10 — Tetracycline Repressor, domain 2
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7. Citations (1)