Superoxide dismutase [Cu-Zn]
Homo sapiens
State in the Current Structure
| Assembly | Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Associated Components | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|
| 1 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain A； UniProt 1–153 Chain B； UniProt 1–153 | Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.70 Å R-free 0.243 |
| 2 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain C； UniProt 1–153 Chain D； UniProt 1–153 | Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.70 Å R-free 0.243 |
| 3 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain E； UniProt 1–153 Chain F； UniProt 1–153 | Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.70 Å R-free 0.243 |
| 4 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain G； UniProt 1–153 Chain H； UniProt 1–153 | Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.70 Å R-free 0.243 |
| 5 | Protein homooligomer Homooligomer Protein × 2 PDB declaration: dimeric（2） Consistent with protein copy count | Chain I； UniProt 1–153 Chain J； UniProt 1–153 | Not recorded | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 | X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K | Resolution 1.70 Å R-free 0.243 |
Other States of the Same Protein in the Database
Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.
| Other PDB | Difference from Current Entry 1PU0 | Assembly / Oligomeric State | Construct | Mutations and Modifications | Ligands, Ions and Non-polymers | Method and Experimental Conditions | Structure Quality |
|---|---|---|---|---|---|---|---|
| 1AZV FAMILIAL ALS MUTANT G37R CUZNSOD (HUMAN) Deposited 1997-11-21 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：G37R Mutation：G37R | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5.5；20 MG/ML PROTEIN IN 10MM ACETATE PH 5.5 MIXED WITH PRECIPITATING SOLUTION OF 100 MM ACETATE PH 4.6, 2.0 M AMMONIUM SULFATE
|
Resolution 1.90 Å R-free 0.244 |
| 1BA9 THE SOLUTION STRUCTURE OF REDUCED MONOMERIC SUPEROXIDE DISMUTASE, NMR, 36 STRUCTURES Deposited 1998-04-24 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | ZN ZINC ION × 1 CU1 COPPER (I) ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure 1
NMR sample composition
H2O AND D2O
|
Resolution not provided |
| 1DSW THE SOLUTION STRUCTURE OF A MONOMERIC, REDUCED FORM OF HUMAN COPPER, ZINC SUPEROXIDE DISMUTASE BEARING THE SAME CHARGE AS THE NATIVE PROTEIN Deposited 2000-01-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
Fragment：;M4SOD IS A MONOMERIC VARIANT OF HUMAN SOD. THE MUTANT IS STUDIED IN THE REDUCED FORM, EACH MOLECULE CONTAINS A CU(I) AND A ZN(II) IONS.
;
|
Mutation：YES | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure ATMOSPHERIC
NMR sample composition
2MM M4SOD FULLY ENRICHED IN 15N; 20MM PHOSPHATE BUFFER PH 5.0; 90% H2O, 10% D2O. THE PROTEIN WAS REDUCED WITH SODIUM ISOASCORBATE UNDER UNAEROBIC CONDITIONS.
|
Resolution not provided |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1FUN SUPEROXIDE DISMUTASE MUTANT WITH LYS 136 REPLACED BY GLU, CYS 6 REPLACED BY ALA AND CYS 111 REPLACED BY SER (K136E, C6A, C111S) Deposited 1998-07-23 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：C6A, C111S, K136E Mutation：C6A, C111S, K136E | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；pH 7.0
|
Resolution 2.85 Å |
| 1HL4 The Structure of Apo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NH4CL, 20%PEG2000, 10% ETHYLENE GLYCOL, 0.1 M MES PH 5.6
|
Resolution 1.82 Å R-free 0.283 |
| 1HL4 The Structure of Apo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NH4CL, 20%PEG2000, 10% ETHYLENE GLYCOL, 0.1 M MES PH 5.6
|
Resolution 1.82 Å R-free 0.283 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
2–154（153 aa）
Chain I
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain M
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain N
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
Chain Q
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1HL5 The Structure of Holo Type Human Cu, Zn Superoxide Dismutase Deposited 2003-03-13 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
Chain S
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2 M CA ACETATE, 15% PEG 3350, 0.1 M TRIS PH 8.0
|
Resolution 1.80 Å R-free 0.222 |
| 1KMG The Solution Structure Of Monomeric Copper-free Superoxide Dismutase Deposited 2001-12-15 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | ZN ZINC ION × 1 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 20 mM phosphate；Pressure 1
NMR sample composition
2mM of 15N and 13C enriched superoxide dismutase | 20mM phosphate buffer, 10% D20
NMR sample composition
2mM of 15N and 13C enriched superoxide dismutase | 20mM phosphate buffer, 10% D20
NMR sample composition
2mM unlabelled superoxide dismutase | 20mM phosphate buffer, 10% D20
|
Resolution not provided |
| 1L3N The Solution Structure of Reduced Dimeric Copper Zinc SOD: the Structural Effects of Dimerization Deposited 2002-02-28 | Different mutation/modification Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
SOLUTION NMR
NMR measurement conditions
pH 5；296 K；Pressure 1
NMR measurement conditions
pH 5；286 K；Pressure 1
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N, 13C | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N, 13C and 2H at 70% | 20mM phosphate buffer pH5.00
10% D2O, 8mM ascorbate reductant
NMR sample composition
Cu(I),Zn(II) SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.00
100% D2O, 8mM ascorbate reductant
|
Resolution not provided |
| 1MFM MONOMERIC HUMAN SOD MUTANT F50E/G51E/E133Q AT ATOMIC RESOLUTION Deposited 1999-04-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A,F50E,G51E,C111S,E133Q | ZN ZINC ION × 1 CU COPPER (II) ION × 1 CD CADMIUM ION × 9 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；PEG 6000 15%, CDCL2 200-400 MM, TRIS 100MM, PH=8, pH 8.0
|
Resolution 1.02 Å |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–153（154 aa）
Chain B
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
0–153（154 aa）
Chain D
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
0–153（154 aa）
Chain F
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
0–153（154 aa）
Chain H
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N18 Thermostable mutant of Human Superoxide Dismutase, C6A, C111S Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
0–153（154 aa）
Chain J
0–153（154 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；Ammonium Sulfate, NaCl, Tris, EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.00 Å R-free 0.250 |
| 1N19 Structure of the HSOD A4V mutant Deposited 2002-10-16 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
0–153（154 aa）
Chain B
0–153（154 aa）
|
Mutation：A4V, C6A, C111S Mutation：A4V, C6A, C111S | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；293 K；ammonium sulfate, NaCl, Tris, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 1.86 Å R-free 0.260 |
| 1OEZ Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase Deposited 2003-04-02 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Y
1–153（153 aa）
Chain Z
1–153（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NA2SO4, 15% PEG 3350, pH 8.00
|
Resolution 2.15 Å R-free 0.234 |
| 1OEZ Zn His46Arg mutant of Human Cu, Zn Superoxide Dismutase Deposited 2003-04-02 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain W
1–153（153 aa）
Chain X
1–153（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；0.2M NA2SO4, 15% PEG 3350, pH 8.00
|
Resolution 2.15 Å R-free 0.234 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
1–153（153 aa）
Chain N
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–153（153 aa）
Chain L
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZT Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution Deposited 2003-04-09 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：H46R Mutation：H46R | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；magnesium acetate, sodium cacodylate, PEG 8000, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
|
Resolution 2.50 Å R-free 0.270 |
| 1OZU Crystal Structure of Familial ALS Mutant S134N of human Cu,Zn Superoxide Dismutase (CuZnSOD) to 1.3A resolution Deposited 2003-04-09 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：S134N Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S134N Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 3 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；Ammonium sulfate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
|
Resolution 1.30 Å R-free 0.193 |
| 1P1V Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A Deposited 2003-04-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；zinc sulfate, PEG MME 550, MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 1.40 Å R-free 0.212 |
| 1P1V Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A Deposited 2003-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
|
Mutation：D125H Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；278 K；zinc sulfate, PEG MME 550, MES, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 278K
|
Resolution 1.40 Å R-free 0.212 |
| 1PTZ Crystal structure of the human CU, Zn Superoxide Dismutase, Familial Amyotrophic Lateral Sclerosis (FALS) Mutant H43R Deposited 2003-06-23 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S, H43R Mutation：C6A, C111S, H43R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；294 K；ammonium sulphate, sodium chloride, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
|
Resolution 1.80 Å R-free 0.215 |
| 1RK7 Solution structure of apo Cu,Zn Superoxide Dismutase: role of metal ions in protein folding Deposited 2003-11-21 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–153（153 aa）
|
Mutation：C6A, F50E, G51E, C111S, E133Q | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Pressure 1
NMR sample composition
Apo SOD 2mM | 20mM phosphate buffer pH5.0, 10% D2O
NMR sample composition
Apo SOD 2mM enriched in 15N | 20mM phosphate buffer pH5.0, 10% D2O
NMR sample composition
Apo SOD 2mM enriched in 15N and 13C | 20mM phosphate buffer pH5.0, 10% D2O
|
Resolution not provided |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SOS ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLE MUTANT RECOMBINANT HUMAN CU, ZN SUPEROXIDE DISMUTASE Deposited 1992-02-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.50 Å |
| 1SPD AMYOTROPHIC LATERAL SCLEROSIS AND STRUCTURAL DEFECTS IN CU,ZN SUPEROXIDE DISMUTASE Deposited 1993-07-21 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 | X-RAY DIFFRACTION mmCIF provides none of the parsed conditions | Resolution 2.40 Å |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXL I113T mutant of human SOD1 Deposited 2004-02-25 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；100 MM NACL, 2.4M AMMONIUM SULPHATE PH 7.5
|
Resolution 1.60 Å R-free 0.196 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 1UXM A4V mutant of human SOD1 Deposited 2004-02-26 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–153（153 aa）
Chain L
1–153（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；0.2 M CA ACET, 15% PEG 2000, 0.1 M TRIS PH 8.0
|
Resolution 1.90 Å R-free 0.250 |
| 2AF2 Solution structure of disulfide reduced and copper depleted Human Superoxide Dismutase Deposited 2005-07-25 | Different mutation/modification Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A, C111S Mutation：C6A, C111S | ZN ZINC ION × 2 |
SOLUTION NMR
NMR measurement conditions
pH 5；298 K；Ionic strength (raw mmCIF value) 20mM sodium phosphate；Pressure 1
NMR sample composition
1.5mM 15N protein sample | 20mM sodium phosphate, 20mM DTT buffer, pH 5, 90% H2O, 10% D2O
NMR sample composition
1mM 15N;13C protein sample | 20mM sodium phosphate, 20mM DTT buffer, pH 5, 90% H2O, 10% D2O
NMR sample composition
1mM 15N;13C;2H protein sample. The triple labeled dimeric SOD contained about 70% 2H | 20mM sodium phosphate, 20mM DTT, buffer, pH 5, 90% H2O, 10% D2O
|
Resolution not provided |
| 2C9S 1.24 Angstroms resolution structure of Zn-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 6 ACT ACETATE ION × 3 SO4 SULFATE ION × 6 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；2.5M AMMONIUM SULPHATE,0.1M NACL,50MM ACETATE BUFFER, pH 4.75
|
Resolution 1.24 Å R-free 0.194 |
| 2C9U 1.24 Angstroms resolution structure of as-isolated Cu-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | SO4 SULFATE ION × 3 CU COPPER (II) ION × 2 ZN ZINC ION × 4 ACT ACETATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 8；3.0 M AMMONIUM SULPHATE, 100 MM SODIUM CHLORITE, 50MM SODIUM ACETATE BUFFER, pH 8.00
|
Resolution 1.24 Å R-free 0.176 |
| 2C9V Atomic resolution structure of Cu-Zn Human Superoxide dismutase Deposited 2005-12-14 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 NA SODIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；3.0M AMMONIUM SULPHATE, 0.1M NACL, 50MM ACETATE BUFFER, pH 4.75
|
Resolution 1.07 Å R-free 0.158 |
| 2GBT C6A/C111A CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A/C111A Mutation：C6A/C111A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；18% PEG8000, 50mM TRIS-HCL, 50mM NaAc, 1mM EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.230 |
| 2GBT C6A/C111A CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：C6A/C111A Mutation：C6A/C111A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；18% PEG8000, 50mM TRIS-HCL, 50mM NaAc, 1mM EDTA, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 1.70 Å R-free 0.230 |
| 2GBU C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；25% PEG4000, 0.1M Na Cacodylate, 50mM NaAc, 1mM EDTA, 1mM NaN3, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.257 |
| 2GBU C6A/C111A/C57A/C146A apo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；291 K；25% PEG4000, 0.1M Na Cacodylate, 50mM NaAc, 1mM EDTA, 1mM NaN3, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.257 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–153（153 aa）
Chain G
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain H
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–153（153 aa）
Chain I
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2GBV C6A/C111A/C57A/C146A holo CuZn Superoxide dismutase Deposited 2006-03-11 | Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–153（153 aa）
Chain J
1–153（153 aa）
|
Mutation：C6A/C111A/C57A/C146A Mutation：C6A/C111A/C57A/C146A | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；291 K；2.8M Ammonium Sulphate, 50mM NaAc, 0.1M TRIS-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
|
Resolution 2.00 Å R-free 0.207 |
| 2LU5 Structure and chemical shifts of Cu(I),Zn(II) superoxide dismutase by solid-state NMR Deposited 2012-06-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111S | CU COPPER (II) ION × 1 |
SOLID-STATE NMR
NMR measurement conditions
pH 5；286 K；Ionic strength (raw mmCIF value) 0.02；Pressure ambient
NMR sample composition
3.5 mg [U-13C; U-15N; U-2H] Superoxide dismutase C6A/C111S thermostable mutant, 20 mM Sodium Citrate, 20% w/v Polyethylene Glycol 6000, 100% H2O | 100% H2O
|
Resolution not provided |
| 2MP3 Truncated L126Z-sod1 in DPC micelle Deposited 2014-05-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–126（125 aa）
Fragment：UNP residues 2-126
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4；313 K；Pressure ambient
NMR sample composition
20 mM dodecylphosphocholine (DPC)-1, 400 uM [U-100% 13C; U-100% 15N] protein-2, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NAM Full-length WT SOD1 in DPC MICELLE Deposited 2016-01-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
SOLUTION NMR
NMR measurement conditions
pH 4；313 K；Ionic strength (raw mmCIF value) 0；Pressure ambient
NMR sample composition
20 mM DPC-1, 0.4 mM [U-13C; U-15N] entity-2, 90% H2O/10% D2O | 90% H2O/10% D2O
|
Resolution not provided |
| 2NNX Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase Deposited 2006-10-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain B
1–153（153 aa）
|
Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；25% PEG 550MME, 0.1M MES, 0.01M zinc sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.241 |
| 2NNX Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase Deposited 2006-10-24 | Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–153（153 aa）
Chain D
1–153（153 aa）
|
Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：H46R, H48Q Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.8；298 K；25% PEG 550MME, 0.1M MES, 0.01M zinc sulfate, pH 5.8, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.30 Å R-free 0.241 |
| 2R27 Constitutively zinc-deficient mutant of human superoxide dismutase (SOD), C6A, H80S, H83S, C111S Deposited 2007-08-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：C7A, H81S, D84S, C112S Mutation：C7A, H81S, D84S, C112S | CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；295 K；2.45 M ammonium sulfate, 200 mM NaCl in 50 mM Tris, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.00 Å R-free 0.246 |
| 2V0A Atomic resolution crystal structure of Human Superoxide Dismutase Deposited 2007-05-11 | Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–153（153 aa）
Chain F
1–153（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；3.5 M AMMONIUM SULPHATE, 100MM NACL, 50MM ACETATE BUFFER PH 4.75
|
Resolution 1.15 Å R-free 0.206 |
| 2VR6 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.3 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% P3350 0.2 M NA THYOCYANATE, pH 7.0
|
Resolution 1.30 Å R-free 0.182 |
| 2VR7 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.58 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 6 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% PEG3350, 0.2M SODIUM THIOCYANATE, pH 7.0
|
Resolution 1.58 Å R-free 0.175 |
| 2VR8 Crystal Structure of G85R ALS mutant of Human Cu,Zn Superoxide Dismutase (CuZnSOD) at 1.36 A resolution Deposited 2008-03-28 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 6 SO4 SULFATE ION × 2 SCN THIOCYANATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7；20% PEG3350, 0.2M SODIUM THIOCYANATE, pH 7.0
|
Resolution 1.36 Å R-free 0.153 |
| 2WKO Structure of metal loaded Pathogenic SOD1 Mutant G93A. Deposited 2009-06-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：RESIDUES 2-154
Chain F
2–154（153 aa）
Fragment：RESIDUES 2-154
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 IOD IODIDE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6.5；20% P3350, 0.2 M AMMONIUM IODIDE, pH 6.5
|
Resolution 1.97 Å R-free 0.231 |
| 2WYT 1.0 A resolution structure of L38V SOD1 mutant Deposited 2009-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 6 ACT ACETATE ION × 1 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2-3M AMMONIUM SULPHATE, 100 MM NA ACETATE BUFFER PH 4.75
|
Resolution 1.00 Å R-free 0.147 |
| 2WYZ L38V SOD1 mutant complexed with UMP Deposited 2009-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 4 CU COPPER (II) ION × 2 SO4 SULFATE ION × 4 U5P URIDINE-5'-MONOPHOSPHATE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；150 MM NACL, 3.0 M AMMONIUM SULPHATE, 100 MM TRIS PH 7.5
|
Resolution 1.70 Å R-free 0.239 |
| 2WZ0 L38V SOD1 mutant complexed with aniline. Deposited 2009-11-20 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 3 SO4 SULFATE ION × 2 ZZT 2-METHOXY-5-METHYLANILINE × 2 DMS DIMETHYL SULFOXIDE × 1 DSN D-SERINE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；150 MM NACL,3.0 M AMMONIUM SULPHATE, 100 MM TRIS-HCL PH 7.5
|
Resolution 1.72 Å R-free 0.260 |
| 2WZ5 L38V SOD1 mutant complexed with L-methionine. Deposited 2009-11-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 3 CU COPPER (II) ION × 2 SO4 SULFATE ION × 3 MET METHIONINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2.0-3.0 M AMMONIUM SULPHATE, 100 MM ACETATE BUFFER PH 4.75
|
Resolution 1.50 Å R-free 0.255 |
| 2WZ6 G93A SOD1 mutant complexed with Quinazoline. Deposited 2009-11-23 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ZN ZINC ION × 4 CU COPPER (II) ION × 2 ZO0 4-(4-METHYL-1,4-DIAZEPAN-1-YL)-2-(TRIFLUOROMETHYL)QUINAZOLINE × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 4.75；150 MM NACL, 2.0-3.0 M AMMONIUM SULPHATE, 100 MM ACETATE BUFFER PH 4.75
|
Resolution 1.55 Å R-free 0.248 |
| 2XJK Monomeric Human Cu,Zn Superoxide dismutase Deposited 2010-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | CU COPPER (II) ION × 1 ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 6；25% PEG 6000, 0.1M MES (PH 6.0), 0.01M ZNCL2
|
Resolution 1.45 Å R-free 0.199 |
| 2XJL Monomeric Human Cu,Zn Superoxide dismutase without Cu ligands Deposited 2010-07-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | ZN ZINC ION × 4 PEG DI(HYDROXYETHYL)ETHER × 1 NA SODIUM ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；25% PEG 6000, 0.1M SODIUM ACETATE (PH 5.0), 0.01M ZNCL2
|
Resolution 1.55 Å R-free 0.183 |
| 2ZKW Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group P21 Deposited 2008-03-31 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.2；293 K；0.2M Ammonium iodide, 20%(w/v) PEG3350, pH 6.2, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 1.90 Å R-free 0.252 |
| 2ZKX Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121 Deposited 2008-03-31 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；0.1M Sodium Acetate(pH 4.6), 1.5M Ammonium Sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.72 Å R-free 0.246 |
| 2ZKX Crystal structure of human Cu-Zn superoxide dismutase mutant G85R in space group I212121 Deposited 2008-03-31 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Mutation：G85R Mutation：G85R | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；293 K；0.1M Sodium Acetate(pH 4.6), 1.5M Ammonium Sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.72 Å R-free 0.246 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 2ZKY Crystal structure of human Cu-Zn superoxide dismutase mutant G93A Deposited 2008-03-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；0.1M Cacodylate(pH 6.5), 0.2M NaCl, 2.0M Ammonium sulfate, VAPOR DIFFUSION, SITTING DROP, temperature 293K
|
Resolution 2.40 Å R-free 0.235 |
| 3CQP Human SOD1 G85R Variant, Structure I Deposited 2008-04-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.95 Å R-free 0.223 |
| 3CQP Human SOD1 G85R Variant, Structure I Deposited 2008-04-03 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 MLI MALONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.95 Å R-free 0.223 |
| 3CQQ Human SOD1 G85R Variant, Structure II Deposited 2008-04-03 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 3 ACE ACETYL GROUP × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.90 Å R-free 0.240 |
| 3ECU Crystal structure of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.279 |
| 3ECU Crystal structure of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.279 |
| 3ECV Crystal structure of the ALS-related pathological mutant I113T of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350 , pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.277 |
| 3ECV Crystal structure of the ALS-related pathological mutant I113T of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 6.5；289.1 K；0.1 M MES
20% PEG 3350 , pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 1.90 Å R-free 0.277 |
| 3ECW Crystal structure of the ALS-related pathological mutant T54R of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；289.1 K；0.1 M HEPES
20% PEG 3350, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 2.15 Å R-free 0.297 |
| 3ECW Crystal structure of the ALS-related pathological mutant T54R of human apo Cu,Zn Superoxide Dismutase (SOD1) Deposited 2008-09-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；289.1 K；0.1 M HEPES
20% PEG 3350, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 289.1K
|
Resolution 2.15 Å R-free 0.297 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GQF Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q Deposited 2009-03-24 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | ZN ZINC ION × 2 CA CALCIUM ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；297 K；20% polyethylene glycol 1000, imidazole pH 8.0, calcium acetate, VAPOR DIFFUSION, HANGING DROP, temperature 297K
|
Resolution 2.20 Å R-free 0.242 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain B
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain D
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain F
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain H
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain J
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GTV Human-mouse SOD1 chimera Deposited 2009-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
Chain L
2–81（80 aa）
Fragment：residues 2-81 from human protein, residues 82-154 from mouse protein
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；298 K；0.1 m HEPES, 25% PEG 8000, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.20 Å R-free 0.231 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZO HUMAN SOD1 G93A Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：G93A Non-standard monomer：Yes (specific site not provided by mmCIF) | CU COPPER (II) ION × 2 ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；2.4 M sodium malonate, pH 6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.10 Å R-free 0.214 |
| 3GZP HUMAN SOD1 G93A Metal-free Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M ammonium sulfate, 0.1 M HEPES, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.248 |
| 3GZP HUMAN SOD1 G93A Metal-free Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M ammonium sulfate, 0.1 M HEPES, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 3.10 Å R-free 0.248 |
| 3GZQ HUMAN SOD1 A4V Metal-free Variant Deposited 2009-04-07 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：A4V Non-standard monomer：Yes (specific site not provided by mmCIF) | SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；1.6 M ammonium sulfate, 0.1 M MES, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.193 |
| 3H2P Human SOD1 D124V Variant Deposited 2009-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：D124V Mutation：D124V | ZN ZINC ION × 3 MLI MALONATE ION × 2 ACE ACETYL GROUP × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；2.4 M sodium malonate, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.55 Å R-free 0.202 |
| 3H2Q Human SOD1 H80R variant, P21 crystal form Deposited 2009-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H80R Mutation：H80R | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.3 M AMMONIUM SULFATE, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.222 |
| 3H2Q Human SOD1 H80R variant, P21 crystal form Deposited 2009-04-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：H80R Mutation：H80R | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；298 K；2.3 M AMMONIUM SULFATE, 0.1 M Tris, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.85 Å R-free 0.222 |
| 3HFF Monomeric human Cu,Zn Superoxide dismutase without Zn ligands Deposited 2009-05-11 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111A, F50E, G51E, H63S, H71S, H80S, D83S | ZN ZINC ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；16% PEG 6000, 10% Jeffamine M-600 (pH 7.0), 0.1M Tris-HCl (pH 8.0), 0.1M ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.281 |
| 3HFF Monomeric human Cu,Zn Superoxide dismutase without Zn ligands Deposited 2009-05-11 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：C6A, C111A, F50E, G51E, H63S, H71S, H80S, D83S | ZN ZINC ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；16% PEG 6000, 10% Jeffamine M-600 (pH 7.0), 0.1M Tris-HCl (pH 8.0), 0.1M ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 293K
|
Resolution 2.20 Å R-free 0.281 |
| 3K91 Polysulfane Bridge in Cu-Zn Superoxide Dismutase Deposited 2009-10-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：H46R, H48Q Mutation：H46R, H48Q | PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 4.6；298 K；0.17 M ammonium sulfate, 0.085 M sodium acetate, 25.5% PEG 4000, 15% glycerol, pH 4.6, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 1.75 Å R-free 0.218 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH3 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P212121 crystal form containing 12 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.277 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3KH4 Crystal structure of human Cu/Zn superoxide dismutase recombinantly produced in Leishmania tarantolae; P6522 crystal form containing 6 chains in the asymmetric unit Deposited 2009-10-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；292 K；21-25% (w/v) PEG4000, 0.1 M NaOAc, pH 4.2-5.2, vapor diffusion, hanging drop, temperature 292K
|
Resolution 3.50 Å R-free 0.208 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain B
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain D
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3LTV Mouse-human sod1 chimera Deposited 2010-02-16 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Insufficient information Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
Chain F
82–154（73 aa）
Fragment：;RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN,RESIDUES 2-81 FROM MOUSE PROTEIN, RESIDUES 82-154 FROM HUMAN PROTEIN
;
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.6；298 K；0.1 M SODIUM ACETATE, 25% PEG 4000, pH 4.6, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.45 Å R-free 0.265 |
| 3QQD Human SOD1 H80R variant, P212121 crystal form Deposited 2011-02-15 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；2.3 M AMMONIUM SULFATE, 0.1 M TRIS, TEMPERATURE 298K, pH 8.0, VAPOR DIFFUSION, HANGING DROP
|
Resolution 1.65 Å R-free 0.183 |
| 3RE0 Crystal structure of human apo Cu,Zn superoxide dismutase (SOD1) complexed with cisplatin Deposited 2011-04-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CPT Cisplatin × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；20% PEG 3350, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.28 Å R-free 0.290 |
| 3RE0 Crystal structure of human apo Cu,Zn superoxide dismutase (SOD1) complexed with cisplatin Deposited 2011-04-02 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | CPT Cisplatin × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7.5；298 K；20% PEG 3350, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 298K
|
Resolution 2.28 Å R-free 0.290 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain E
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain G
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
2–154（153 aa）
Chain I
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain K
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 3T5W 2ME modified human SOD1 Deposited 2011-07-28 | Different construct Different mutation/modification Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain L
2–154（153 aa）
Chain M
2–154（153 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | CU1 COPPER (I) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；289 K；15% PEG 3350, 300mM (NH4)2SO4, pH6.0, VAPOR DIFFUSION, HANGING DROP, temperature 289K
|
Resolution 1.80 Å R-free 0.241 |
| 4A7G Structure of human I113T SOD1 mutant complexed with 4-methylpiperazin- 1-yl)quinazoline in the p21 space group. Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | SO4 SULFATE ION × 5 12I 4-(4-METHYLPIPERAZIN-1-YL)QUINAZOLINE × 3 CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 M AMMONIUM SULPHATE
|
Resolution 1.24 Å R-free 0.175 |
| 4A7Q Structure of human I113T SOD1 mutant complexed with 4-(4-methyl-1,4- diazepan-1-yl)quinazoline in the p21 space group. Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | 4MQ 4-(4-METHYL-1,4-DIAZEPAN-1-YL)QUINAZOLINE × 2 SO4 SULFATE ION × 6 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE
|
Resolution 1.22 Å R-free 0.159 |
| 4A7S Structure of human I113T SOD1 mutant complexed with 5-Fluorouridine in the p21 space group Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 ACT ACETATE ION × 2 5UD 5-FLUOROURIDINE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE PH 5
|
Resolution 1.06 Å R-free 0.200 |
| 4A7T Structure of human I113T SOD1 mutant complexed with isoproteranol in the p21 space group Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | 5FW ISOPRENALINE × 5 SO4 SULFATE ION × 4 ACT ACETATE ION × 2 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE PH 5, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE
|
Resolution 1.45 Å R-free 0.188 |
| 4A7U Structure of human I113T SOD1 complexed with adrenaline in the p21 space group. Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | ALE L-EPINEPHRINE × 2 SO4 SULFATE ION × 4 CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 AMMONIUM SULPHATE PH 5
|
Resolution 0.98 Å R-free 0.153 |
| 4A7V Structure of human I113T SOD1 mutant complexed with dopamine in the p21 space group Deposited 2011-11-14 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：YES Mutation：YES | LDP L-DOPAMINE × 1 SO4 SULFATE ION × 4 CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 5；100 MM SODIUM ACETATE, 150 MM SODIUM CHLORIDE, 2.5 M AMMONIUM SULPHATE PH 5
|
Resolution 1.00 Å R-free 0.181 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain I
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4B3E Structure of copper-zinc superoxide dismutase complexed with bicarbonate. Deposited 2012-07-23 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 CO3 CARBONATE ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
pH 7.5；1 M AMMONIUM SULPHATE, 50 MM TRIS PH 8.0 AND 50 MM NACL
|
Resolution 2.15 Å R-free 0.215 |
| 4BCY Monomeric Human Cu,Zn Superoxide dismutase, mutation H43F Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：YES | CU COPPER (II) ION × 2 ZN ZINC ION × 1 CD CADMIUM ION × 6 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；25% PEG 400, 0.1M NA ACETATE PH 4.6, 0.1 M CDCL2, 20 C
|
Resolution 1.27 Å R-free 0.203 |
| 4BCZ Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form. Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–49（48 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain A
83–124（42 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain A
141–154（14 aa）
Fragment：RESIDUES 2049,83-124,141-154
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；30% PEG 1500, 0.1M MIB BUFFER, PH 4.0, 20 C
|
Resolution 1.93 Å R-free 0.220 |
| 4BCZ Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form. Deposited 2012-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–49（48 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain B
83–124（42 aa）
Fragment：RESIDUES 2049,83-124,141-154
Chain B
141–154（14 aa）
Fragment：RESIDUES 2049,83-124,141-154
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
293 K；30% PEG 1500, 0.1M MIB BUFFER, PH 4.0, 20 C
|
Resolution 1.93 Å R-free 0.220 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–49（48 aa）
Chain A
83–124（42 aa）
Chain A
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–49（48 aa）
Chain B
83–124（42 aa）
Chain B
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
2–49（48 aa）
Chain C
83–124（42 aa）
Chain C
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain D
2–49（48 aa）
Chain D
83–124（42 aa）
Chain D
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
2–49（48 aa）
Chain E
83–124（42 aa）
Chain E
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain F
2–49（48 aa）
Chain F
83–124（42 aa）
Chain F
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
2–49（48 aa）
Chain G
83–124（42 aa）
Chain G
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain H
2–49（48 aa）
Chain H
83–124（42 aa）
Chain H
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4BD4 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant H43F Deposited 2012-10-04 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
2–49（48 aa）
Chain I
83–124（42 aa）
Chain I
141–154（14 aa）
|
Mutation：YES Mutation：YES Mutation：YES | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
18 % PEG 1500, 15% GLYCEROL
|
Resolution 2.78 Å R-free 0.246 |
| 4FF9 Crystal Structure of cysteinylated WT SOD1. Deposited 2012-05-31 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CYS CYSTEINE × 1 ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.25；298 K；0.1M MES, pH 6.25, 20% PEG3350, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.50 Å R-free 0.335 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：UNP residues 2-154
Chain B
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Fragment：UNP residues 2-154
Chain D
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Fragment：UNP residues 2-154
Chain F
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Fragment：UNP residues 2-154
Chain H
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Fragment：UNP residues 2-154
Chain J
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCM Human SOD1 C57S Mutant, As-isolated Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
Fragment：UNP residues 2-154
Chain L
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | ZN ZINC ION × 4 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；0.2 M ammonium sulfate, 0.1 M bis-tris, 25% PEG 3350, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.20 Å R-free 0.262 |
| 4MCN Human SOD1 C57S Mutant, Metal-free Deposited 2013-08-21 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Fragment：UNP residues 2-154
Chain B
2–154（153 aa）
Fragment：UNP residues 2-154
|
Mutation：C57S Mutation：C57S | SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；3.2 M ammonium sulfate, 0.1 M MES, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 295K
|
Resolution 2.60 Å R-free 0.245 |
| 4NIN DSVISLS segment 101-107 from Human Superoxide Dismutase Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
102–108（7 aa）
Fragment：UNP residues 102-108
|
Not recorded | ZN ZINC ION × 10 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；0.1 M MES pH 6.0, 20% PEG 6000, and 5 mM ZnCl2, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 1.40 Å R-free 0.228 |
| 4NIO GVTGIAQ segment 147-153 from Human Superoxide Dismutase with I149T mutation associated with a familial form of amyotrophic lateral sclerosis Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
148–154（7 aa）
Fragment：UNP Residues 148-154
|
Mutation：I149T | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；0.1 M sodium acetate pH 4.5, 0.7 M hexanediol, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.30 Å R-free 0.233 |
| 4NIP GVIGIAQ segment 147-153 from Human Superoxide Dismutase Deposited 2013-11-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
148–154（7 aa）
Fragment：UNP Residues 148-154
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；1 M sodium acetate pH 4.5, 1.75 M ammonium sulfate, vapor diffusion, hanging drop, temperature 298K
|
Resolution 1.90 Å R-free 0.248 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain D
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4OH2 Crystal Structure of Cu/Zn Superoxide Dismutase I149T Deposited 2014-01-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：C6A, C111S, L149T Mutation：C6A, C111S, L149T | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；298 K；100mM NaCl, 100mM Tris-HCl pH 7.6, 2.8M (NH4)2SO4, VAPOR DIFFUSION, HANGING DROP, temperature 298K
|
Resolution 2.38 Å R-free 0.216 |
| 4XCR Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A Deposited 2014-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Mutation：I45A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；293 K；0.1 M Bis Tris and 2.0 M ammonium sulfate
|
Resolution 3.60 Å R-free 0.239 |
| 4XCR Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A Deposited 2014-12-18 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–154（153 aa）
|
Mutation：I45A | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5.5；293 K；0.1 M Bis Tris and 2.0 M ammonium sulfate
|
Resolution 3.60 Å R-free 0.239 |
| 5DLI Corkscrew assembly of SOD1 residues 28-38 Deposited 2015-09-05 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Fragment：Residues 29-39
Chain B
29–39（11 aa）
Fragment：Residues 29-39
Chain C
29–39（11 aa）
Fragment：Residues 29-39
Chain D
29–39（11 aa）
Fragment：Residues 29-39
Chain E
29–39（11 aa）
Fragment：Residues 29-39
Chain F
29–39（11 aa）
Fragment：Residues 29-39
Chain G
29–39（11 aa）
Fragment：Residues 29-39
Chain H
29–39（11 aa）
Fragment：Residues 29-39
|
Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K | GOL GLYCEROL × 1 IOD IODIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；reservoir contained 13% PEG 6000, 0.2M Sodium Citrate
|
Resolution 2.10 Å R-free 0.262 |
| 5IIW Corkscrew assembly of SOD1 residues 28-38 without potassium iodide Deposited 2016-03-01 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain B
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain C
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain D
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain E
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain F
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain G
29–39（11 aa）
Fragment：UNP Residues 29-39
Chain H
29–39（11 aa）
Fragment：UNP Residues 29-39
|
Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K Mutation：P29K | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；reservoir contained 13% PEG 6000, 0.2M Sodium Citrate
|
Resolution 2.00 Å R-free 0.252 |
| 5J07 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2 Deposited 2016-03-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
14–49（36 aa）
Chain A
84–124（41 aa）
Chain A
141–154（14 aa）
Chain A
2–13（12 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 2.00 Å R-free 0.231 |
| 5J07 Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P1/2 Deposited 2016-03-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
14–49（36 aa）
Chain B
84–124（41 aa）
Chain B
141–154（14 aa）
Chain B
2–13（12 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 2.00 Å R-free 0.231 |
| 5J0C Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
29–49（21 aa）
Chain A
84–124（41 aa）
Chain A
2–26（25 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 1.60 Å R-free 0.186 |
| 5J0C Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P2/3 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
29–49（21 aa）
Chain B
84–124（41 aa）
Chain B
2–26（25 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；pH 5；293 K；0.1 M MIB buffer
pH 5.0
25 % w/v PEG 1500
|
Resolution 1.60 Å R-free 0.186 |
| 5J0F Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5 Deposited 2016-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
83–124（42 aa）
Chain A
2–49（48 aa）
|
Not recorded | GOL GLYCEROL × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.17 M ammonium sulfate, 25.5 % w/v PEG 4K, 15 % v/v Glycerol
|
Resolution 1.25 Å R-free 0.170 |
| 5J0F Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P4/5 Deposited 2016-03-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
83–124（42 aa）
Chain B
2–49（48 aa）
|
Not recorded | GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
EVAPORATION；293 K；0.17 M ammonium sulfate, 25.5 % w/v PEG 4K, 15 % v/v Glycerol
|
Resolution 1.25 Å R-free 0.170 |
| 5J0G Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P7/8 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–124（123 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M di-ammonium hydrogen citrate,
20 % w/v PEG 3350
|
Resolution 2.50 Å R-free 0.235 |
| 5J0G Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, circular permutant P7/8 Deposited 2016-03-28 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
2–124（123 aa）
|
Not recorded | No recorded non-water small molecule |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；0.2 M di-ammonium hydrogen citrate,
20 % w/v PEG 3350
|
Resolution 2.50 Å R-free 0.235 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
Chain V
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain R
2–154（153 aa）
Chain U
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 12 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain S
2–154（153 aa）
Chain T
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
Chain L
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain J
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
Chain I
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
Chain H
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
Chain N
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
Chain X
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5K02 Structure of human SOD1 with T2D mutation Deposited 2016-05-17 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
Chain W
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；298 K；T2D was crystallized in a buffer of 2 M (NH4)2SO4, 0.1 M Sodium Cacodylate, 20% MPD and 10 mM ZnCl2 (pH 6.5) after a period of approximately 5 months.
|
Resolution 1.99 Å R-free 0.162 |
| 5O3Y SOD1 bound to Ebsulfur Deposited 2017-05-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 9JK ~{N}-phenyl-2-sulfanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 3.75；293 K；100 mM NaAct pH 3.75, 100 mM NaCl, 2.8 M AmSO4
|
Resolution 1.30 Å R-free 0.186 |
| 5O40 SOD1 bound to Ebselen Deposited 2017-05-25 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 9JT N-phenyl-2-selanylbenzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4；293 K；100 mM NaACT pH 4, 2.4 M AMSO4, 150 mM NaCl
|
Resolution 1.50 Å R-free 0.215 |
| 5U9M Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site Deposited 2016-12-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：H46R,H48Q | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；25 % PEG 3350, 0.2 M ammonium sulfate, 0.1 M bis-tris pH 6.5
|
Resolution 2.35 Å R-free 0.235 |
| 5U9M Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site Deposited 2016-12-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：H46R,H48Q | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；298 K；25 % PEG 3350, 0.2 M ammonium sulfate, 0.1 M bis-tris pH 6.5
|
Resolution 2.35 Å R-free 0.235 |
| 5WMJ KVWGSI segment from Superoxide Dismutase 1,residues 30-35 Deposited 2017-07-28 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
31–36（6 aa）
Fragment：UNP residues 31-36
Chain B
31–36（6 aa）
Fragment：UNP residues 31-36
|
Not recorded | TFA trifluoroacetic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；Reservoir solution contained 4M Sodium Formate
|
Resolution 1.40 Å R-free 0.170 |
| 5WOR Corkscrew assembly of SOD1 residues 28-38 with familial mutation G37R Deposited 2017-08-02 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 20 PDB declaration: eicosameric |
Chain A
29–39（11 aa）
Fragment：UNP residues 29-39
Chain B
29–39（11 aa）
Fragment：UNP residues 29-39
Chain C
29–39（11 aa）
Fragment：UNP residues 29-39
Chain D
29–39（11 aa）
Fragment：UNP residues 29-39
Chain E
29–39（11 aa）
Fragment：UNP residues 29-39
Chain F
29–39（11 aa）
Fragment：UNP residues 29-39
Chain G
29–39（11 aa）
Fragment：UNP residues 29-39
Chain H
29–39（11 aa）
Fragment：UNP residues 29-39
Chain I
29–39（11 aa）
Fragment：UNP residues 29-39
Chain J
29–39（11 aa）
Fragment：UNP residues 29-39
|
Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R Mutation：P29K,G38R | MLI MALONATE ION × 6 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；reservoir contained 15% PEG 3350, 0.3M Sodium Malonate
|
Resolution 2.77 Å R-free 0.247 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 PS5 PENTASULFIDE-SULFUR × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 946 4-[(1~{R})-2-(naphthalen-2-ylmethylamino)-1-oxidanyl-ethyl]benzene-1,2-diol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTO Crystal Structure of human Superoxide Dismutase I (hSOD1) in complex with a napthalene-catechol linked compound. Deposited 2017-11-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；sodium citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.215 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | 5FW ISOPRENALINE × 1 ZN ZINC ION × 2 TAM TRIS(HYDROXYETHYL)AMINOMETHANE × 1 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YTU Structure of human SOD1 complexed with isoproteranol in C2221 space group Deposited 2017-11-20 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate, pH 6.0
|
Resolution 1.90 Å R-free 0.221 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 5YUL Native Structure of hSOD1 in P6322 space group Deposited 2017-11-22 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；300 K；Sodium Citrate pH 6.0
|
Resolution 1.90 Å R-free 0.227 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 GOL GLYCEROL × 2 S4P Dihydrogen tetrasulfide × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 S4P Dihydrogen tetrasulfide × 1 6B3 2'-[(6-oxo-5,6-dihydrophenanthridin-3-yl)carbamoyl][1,1'-biphenyl]-2-carboxylic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6A9O Rational discovery of a SOD1 tryptophan oxidation inhibitor with therapeutic potential for amyotrophic lateral sclerosis Deposited 2018-07-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；1.5M Sodium Citrate, pH 6.0
|
Resolution 2.50 Å R-free 0.237 |
| 6B79 Curved pair of sheets formed from SOD1 residues 28-38 with familial mutation G37R. Deposited 2017-10-03 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 8 PDB declaration: octameric |
Chain A
29–39（11 aa）
Chain B
29–39（11 aa）
|
Non-standard monomer：Yes (specific site not provided by mmCIF) Non-standard monomer：Yes (specific site not provided by mmCIF) | ORA 7-hydroxy-8-[(E)-phenyldiazenyl]naphthalene-1,3-disulfonic acid × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.5；298 K；HEPES pH 7.5, Sodium citrate, 2-Methyl-2,4-pentanediol
|
Resolution 1.80 Å R-free 0.267 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–154（154 aa）
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain C
1–154（154 aa）
Chain C
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain E
1–154（154 aa）
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 MLI MALONATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain G
1–154（154 aa）
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6DTK Heterodimers of FALS mutant SOD enzyme Deposited 2018-06-17 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain I
1–154（154 aa）
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；298 K；2-3 M Ammonium sulfate or Sodium malonate
|
Resolution 2.00 Å R-free 0.190 |
| 6FFK Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH Deposited 2018-01-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | D7Z PtCl2(1(R),2(R)-DACH) × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES, 20% PEG 3350
|
Resolution 1.94 Å R-free 0.256 |
| 6FFK Human apo-SOD1 bound to PtCl2(1R,2R-1,4-DACH Deposited 2018-01-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | D7Z PtCl2(1(R),2(R)-DACH) × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；pH 7；293 K；0.1 M HEPES, 20% PEG 3350
|
Resolution 1.94 Å R-free 0.256 |
| 6FLH Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form Deposited 2018-01-25 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
2–154（153 aa）
|
Not recorded | SO4 SULFATE ION × 1 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M sodium acetate pH 4.6 and 2 M ammonium sulfate
|
Resolution 1.79 Å R-free 0.197 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
2–154（153 aa）
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain K
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
Chain O
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
Chain S
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOI Human Cys57/156Ala superoxide dismutase-1 (SOD1), as isolated. Deposited 2018-02-07 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
Chain W
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 8；293 K；0.2 M Lithium sulphate
24% w/v PEG 4000
0.1 M Tris-HCl pH 8.0
|
Resolution 2.00 Å R-free 0.259 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain B
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PE8 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FOL Domain II of the human copper chaperone in complex with human Cu,Zn superoxide dismutase Deposited 2018-02-07 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；25% (w/v) PEG 1500 and 0.1 M PCTP buffer pH 7.0 (sodium propionate, sodium cacodylate, and BIS-TRIS propane in the molar ratios 2:1:2, respectively)
|
Resolution 2.55 Å R-free 0.248 |
| 6FON Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 Deposited 2018-02-07 | Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain B
2–154（153 aa）
Chain D
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.1 M MES pH 6.0
0.2 M Magnesium chloride
20 % (w/v) PEG 6000
|
Resolution 3.05 Å R-free 0.246 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 2 GOL GLYCEROL × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain S
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 12 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain W
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain M
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain O
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6FP6 Complex of human Cu,Zn SOD1 with the human copper chaperone for SOD1 in a compact conformation Deposited 2018-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain Q
2–154（153 aa）
|
Mutation：C57A; C146A | ZN ZINC ION × 2 PPI PROPANOIC ACID × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M PCTP buffer pH 9.0, 20% (w/v) PEG 3350.
|
Resolution 3.00 Å R-free 0.230 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain G
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPA A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 IN C2 SPACE GROUP Deposited 2019-08-31 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain L
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 1.65 Å R-free 0.196 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain G
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 3 SO4 SULFATE ION × 1 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPH A4V MUTANT OF HUMAN SUPEROXIDE DISMUTASE 1 WITH EBSELEN BOND IN C2 SPACE GROUP Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
2–154（153 aa）
Chain L
2–154（153 aa）
|
Mutation：Ala4Val Mutation：Ala4Val | ZN ZINC ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 1 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；100 mM Tris-HCl pH 7.4-8.0, 2.4-2.6 M ammonium sulphate, 150 mM NaCl
|
Resolution 2.25 Å R-free 0.222 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain J
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 4 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain B
1–154（154 aa）
Chain K
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain I
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain L
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain G
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPI A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 4 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain H
1–154（154 aa）
|
Mutation：A4V Mutation：A4V | LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；100mM Tris-HCl pH 7.8, 2.6 M ammonium sulphate
|
Resolution 2.80 Å R-free 0.241 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 13 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 3 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 7 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPJ A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 1 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LR2 ~{N}-pyridin-2-yl-2-selanyl-benzamide × 2 SO4 SULFATE ION × 10 GOL GLYCEROL × 2 DMS DIMETHYL SULFOXIDE × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 1.97 Å R-free 0.225 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 2 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 1 CL CHLORIDE ION × 3 DMS DIMETHYL SULFOXIDE × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 2 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 10 CL CHLORIDE ION × 3 DMS DIMETHYL SULFOXIDE × 2 NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6SPK A4V MUTANT OF HUMAN SOD1 WITH EBSELEN DERIVATIVE 6 Deposited 2019-09-01 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
Chain J
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 3 LQN 2-selanyl-~{N}-[3-[4-(trifluoromethyl)phenyl]phenyl]benzamide × 2 SO4 SULFATE ION × 8 CL CHLORIDE ION × 3 NA SODIUM ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 7.6；293 K；2.6 M Ammonium sulphate, 100 mM Tris-HCl pH 7.6, 150 mM NaCl
|
Resolution 2.77 Å R-free 0.229 |
| 6Z3V A4V mutant of human SOD1 bound with N-aryl benzoisoselenazolone derivative 13 in P21 space group Deposited 2020-05-22 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q6H 5-fluoranyl-~{N}-(3-morpholin-4-ylcarbonylphenyl)-2-selanyl-benzamide × 2 SO4 SULFATE ION × 5 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.25 Å R-free 0.191 |
| 6Z4G A4V mutant of human SOD1 bound with ebselen in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 ACT ACETATE ION × 2 9JT N-phenyl-2-selanylbenzamide × 2 SO4 SULFATE ION × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.45 Å R-free 0.193 |
| 6Z4H A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 2 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 LQW ~{N}-[(4-chlorophenyl)methyl]-2-selanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.6M ammonium sulphate
|
Resolution 1.95 Å R-free 0.242 |
| 6Z4I A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 3 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain FFF
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 ACT ACETATE ION × 2 SO4 SULFATE ION × 2 Q85 ~{N}-[(4-methoxyphenyl)methyl]-2-selanyl-benzamide × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.60 Å R-free 0.217 |
| 6Z4J A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 5 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q7W ~{N}-[(3-chlorophenyl)methyl]-2-selanyl-benzamide × 2 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.5M ammonium sulphate
|
Resolution 1.55 Å R-free 0.208 |
| 6Z4K A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 6 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q7N ~{N}-[(3-methoxyphenyl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 4 CL CHLORIDE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.45 Å R-free 0.209 |
| 6Z4L A4V mutant of human SOD1 bound with 2-(pyridin-3-ylmethyl)benzoisoselenazolone derivative 9 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q8H ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.60 Å R-free 0.208 |
| 6Z4M A4V mutant of human SOD1 bound with 2-(pyridin-3-ylmethyl)benzoisoselenazolone derivative 10 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | Q8E ~{N}-[(6-methoxypyridin-3-yl)methyl]-2-selanyl-benzamide × 2 ZN ZINC ION × 4 CL CHLORIDE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.55 Å R-free 0.208 |
| 6Z4O A4V mutant of human SOD1 bound with benzyl benzoisoselenazolone derivative 1 in P21 space group Deposited 2020-05-25 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain AAA
2–154（153 aa）
Chain BBB
2–154（153 aa）
|
Mutation：A4V Mutation：A4V | ZN ZINC ION × 4 Q7T ~{N}-(phenylmethyl)-2-selanyl-benzamide × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.232 |
| 7FB6 C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain A
1–154（154 aa）
|
Mutation：C57D/C146D Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 1 CU COPPER (II) ION × 1 CL CHLORIDE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.2M MgCl2, 22% (w/v) PEG 3350
|
Resolution 1.80 Å R-free 0.213 |
| 7FB6 C57D/C146D mutant of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain B
1–154（154 aa）
|
Mutation：C57D/C146D Non-standard monomer：Yes (specific site not provided by mmCIF) | ZN ZINC ION × 1 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.2M MgCl2, 22% (w/v) PEG 3350
|
Resolution 1.80 Å R-free 0.213 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain I
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain H
1–154（154 aa）
Chain L
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain J
1–154（154 aa）
Chain K
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 CU COPPER (II) ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain M
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7FB9 Crystal Structure of Human Cu, Zn Superoxide Dismutase (SOD1) Deposited 2021-07-08 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric |
Chain N
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；287.15 K；0.1M sodium acetate-HCl (pH 4.5), 21% (w/v) PEG 3350
|
Resolution 2.70 Å R-free 0.247 |
| 7NXX Structure of Superoxide Dismutase 1 (SOD1) in complex with nanobody 2 (Nb2). Deposited 2021-03-19 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；273 K；0.1 M Hepes,1.5 M Lithium sulphate, pH 7.5
|
Resolution 2.19 Å R-free 0.245 |
| 7T8E G93A mutant of human SOD1 in P21 space group Deposited 2021-12-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.229 |
| 7T8F G93A mutant of human SOD1 bound with Ebselen in P21 space group Deposited 2021-12-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 9JT N-phenyl-2-selanylbenzamide × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.40 Å R-free 0.225 |
| 7T8G G93A mutant of human SOD1 bound with MR6-8-2 in P21 space group Deposited 2021-12-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 Q8H ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide × 2 ACT ACETATE ION × 1 SO4 SULFATE ION × 2 SE SELENIUM ATOM × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.35 Å R-free 0.202 |
| 7T8H G93A mutant of human SOD1 bound with MR6-26-2 in P21 space group Deposited 2021-12-16 | Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain F
2–154（153 aa）
|
Mutation：G93A Mutation：G93A | ZN ZINC ION × 4 ACT ACETATE ION × 1 Q8E ~{N}-[(6-methoxypyridin-3-yl)methyl]-2-selanyl-benzamide × 2 SO4 SULFATE ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.7；292 K；100mM NaOAc pH 4.7, 150mM NaCl, 2.7M ammonium sulphate
|
Resolution 1.50 Å R-free 0.224 |
| 7VZF Cryo-EM structure of amyloid fibril formed by full-length human SOD1 Deposited 2021-11-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.95 Å |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 4 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
Chain G
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 7XX3 Crystal structure of human Superoxide Dismutase (SOD1) in complex with a fungal metabolite molecule, Phialomustin B (PB) Deposited 2022-05-28 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 I2G (2~{E},4~{E},6~{S})-4,6-dimethyldeca-2,4-dienoic acid × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate (pH = 6.5)
|
Resolution 1.90 Å R-free 0.230 |
| 8CCX Human SOD1 in complex with S-XL6 cross-linker Deposited 2023-01-27 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 4 SO4 SULFATE ION × 2 UDI butane-1,4-dithiol × 1 DMS DIMETHYL SULFOXIDE × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 4.75；293 K；2.5M ammonium sulphate, 150mM NaCl, sodium acetate pH 4.75
|
Resolution 1.67 Å R-free 0.233 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8GSQ Structure based studies reveal an atypical antipsychotic drug candidate - Paliperidone as a potent hSOD1 modulator with implications in ALS treatment. Deposited 2022-09-06 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；Sodium Citrate
|
Resolution 2.10 Å R-free 0.208 |
| 8IHU Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation G85R Deposited 2023-02-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.97 Å |
| 8IHV Cryo-EM structure of an amyloid fibril formed by ALS-causing SOD1 mutation H46R Deposited 2023-02-23 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.11 Å |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 10 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain Y
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 11 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain U
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 12 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain W
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain K
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 7 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain L
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 8 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain N
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K33 SOD1 and Nanobody1 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 9 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain P
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 8.5；291 K；0.2 M Ammonium acetate, 0.1 M Tris pH 8.5, 25% w/v Polyethylene glycol 3,350
|
Resolution 2.13 Å R-free 0.265 |
| 8K3A SOD1 and Nanobody2 complex Deposited 2023-07-14 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Magnesium chloride, 0.1 M Sodium, citrate pH 5, 15%(w/v) PEG 4000
|
Resolution 2.74 Å R-free 0.256 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain C
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain E
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8K3L SOD1 and Nanobody3 complex Deposited 2023-07-16 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric |
Chain G
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 1 ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2 M Ammonium acetate, 0.1 M Sodium acetate trihydrate pH 4.6, 30% w/v
Polyethylene, glycol monomethyl ether 2,000
|
Resolution 2.30 Å R-free 0.235 |
| 8Q6M Human SOD1 low dose data collecton Deposited 2023-08-14 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ACT ACETATE ION × 1 ZN ZINC ION × 2 CU COPPER (II) ION × 2 SO4 SULFATE ION × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；pH 4.75；293 K；2.5 M Ammonium sulphate, Acetate buffer pH 4.75
|
Resolution 1.77 Å R-free 0.251 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain D
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain H
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain L
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain P
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAF SOD1, Nanobody1 and Nanobody2 complex Deposited 2024-02-09 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein heterocomplex Heteromer；Protein × 3 PDB declaration: trimeric |
Chain T
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；5% (v/v) Isopropanol, 2.0 M Ammonium sulfate
|
Resolution 3.28 Å R-free 0.249 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain A
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain E
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain I
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YAT SOD1, Nanobody1, Nanobody2 and Nanobody3 complex Deposited 2024-02-10 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein heterocomplex Heteromer；Protein × 4 PDB declaration: tetrameric |
Chain M
2–154（153 aa）
|
Not recorded | ZN ZINC ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION；293 K；0.2M Ammonium sulfate, 0.1M HEPES pH8.0, 20%w/v Polyethylene glycol 3350
|
Resolution 3.94 Å R-free 0.368 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 A1LYN (2S)-decane-1,2,10-triol × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 2 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 GOL GLYCEROL × 1 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 1 A1LYN (2S)-decane-1,2,10-triol × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 8YD3 Crystal structure of human Cu-Zn Superoxide Dismutase 1 in complex with 1,2,10-Decanetriol Deposited 2024-02-19 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | ZN ZINC ION × 2 A1LYN (2S)-decane-1,2,10-triol × 3 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；1.3 M Sodium citrate
|
Resolution 1.96 Å R-free 0.211 |
| 9IYD Cryo-EM structure of an amyloid fibril formed by SOD1 mutant - G93A Deposited 2024-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Mutation：G94A Mutation：G94A Mutation：G94A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.09 Å |
| 9IYJ Cryo-EM structure of an amyloid fibril formed by SOD1 mutant - D101N Deposited 2024-07-30 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
Chain C
2–154（153 aa）
|
Mutation：D102N Mutation：D102N Mutation：D102N | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7.4
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 2.92 Å |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 3 ACT ACETATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 ACT ACETATE ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain K
1–154（154 aa）
Chain L
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain G
1–154（154 aa）
Chain H
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9IYK Crystal structure of hSOD1 in C121 space group Deposited 2024-07-30 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain I
1–154（154 aa）
Chain J
1–154（154 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 SO4 SULFATE ION × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate
|
Resolution 2.34 Å R-free 0.263 |
| 9JBO Cryo-EM structure of human SOD1 (WT) amyloid filament Deposited 2024-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.39 Å |
| 9JBP Cryo-EM structure of human SOD1 (C6A/C111A) amyloid filament Deposited 2024-08-27 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein heterocomplex Heteromer；Protein × 12 PDB declaration: dodecameric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
Chain D
1–154（154 aa）
Chain E
1–154（154 aa）
Chain F
1–154（154 aa）
|
Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A Mutation：C6A,C111A | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 3.18 Å |
| 9LI1 Cryo-EM structure of human SOD1 (G93A) amyloid filament Deposited 2025-01-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric |
Chain A
1–154（154 aa）
Chain B
1–154（154 aa）
Chain C
1–154（154 aa）
|
Not recorded | No recorded non-water small molecule |
ELECTRON MICROSCOPY
cryo-EM buffer
pH 7
cryo-EM vitrification conditions
Cryogen ETHANE
|
Resolution 4.74 Å |
| 9MIL Superoxide dismutase residues 28-39 with G37R mutation Deposited 2024-12-13 | Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 10 PDB declaration: decameric |
Chain A
29–40（12 aa）
Chain B
29–40（12 aa）
Chain C
29–40（12 aa）
Chain D
29–40（12 aa）
Chain E
29–40（12 aa）
Chain F
29–40（12 aa）
Chain G
29–40（12 aa）
Chain H
29–40（12 aa）
Chain I
29–40（12 aa）
Chain J
29–40（12 aa）
|
Not recorded | SO4 SULFATE ION × 5 PG4 TETRAETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 1 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；1.0 M Ammonium sulfate, 0.1 M BIS-TRIS pH 5.5, 1% w/v Polyethylene glycol 3,350
|
Resolution 2.50 Å R-free 0.263 |
| 9XJ0 Crystal structure of SOD1 by serial synchrotron crystallography Deposited 2025-11-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate, PVP-K15
|
Resolution 2.30 Å R-free 0.210 |
| 9XJI Cryogenic structure of SOD1, determined as the SSX counterpart Deposited 2025-11-04 | Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics | Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric |
Chain A
2–154（153 aa）
Chain B
2–154（153 aa）
|
Not recorded | CU COPPER (II) ION × 2 ZN ZINC ION × 2 |
X-RAY DIFFRACTION
X-ray crystallization conditions
VAPOR DIFFUSION, SITTING DROP；293 K；Ammonium sulfate, sodium acetate, PVP-K15
|
Resolution 2.37 Å R-free 0.231 |
153 other PDB entries and 371 assemblies. Open the comparison page and filter oligomeric states
View Construct and Data Evidence
| UniProt name | SODC_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 1–153； UniProt 1–153 Author chain B； PDBConstruct 1–153； UniProt 1–153 Author chain C； PDBConstruct 1–153； UniProt 1–153 Author chain D； PDBConstruct 1–153； UniProt 1–153 Author chain E； PDBConstruct 1–153； UniProt 1–153 Author chain F； PDBConstruct 1–153； UniProt 1–153 Author chain G； PDBConstruct 1–153； UniProt 1–153 Author chain H； PDBConstruct 1–153； UniProt 1–153 Author chain I； PDBConstruct 1–153； UniProt 1–153 Author chain J； PDBConstruct 1–153； UniProt 1–153 |
