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1tmt

CHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

ALPHA-THROMBIN (SMALL SUBUNIT)

Homo sapiens

UniProt P00734

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 CGP 50,856 INHIBITOR, cleaved N-terminal tripeptide fragment, d-Phe-Pro-Arg × 1 CGP 50,856 INHIBITOR, cleaved C-terminal hirudin fragment × 1 （P28504） 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1cgl 1cgl 1jwt 1mh0 1mh0 3nxp 3sqe 3sqh 4h6t 4hzh 4hzh 4nzq

19 assemblies; showing the first 12

Homodimer
1abj 1awh 1awh 1hai 1jou 1jou 1jou 1ppb 1sfq 1sfq 1sg8 1sg8

74 assemblies; showing the first 12

Homotetramer
1sg8 1tq0 2a0q 2afq 2hnt 3jz1 3r3g 6p9u 6p9u 6p9u 6p9u

11 assemblies

Other homooligomers
2hpq

1 assemblies

Heteromeric or nucleic-acid complex
1a2c 1a3b 1a3e 1a46 1a4w 1a5g 1a61 1abi 1ad8 1ae8 1afe 1aht

460 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name THRB_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain L； PDBConstruct 1–36； UniProt 328–363 Author chain H； PDBConstruct 1–259； UniProt 364–622

CGP 50,856 INHIBITOR, cleaved C-terminal hirudin fragment

OrganismNot specified

UniProt P28504

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 ALPHA-THROMBIN (SMALL SUBUNIT) × 1 （P00734） ALPHA-THROMBIN (LARGE SUBUNIT) × 1 （P00734） CGP 50,856 INHIBITOR, cleaved N-terminal tripeptide fragment, d-Phe-Pro-Arg × 1 2-acetamido-2-deoxy-beta-D-glucopyranose × 1 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1a3b 1a3e 1abi 1c1u 1c1v 1c1w 1c4u 1c5l 1c5n 1c5o 1d9i 1fpc

56 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name HIR2_HIRME
Isoform —
PDB entities 4
Chains and sequence ranges Author chain J； PDBConstruct 6–18； UniProt 53–65

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1tmt
Deposition date deposition_date1994-05-26
Structure title titleCHANGES IN INTERACTIONS IN COMPLEXES OF HIRUDIN DERIVATIVES AND HUMAN ALPHA-THROMBIN DUE TO DIFFERENT CRYSTAL FORMS
Keywords keywordsCOMPLEX, SERINE PROTEASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX; HYDROLASE/HYDROLASE INHIBITOR
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1tmt__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1tmt__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1tmt__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.39 Å
Rg (electron density)18.16 Å
Total Rg19.15 Å
Atom count2415
Residues298
Excluded volume42925 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1tmt__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 3 domains

SCOP 2.08 (1 domains)

Domain ID domain_idd1tmt.1
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases

CATH v4.4 (2 domains)

Domain ID domain_id1tmtH01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tmtH02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
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7. Citations (5)