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1tx6

trypsin:BBI complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Trypsin

OrganismNot specified

UniProt P00761

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Bowman-Birk type trypsin inhibitor × 1 （P12940） CALCIUM ION × 2 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Bowman-Birk type trypsin inhibitor × 1 （P12940） CALCIUM ION × 2 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1fmg 1fn6 1fni 1qqu 1s5s 1s6f 1s6h 1s81 1s82 1s83 1s84 1s85

21 assemblies; showing the first 12

Homodimer
1aks

1 assemblies

Homotetramer

None

Other homooligomers
1ept 1uhb

2 assemblies

Heteromeric or nucleic-acid complex
1an1 1avw 1avx 1c9p 1eja 1h9h 1h9i 1ldt 1mct 1tfx 1tfx 1tx6

31 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name TRYP_PIG
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–223； UniProt 9–231 Author chain B； PDBConstruct 1–223； UniProt 9–231 Author chain C； PDBConstruct 1–223； UniProt 9–231 Author chain D； PDBConstruct 1–223； UniProt 9–231

Bowman-Birk type trypsin inhibitor

OrganismNot specified

UniProt P12940

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 3 Trypsin × 2 （P00761） CALCIUM ION × 2 water × 3 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 3 Trypsin × 2 （P00761） CALCIUM ION × 2 water × 3 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1c2a 2fj8

2 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1tx6 1tx6

2 assemblies

View Construct and Data Evidence
UniProt name IBB_HORVU
Isoform —
PDB entities 2
Chains and sequence ranges Author chain I； PDBConstruct 1–125； UniProt 1–125 Author chain J； PDBConstruct 1–125； UniProt 1–125

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1tx6
Deposition date deposition_date2004-07-02
Structure title titletrypsin:BBI complex
Keywords keywords;anticarcinogenic activity, double-headed inhibitor, gene duplication, monocotyledonous plant, inhibitory loop, HYDROLASE-PROTEIN BINDING COMPLEX ;; HYDROLASE/PROTEIN BINDING
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1tx6__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1tx6__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1tx6__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.85 Å
Rg (electron density)27.90 Å
Total Rg28.36 Å
Atom count4120
Residues556
Excluded volume72882 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1tx6__assembly_1__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1tx6__assembly_2__model_1 trimeric （3） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 20 domains

SCOP 2.08 (8 domains)

Domain ID domain_idd1tx6a_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1tx6b_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1tx6c_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1tx6d_
Class classb — All beta proteins
Fold Fold foldb.47 — Trypsin-like serine proteases
Superfamily Superfamily superfamilyb.47.1 — Trypsin-like serine proteases
Family Family familyb.47.1.2 — Eukaryotic proteases
Domain ID domain_idd1tx6i1
Class classg — Small proteins
Fold Fold foldg.3 — Knottins (small inhibitors, toxins, lectins)
Superfamily Superfamily superfamilyg.3.13 — Bowman-Birk inhibitor, BBI
Family Family familyg.3.13.1 — Bowman-Birk inhibitor, BBI
Domain ID domain_idd1tx6i2
Class classg — Small proteins
Fold Fold foldg.3 — Knottins (small inhibitors, toxins, lectins)
Superfamily Superfamily superfamilyg.3.13 — Bowman-Birk inhibitor, BBI
Family Family familyg.3.13.1 — Bowman-Birk inhibitor, BBI
Domain ID domain_idd1tx6j1
Class classg — Small proteins
Fold Fold foldg.3 — Knottins (small inhibitors, toxins, lectins)
Superfamily Superfamily superfamilyg.3.13 — Bowman-Birk inhibitor, BBI
Family Family familyg.3.13.1 — Bowman-Birk inhibitor, BBI
Domain ID domain_idd1tx6j2
Class classg — Small proteins
Fold Fold foldg.3 — Knottins (small inhibitors, toxins, lectins)
Superfamily Superfamily superfamilyg.3.13 — Bowman-Birk inhibitor, BBI
Family Family familyg.3.13.1 — Bowman-Birk inhibitor, BBI

CATH v4.4 (12 domains)

Domain ID domain_id1tx6A01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6A02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6B01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6B02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6C01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6C02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6D01
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6D02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology10 — Thrombin, subunit H
Homologous superfamily homologous superfamily10 — Trypsin-like serine proteases
Domain ID domain_id1tx6I01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology69 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Homologous superfamily homologous superfamily10 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Domain ID domain_id1tx6I02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology69 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Homologous superfamily homologous superfamily10 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Domain ID domain_id1tx6J01
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology69 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Homologous superfamily homologous superfamily10 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Domain ID domain_id1tx6J02
Class class2 — Mainly Beta
Architecture architecture10 — Ribbon
Topology topology69 — Cysteine Protease (Bromelain) Inhibitor, subunit H
Homologous superfamily homologous superfamily10 — Cysteine Protease (Bromelain) Inhibitor, subunit H
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7. Citations (3)