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1tyl

THE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

INSULIN

Homo sapiens

UniProt P01308

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein homooligomer Homooligomer Protein 2 ZINC ION × 1 water × 2 Consistent with protein count
2 Protein homooligomer Homooligomer Protein 2 ZINC ION × 1 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 1 CHLORIDE ION × 1 water × 2 Consistent with protein count
3 Protein homooligomer Homooligomer Protein 12 ZINC ION × 6 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 3 CHLORIDE ION × 3 water × 12 Consistent with protein count
4 Protein homooligomer Homooligomer Protein 4 ZINC ION × 2 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 1 CHLORIDE ION × 1 water × 4 Consistent with protein count
5 Protein homooligomer Homooligomer Protein 4 ZINC ION × 2 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 1 CHLORIDE ION × 1 water × 4 Consistent with protein count
6 Protein homooligomer Homooligomer Protein 9 ZINC ION × 3 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 3 water × 9 Consistent with protein count
7 Protein homooligomer Homooligomer Protein 6 ZINC ION × 3 N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL) × 3 CHLORIDE ION × 3 water × 6 Consistent with protein count
8 Protein homooligomer Homooligomer Protein 6 ZINC ION × 3 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1efe 1sju 1t0c 2jzq 2kqp 2lwz 4efx 4efx 4efx 4efx 5wbt 8pi6

16 assemblies; showing the first 12

Homodimer
1a7f 1ben 1ben 1guj 1guj 1hiq 1his 1hit 1hls 1hui 1iog 1ioh

155 assemblies; showing the first 12

Homotetramer
1b9e 1b9e 1fub 1lph 1lph 1trz 1trz 1tyl 1tyl 1tym 1tym 1xda

69 assemblies; showing the first 12

Other homooligomers
1ai0 1aiy 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben 1ben

244 assemblies; showing the first 12

Heteromeric or nucleic-acid complex
2g54 2g54 2g56 2g56 2wby 2wby 2wc0 2wc0 3utq 3uts 3uts 3utt

100 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name INS_HUMAN
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 1–21； UniProt 90–110 Author chain C； PDBConstruct 1–21； UniProt 90–110 Author chain B； PDBConstruct 1–30； UniProt 25–54 Author chain D； PDBConstruct 1–30； UniProt 25–54

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1tyl
Deposition date deposition_date1994-06-21
Structure title titleTHE STRUCTURE OF A COMPLEX OF HEXAMERIC INSULIN AND 4'-HYDROXYACETANILIDE
Keywords keywordsHORMONE; HORMONE
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1tyl__assembly_3__model_1

Assembly 3 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1tyl__assembly_3__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1tyl__assembly_3__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）19.52 Å
Rg (electron density)18.37 Å
Total Rg19.16 Å
Atom count2373
Residues300
Excluded volume42082 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1tyl__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1tyl__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1tyl__assembly_3__model_1 dodecameric （12） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1tyl__assembly_4__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 1tyl__assembly_5__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 1tyl__assembly_6__model_1 nonameric （9） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 1tyl__assembly_7__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
8 1 1tyl__assembly_8__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 2 domains

SCOP 2.08 (2 domains)

Domain ID domain_idd1tyl.1
Class classg — Small proteins
Fold Fold foldg.1 — Insulin-like
Superfamily Superfamily superfamilyg.1.1 — Insulin-like
Family Family familyg.1.1.1 — Insulin-like
Domain ID domain_idd1tyl.2
Class classg — Small proteins
Fold Fold foldg.1 — Insulin-like
Superfamily Superfamily superfamilyg.1.1 — Insulin-like
Family Family familyg.1.1.1 — Insulin-like
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7. Citations (3)