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2a1t

Structure of the human MCAD:ETF E165betaA complex

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor

Homo sapiens

UniProt P11310

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Electron transfer flavoprotein alpha-subunit, mitochondrial precursor × 1 （P13804） Electron transfer flavoprotein beta-subunit × 1 （P38117） FLAVIN-ADENINE DINUCLEOTIDE × 5 ADENOSINE MONOPHOSPHATE × 1 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer
1egc 1egd 1ege 4p13 8sgp

5 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1t9g 2a1t

2 assemblies

View Construct and Data Evidence
UniProt name ACADM_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–421； UniProt 1–421 Author chain B； PDBConstruct 1–421； UniProt 1–421 Author chain C； PDBConstruct 1–421； UniProt 1–421 Author chain D； PDBConstruct 1–421； UniProt 1–421

Electron transfer flavoprotein alpha-subunit, mitochondrial precursor

Homo sapiens

UniProt P13804

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor × 4 （P11310） Electron transfer flavoprotein beta-subunit × 1 （P38117） FLAVIN-ADENINE DINUCLEOTIDE × 5 ADENOSINE MONOPHOSPHATE × 1 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1efv 1t9g 2a1t 2a1u

4 assemblies

View Construct and Data Evidence
UniProt name ETFA_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain R； PDBConstruct 1–333； UniProt 1–333

Electron transfer flavoprotein beta-subunit

Homo sapiens

UniProt P38117

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 6 Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor × 4 （P11310） Electron transfer flavoprotein alpha-subunit, mitochondrial precursor × 1 （P13804） FLAVIN-ADENINE DINUCLEOTIDE × 5 ADENOSINE MONOPHOSPHATE × 1 water × 6 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1efv 1t9g 2a1t 2a1u

4 assemblies

View Construct and Data Evidence
UniProt name ETFB_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain S； PDBConstruct 1–255； UniProt 1–255

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id2a1t
Deposition date deposition_date2005-06-21
Structure title titleStructure of the human MCAD:ETF E165betaA complex
Keywords keywords;electron transfer, domain dynamics, conformational sampling, protein:protein complex, fatty acid b-degradation, OXIDOREDUCTASE-ELECTRON TRANSPORT COMPLEX ;; OXIDOREDUCTASE/ELECTRON TRANSPORT
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2a1t__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2a1t__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

2a1t__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）40.18 Å
Rg (electron density)39.90 Å
Total Rg40.20 Å
Atom count16125
Residues2100
Excluded volume286920 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 2a1t__assembly_1__model_1 hexameric （6） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 26 domains

SCOP 2.08 (11 domains)

Domain ID domain_idd2a1ta1
Class classa — All alpha proteins
Fold Fold folda.29 — Bromodomain-like
Superfamily Superfamily superfamilya.29.3 — Acyl-CoA dehydrogenase C-terminal domain-like
Family Family familya.29.3.0 — automated matches
Domain ID domain_idd2a1ta2
Class classe — Multi-domain proteins (alpha and beta)
Fold Fold folde.6 — Acyl-CoA dehydrogenase NM domain-like
Superfamily Superfamily superfamilye.6.1 — Acyl-CoA dehydrogenase NM domain-like
Family Family familye.6.1.1 — Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
Domain ID domain_idd2a1tb1
Class classa — All alpha proteins
Fold Fold folda.29 — Bromodomain-like
Superfamily Superfamily superfamilya.29.3 — Acyl-CoA dehydrogenase C-terminal domain-like
Family Family familya.29.3.0 — automated matches
Domain ID domain_idd2a1tb2
Class classe — Multi-domain proteins (alpha and beta)
Fold Fold folde.6 — Acyl-CoA dehydrogenase NM domain-like
Superfamily Superfamily superfamilye.6.1 — Acyl-CoA dehydrogenase NM domain-like
Family Family familye.6.1.1 — Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
Domain ID domain_idd2a1tc1
Class classa — All alpha proteins
Fold Fold folda.29 — Bromodomain-like
Superfamily Superfamily superfamilya.29.3 — Acyl-CoA dehydrogenase C-terminal domain-like
Family Family familya.29.3.0 — automated matches
Domain ID domain_idd2a1tc2
Class classe — Multi-domain proteins (alpha and beta)
Fold Fold folde.6 — Acyl-CoA dehydrogenase NM domain-like
Superfamily Superfamily superfamilye.6.1 — Acyl-CoA dehydrogenase NM domain-like
Family Family familye.6.1.1 — Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
Domain ID domain_idd2a1td1
Class classa — All alpha proteins
Fold Fold folda.29 — Bromodomain-like
Superfamily Superfamily superfamilya.29.3 — Acyl-CoA dehydrogenase C-terminal domain-like
Family Family familya.29.3.0 — automated matches
Domain ID domain_idd2a1td2
Class classe — Multi-domain proteins (alpha and beta)
Fold Fold folde.6 — Acyl-CoA dehydrogenase NM domain-like
Superfamily Superfamily superfamilye.6.1 — Acyl-CoA dehydrogenase NM domain-like
Family Family familye.6.1.1 — Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
Domain ID domain_idd2a1tr1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.26 — Adenine nucleotide alpha hydrolase-like
Superfamily Superfamily superfamilyc.26.2 — Adenine nucleotide alpha hydrolases-like
Family Family familyc.26.2.3 — ETFP subunits
Domain ID domain_idd2a1tr2
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.31 — DHS-like NAD/FAD-binding domain
Superfamily Superfamily superfamilyc.31.1 — DHS-like NAD/FAD-binding domain
Family Family familyc.31.1.0 — automated matches
Domain ID domain_idd2a1ts1
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.26 — Adenine nucleotide alpha hydrolase-like
Superfamily Superfamily superfamilyc.26.2 — Adenine nucleotide alpha hydrolases-like
Family Family familyc.26.2.3 — ETFP subunits

CATH v4.4 (15 domains)

Domain ID domain_id2a1tA01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology540 — Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homologous superfamily homologous superfamily10 — Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Domain ID domain_id2a1tA02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology110 — Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 2
Domain ID domain_id2a1tA03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology140 — Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 3
Domain ID domain_id2a1tB01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology540 — Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homologous superfamily homologous superfamily10 — Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Domain ID domain_id2a1tB02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology110 — Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 2
Domain ID domain_id2a1tB03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology140 — Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 3
Domain ID domain_id2a1tC01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology540 — Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homologous superfamily homologous superfamily10 — Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Domain ID domain_id2a1tC02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology110 — Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 2
Domain ID domain_id2a1tC03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology140 — Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 3
Domain ID domain_id2a1tD01
Class class1 — Mainly Alpha
Architecture architecture10 — Orthogonal Bundle
Topology topology540 — Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homologous superfamily homologous superfamily10 — Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Domain ID domain_id2a1tD02
Class class2 — Mainly Beta
Architecture architecture40 — Beta Barrel
Topology topology110 — Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 2
Domain ID domain_id2a1tD03
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology140 — Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homologous superfamily homologous superfamily10 — Butyryl-CoA Dehydrogenase, subunit A, domain 3
Domain ID domain_id2a1tR01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily620 — HUPs
Domain ID domain_id2a1tR02
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily1220 — TPP-binding domain
Domain ID domain_id2a1tS01
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily620 — HUPs
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7. Citations (1)