Homo sapiens
| Assembly | Physical composition | Protein state | Molecular copy count | Associated components | Data consistency |
|---|---|---|---|---|---|
| 1 | Protein monomer | Monomer | Protein 1 | COPPER (I) ION × 1 water × 1 | Consistent with protein count |
| UniProt name | A4_HUMAN |
| Isoform | — |
| PDB entities | 1 |
| Chains and sequence ranges | Author chain A； PDBConstruct 3–59； UniProt 133–189 |
The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.
| Entry ID entry_id | 2fk2 |
| Deposition date deposition_date | 2006-01-03 |
| Structure title title | Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound |
| Keywords keywords | Alpha-Beta Two-layered Sandwich, Cu(I) coordination, APOPTOSIS; APOPTOSIS |
| Experimental Method method | X-RAY DIFFRACTION |
This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.
Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)
| Rg（Guinier） | 12.67 Å |
| Rg (electron density) | 11.67 Å |
| Total Rg | 13.04 Å |
| Atom count | 476 |
| Residues | 59 |
| Excluded volume | 8436 ų |
| Maximum q | 0.500 Å⁻¹ |
| Domain ID domain_id | d2fk2a1 |
| Class class | d — Alpha and beta proteins (a+b) |
| Fold Fold fold | d.230 — Dodecin subunit-like |
| Superfamily Superfamily superfamily | d.230.3 — Amyloid beta a4 protein copper binding domain (domain 2) |
| Family Family family | d.230.3.1 — Amyloid beta a4 protein copper binding domain (domain 2) |
| Domain ID domain_id | d2fk2a2 |
| Class class | l — Artifacts |
| Fold Fold fold | l.1 — Tags |
| Superfamily Superfamily superfamily | l.1.1 — Tags |
| Family Family family | l.1.1.1 — Tags |
| Domain ID domain_id | 2fk2A00 |
| Class class | 3 — Alpha Beta |
| Architecture architecture | 30 — 2-Layer Sandwich |
| Topology topology | 1490 — Dna Ligase; domain 1 |
| Homologous superfamily homologous superfamily | 140 — Amyloidogenic glycoprotein, copper-binding domain |