2iub

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DIVALENT CATION TRANSPORT-RELATED PROTEIN

THERMOTOGA MARITIMA

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 5	CHLORIDE ION × 4 MAGNESIUM ION × 11 water × 4	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 5	CHLORIDE ION × 3 MAGNESIUM ION × 10 water × 4	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	Q9WZ31_THEMA
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 13–363； UniProt 1–351 Author chain B； PDBConstruct 13–363； UniProt 1–351 Author chain C； PDBConstruct 13–363； UniProt 1–351 Author chain D； PDBConstruct 13–363； UniProt 1–351 Author chain E； PDBConstruct 13–363； UniProt 1–351 Author chain F； PDBConstruct 13–363； UniProt 1–351 Author chain G； PDBConstruct 13–363； UniProt 1–351 Author chain H； PDBConstruct 13–363； UniProt 1–351 Author chain I； PDBConstruct 13–363； UniProt 1–351 Author chain J； PDBConstruct 13–363； UniProt 1–351

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	2iub
Deposition date deposition_date	2006-06-01
Structure title title	Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.
Keywords keywords	MEMBRANE PROTEIN, CORA, DIVALENT CATION, ION TRANSPORTER; MEMBRANE PROTEIN
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

2iub__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

2iub__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

2iub__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	39.50 Å
Rg (electron density)	39.33 Å
Total Rg	39.77 Å
Atom count	13665
Residues	1655
Excluded volume	247620 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`2iub__assembly_1__model_1`	pentameric （5）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`2iub__assembly_2__model_1`	pentameric （5）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Description description	DIVALENT CATION TRANSPORT-RELATED PROTEIN
Molecular weight formula_weight	42959.7 kDa
Source method src_method	man
Copy count entity_count	10

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J
Atom count atom_count	27580

MGSDKIHHHHHHMEEKRLSAKKGLPPGTLVYTGKYREDFEIEVMNYSIEEFREFKTTDVESVLPFRDSSTPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL

Source Source

Source organism organism	THERMOTOGA MARITIMA
NCBI taxonomy ID ncbi_taxonomy_id	2336
Host organism host_organism	ESCHERICHIA COLI

Entity 2 Entity 2 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	7

Entity 3 Entity 3 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	21

Entity 4 Entity 4 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	13

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6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

Domain ID domain_id	d2iuba1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iuba2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubb1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubb2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubc1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubc2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubd1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubd2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iube1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iube2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubf1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubf2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubg1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubg2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubh1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubh2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubi1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubi2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d2iubj1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d2iubj2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

CATH v4.4 (30 domains)

Domain ID domain_id	2iubA01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubA02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubA03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubB01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubB02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubB03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubC01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubC02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubC03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubD02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubD03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubE01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubE02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubE03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubF01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubF02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubF03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubG01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubG02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubG03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubH01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubH02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubH03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubI01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubI02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubI03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubJ01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	2iubJ02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	2iubJ03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

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Unit-cell length a length_a	116.230 Å
Unit-cell length b length_b	151.460 Å
Unit-cell length c length_c	143.320 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	98.88 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	20

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.900 Å
Low-resolution limit resolution_low	30.000 Å
R factor r_factor	0.2620
R_work r_work	0.2600
R_free r_free	0.2910

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

1. Protein Identity and Related Structures Protein Identity & Related Structures

DIVALENT CATION TRANSPORT-RELATED PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2iub__assembly_1__model_1

2iub__assembly_1__model_1 | I(q)

2iub__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. Citations (1)

Crystal structure of a divalent metal ion transporter CorA at 2.9 A resolution.

1. Protein Identity and Related Structures Protein Identity & Related Structures

DIVALENT CATION TRANSPORT-RELATED PROTEIN

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

2iub__assembly_1__model_1

2iub__assembly_1__model_1 | I(q)

2iub__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (4)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 water

6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. Citations (1)