4i0u

Improved structure of Thermotoga maritima CorA at 2.7 A resolution

Method: X-RAY DIFFRACTION

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Magnesium transport protein CorA

Thermotoga maritima

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein homooligomer	Homooligomer	Protein 5	MAGNESIUM ION × 11 CHLORIDE ION × 8 DODECYL-BETA-D-MALTOSIDE × 3 DI(HYDROXYETHYL)ETHER × 11 2-(2-METHOXYETHOXY)ETHANOL × 1 water × 5	Consistent with protein count
2	Protein homooligomer	Homooligomer	Protein 5	MAGNESIUM ION × 13 CHLORIDE ION × 5 DI(HYDROXYETHYL)ETHER × 10 water × 5	Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CORA_THEMA
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain A； PDBConstruct 1–351； UniProt 1–351 Author chain B； PDBConstruct 1–351； UniProt 1–351 Author chain C； PDBConstruct 1–351； UniProt 1–351 Author chain D； PDBConstruct 1–351； UniProt 1–351 Author chain E； PDBConstruct 1–351； UniProt 1–351 Author chain F； PDBConstruct 1–351； UniProt 1–351 Author chain G； PDBConstruct 1–351； UniProt 1–351 Author chain H； PDBConstruct 1–351； UniProt 1–351 Author chain I； PDBConstruct 1–351； UniProt 1–351 Author chain J； PDBConstruct 1–351； UniProt 1–351

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	4i0u
Deposition date deposition_date	2012-11-19
Structure title title	Improved structure of Thermotoga maritima CorA at 2.7 A resolution
Keywords keywords	magnesium/cobalt transport, METAL TRANSPORT, MEMBRANE PROTEIN, CORA; METAL TRANSPORT
Experimental Method method	X-RAY DIFFRACTION

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

4i0u__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

4i0u__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

4i0u__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	41.68 Å
Rg (electron density)	41.74 Å
Total Rg	42.05 Å
Atom count	14537
Residues	1730
Excluded volume	263710 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`4i0u__assembly_1__model_1`	pentameric （5）	Success	4.1.3-1-20251215 (887e7ef)	View Download
2	1	`4i0u__assembly_2__model_1`	pentameric （5）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Description description	Magnesium transport protein CorA
Molecular weight formula_weight	41498.1 kDa
Source method src_method	man
Copy count entity_count	10

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,B,C,D,E,F,G,H,I,J
Atom count atom_count	29094

MEEKRLSAKKGLPPGTLVYTGKYREDFEIEVMNYSIEEFREFKTTDVESVLPFRDSSTPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVETFRDIVSGLLDVYLSSVSNKTNEVMKVLTIIATIFMPLTFIAGIYGMNFEYMPELRWKWGYPVVLAVMGVIAVIMVVYFKKKKWL

Source Source

Source organism organism	Thermotoga maritima
NCBI taxonomy ID ncbi_taxonomy_id	243274
Host organism host_organism	Escherichia coli

Entity 2 Entity 2 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	24

Entity 3 Entity 3 non-polymer

Description description	CHLORIDE ION
Molecular weight formula_weight	35.5 kDa
Source method src_method	syn
Copy count entity_count	13

Entity 4 Entity 4 non-polymer

Description description	DODECYL-BETA-D-MALTOSIDE
Molecular weight formula_weight	510.6 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 5 Entity 5 non-polymer

Description description	DI(HYDROXYETHYL)ETHER
Molecular weight formula_weight	106.1 kDa
Source method src_method	syn
Copy count entity_count	21

Entity 6 Entity 6 non-polymer

Description description	2-(2-METHOXYETHOXY)ETHANOL
Molecular weight formula_weight	120.1 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 7 Entity 7 water

Description description	water
Molecular weight formula_weight	18.0 kDa
Source method src_method	nat
Copy count entity_count	241

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6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

Domain ID domain_id	d4i0ua1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ua2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0ub1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ub2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0uc1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0uc2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0ud1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ud2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0ue1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ue2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0uf1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0uf2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0ug1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ug2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0uh1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0uh2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0ui1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0ui2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	d4i0uj1
Class class	d — Alpha and beta proteins (a+b)
Fold Fold fold	d.328 — CorA soluble domain-like
Superfamily Superfamily superfamily	d.328.1 — CorA soluble domain-like
Family Family family	d.328.1.1 — CorA soluble domain-like

Domain ID domain_id	d4i0uj2
Class class	f — Membrane and cell surface proteins and peptides
Fold Fold fold	f.17 — Transmembrane helix hairpin
Superfamily Superfamily superfamily	f.17.3 — Magnesium transport protein CorA, transmembrane region
Family Family family	f.17.3.1 — Magnesium transport protein CorA, transmembrane region

CATH v4.4 (30 domains)

Domain ID domain_id	4i0uA01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uA02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uA03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uB01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uB02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uB03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uC01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uC02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uC03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uD01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uD02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uD03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uE01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uE02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uE03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uF01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uF02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uF03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uG01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uG02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uG03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uH01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uH02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uH03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uI01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uI02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uI03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uJ01
Class class	3 — Alpha Beta
Architecture architecture	30 — 2-Layer Sandwich
Topology topology	460 — Beta Polymerase; domain 2
Homologous superfamily homologous superfamily	20 — CorA soluble domain-like

Domain ID domain_id	4i0uJ02
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

Domain ID domain_id	4i0uJ03
Class class	1 — Mainly Alpha
Architecture architecture	20 — Up-down Bundle
Topology topology	58 — Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous superfamily homologous superfamily	340 — Magnesium transport protein CorA, transmembrane region

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Unit-cell length a length_a	116.250 Å
Unit-cell length b length_b	151.500 Å
Unit-cell length c length_c	143.360 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	98.88 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	20

Space group space_group	P 1 21 1
Space-group number int_tables_number	4
Crystal system crystal_system	—

Resolution resolution	2.700 Å
Low-resolution limit resolution_low	38.305 Å
R factor r_factor	0.2312
R_work r_work	0.2281
R_free r_free	0.2891

Improved structure of Thermotoga maritima CorA at 2.7 A resolution

1. Protein Identity and Related Structures Protein Identity & Related Structures

Magnesium transport protein CorA

State in the Current Structure

Other States of the Same Protein in the Database

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4i0u__assembly_1__model_1

4i0u__assembly_1__model_1 | I(q)

4i0u__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 non-polymer

Entity 6 Entity 6 non-polymer

Entity 7 Entity 7 water

6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. Citations (1)

Improved structure of Thermotoga maritima CorA at 2.7 A resolution

1. Protein Identity and Related Structures Protein Identity & Related Structures

Magnesium transport protein CorA

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

2. Structure Basics 2. Structure Basics

3. Official assembly/model SAXS Official SAXS Profiles

4i0u__assembly_1__model_1

4i0u__assembly_1__model_1 | I(q)

4i0u__assembly_1__model_1 | P(r) · Pending

4. Crystallography and Experiment 4. Crystallography & Experiment

Unit cell Unit Cell

Symmetry Symmetry

Refinement Refinement

Diffraction experiment Diffraction

5. Entities and Polymers Entities & Polymers (7)

Entity 1 Entity 1 polymer

Polymer Polymer

Source Source

Entity 2 Entity 2 non-polymer

Entity 3 Entity 3 non-polymer

Entity 4 Entity 4 non-polymer

Entity 5 Entity 5 non-polymer

Entity 6 Entity 6 non-polymer

Entity 7 Entity 7 water

6. Fold Classification (SCOP + CATH) 50 domains

SCOP 2.08 (20 domains)

CATH v4.4 (30 domains)

7. Citations (1)