2j1w
Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
SAXS 散射曲线 SAXS Profile
P(r) 距离分布 P(r) Distribution
1. 结构基本信息 1. Structure Basics
| 条目编号 entry_id | 2j1w |
| 沉积日期 deposition_date | 2006-08-15 |
| 结构标题 title | Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D |
| 关键词 keywords | ;SECOND-SITE SUPPRESSOR MUTATION, DISEASE MUTATION, NUCLEAR PROTEIN, PHOSPHORYLATION, TUMOR SUPPRESSOR, ALTERNATIVE SPLICING, LI-FRAUMENI SYNDROME, LI- FRAUMENI SYNDROME, HOST-VIRUS INTERACTION, TRANSCRIPTION, METAL-BINDING, ANTI-ONCOGENE, DNA-BINDING, TRANSFERASE, POLYMORPHISM, GLYCOPROTEIN, ZINC, ACTIVATOR, APOPTOSIS, CELL CYCLE, ACETYLATION, P53 DNA-BINDING DOMAIN, TRANSCRIPTION REGULATION, SUPERSTABLE MUTANT, DNA-BINDING PROTEIN ;; NUCLEAR PROTEIN |
| 实验方法 method | X-RAY DIFFRACTION |
2. SAXS 参数 (CRYSOL 理论计算) 2. SAXS Parameters (CRYSOL)
| 回转半径 Rg (Guinier) rg_guinier | 24.40 Å |
| 回转半径 Rg (电子) rg_electron | 23.43 Å |
| 零角强度 I(0) i0 | 36921500.00 |
| 分子量 molecular_weight | 44027.0 kDa |
| 排除体积 excluded_volume | 53888 ų |
| 包络体积 envelope_volume | 67488 ų |
| 水化壳体积 shell_volume | 24103 ų |
| 包络直径 envelope_diameter | 76.6 Å |
| 壳层 Rg shell_rg | 30.25 Å |
| 包络 Rg envelope_rg | 23.24 Å |
| 形状 Rg shape_rg | 23.43 Å |
| 总 Rg total_rg | 24.21 Å |
| 总原子数 total_atoms | 3070 |
| 残基数 n_residues | 390 |
| 球谐函数阶数 n_harmonics | 20 |
| q 范围 q_range | — – 0.5000 Å−1 |
| 数据点数 n_points | 101 |
| 壳层类型 shell_type | directional |
| 溶剂电子密度 solvent_density | 0.3340 e/ų |
| 壳层衬度 contrast_shell | 0.0300 e/ų |
| CRYSOL 版本 crysol_version | 4.1.3 |
3. P(r) 距离分布 (GNOM 反演) 3. P(r) Analysis (GNOM)
| 最大尺寸 Dmax dmax | 73.8 Å |
| Rg (实空间) rg_real | 24.31 Å |
| Rg 误差 (实空间) rg_real_error | 0.37 Å |
| I(0) (实空间) i0_real | 3.6920e+07 |
| I(0) 误差 (实空间) i0_real_error | 4.9640e+05 |
| Rg (倒空间) rg_reciprocal | 24.33 Å |
| I(0) (倒空间) i0_reciprocal | 36920000.0000 |
| 解质量估计 total_estimate | 0.7161 |
| 解质量评级 solution_quality | REASONABLE a REASONABLE solution |
| P(r) 峰数 n_peaks | 2 |
| 主峰位置 r_peak_primary | 29.3 Å |
| 偏度 Skewness skewness | 0.187 |
| 峰度 Kurtosis kurtosis | -0.586 |
| 角度范围 angular_range | — – 0.3250 Å−1 |
| 当前正则化参数 α current_alpha | 0.0000 |
| 最高正则化参数 α highest_alpha | 3872000.0000 |
| 实空间数据点数 n_real_points | 64 |
| GNOM 版本 gnom_version | 4.1.3 |
| 质量判据 quality_criteria | AN1: 0.000; Oscil: 0.978; Stabil: 1.000; Sysdev: 0.137; Positv: 1.000; Valcen: 1.000; Smooth: 0.959 |
4. 晶体学与实验 4. Crystallography & Experiment
5. 实体与聚合体信息 (3)
6. 折叠分类 (SCOP + CATH) 4 domains
SCOP 2.08 (2 domains)
| 结构域编号 domain_id | d2j1wa_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.2 — Common fold of diphtheria toxin/transcription factors/cytochrome f |
| 超家族 Superfamily superfamily | b.2.5 — p53-like transcription factors |
| 家族 Family family | b.2.5.2 — p53 DNA-binding domain-like |
| 结构域编号 domain_id | d2j1wb_ |
| 类 Class class | b — All beta proteins |
| 折叠类型 Fold fold | b.2 — Common fold of diphtheria toxin/transcription factors/cytochrome f |
| 超家族 Superfamily superfamily | b.2.5 — p53-like transcription factors |
| 家族 Family family | b.2.5.2 — p53 DNA-binding domain-like |
CATH v4.4 (2 domains)
| 结构域编号 domain_id | 2j1wA00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 720 — |
| 结构域编号 domain_id | 2j1wB00 |
| 类 Class class | 2 — Mainly Beta |
| 架构 Architecture architecture | 60 — Sandwich |
| 拓扑 Topology topology | 40 — Immunoglobulin-like |
| 同源超家族 H-superfamily homologous superfamily | 720 — |